Entity Details

Primary name MMP11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP24347
EntryNameMMP11_HUMAN
FullNameStromelysin-3
TaxID9606
Evidenceevidence at protein level
Length488
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GenesMMP11

GO terms

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GOName
GO:0004222 metalloendopeptidase activity
GO:0005576 extracellular region
GO:0005796 Golgi lumen
GO:0006508 proteolysis
GO:0007275 multicellular organism development
GO:0008270 zinc ion binding
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030574 collagen catabolic process
GO:0031012 extracellular matrix
GO:0045599 negative regulation of fat cell differentiation
GO:0071711 basement membrane organization

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000585 Hemopexin-like domainDomainDomain
IPR001818 Peptidase M10, metallopeptidaseDomainDomain
IPR006026 Peptidase, metallopeptidaseDomainDomain
IPR018486 Hemopexin, conserved siteSiteConserved site
IPR018487 Hemopexin-like repeatsRepeatRepeat
IPR021158 Peptidase M10A, cysteine switch, zinc binding siteSiteBinding site
IPR021190 Peptidase M10AFamilyFamily
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR028705 Stromelysin-3FamilyFamily
IPR033739 Peptidase M10A, catalytic domainDomainDomain
IPR036375 Hemopexin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00786 MarimastatDrugbanksmall molecule
DB04318 Na-[(2S)-2-{[(S)-[(1S)-1-{[(Benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl]methyl}-5-phenylpentanoyl]-L-tryptophanamideDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MMP11_HUMANPR40A_HUMANHPRD15231748 details
MMP11_HUMANA1AT_HUMANHPRD7523394 details