Entity Details

Primary name AKAP5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP24588
EntryNameAKAP5_HUMAN
FullNameA-kinase anchor protein 5
TaxID9606
Evidenceevidence at protein level
Length427
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GenesAKAP5

GO terms

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GOName
GO:0005516 calmodulin binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007268 chemical synaptic transmission
GO:0008179 adenylate cyclase binding
GO:0009898 cytoplasmic side of plasma membrane
GO:0010738 regulation of protein kinase A signaling
GO:0014069 postsynaptic density
GO:0017124 SH3 domain binding
GO:0030346 protein phosphatase 2B binding
GO:0031698 beta-2 adrenergic receptor binding
GO:0032590 dendrite membrane
GO:0034237 protein kinase A regulatory subunit binding
GO:0035254 glutamate receptor binding
GO:0043197 dendritic spine
GO:0045121 membrane raft
GO:0045762 positive regulation of adenylate cyclase activity
GO:0050811 GABA receptor binding
GO:0051018 protein kinase A binding
GO:0060076 excitatory synapse
GO:0060090 molecular adaptor activity
GO:0097110 scaffold protein binding
GO:0098837 postsynaptic recycling endosome
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1905751 positive regulation of endosome to plasma membrane protein transport

Subcellular Location

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Subcellular Location
Postsynaptic recycling endosome membrane

Domains

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DomainNameCategoryType
IPR001573 A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motifDomainDomain
IPR042375 A-kinase anchor protein 5FamilyFamily

Diseases

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Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
AKAP5_HUMANKAP2_HUMANBioGRID, DIP, HPRD, IntAct, MINT11557526 12672969 16642035 22343722 26496610 31182485 details
AKAP5_HUMANKAP0_HUMANBioGRID, IntAct32296183 details
AKAP5_HUMANROP1A_HUMANBioGRID, IntAct32296183 details
AKAP5_HUMANKAP3_HUMANBioGRID, HPRD, IntAct11557526 26186194 28514442 32296183 8509414 details
AKAP5_HUMANPP2BA_HUMANBioGRID, DIP, HPRD, IntAct22343722 32296183 7528941 9765270 details
AKAP5_HUMANROP1L_HUMANBioGRID, IntAct32296183 details
AKAP5_HUMANIQGA1_HUMANBioGRID, HPRD12938160 details
AKAP5_HUMANGBRB3_HUMANBioGRID, HPRD12595241 details
AKAP5_HUMANCALM1_HUMANBioGRID, HPRD9202019 details
AKAP5_HUMANCALM2_HUMANBioGRID, HPRD9202019 details
AKAP5_HUMANCALM3_HUMANBioGRID, HPRD9202019 details
AKAP5_HUMANTRPV1_HUMANBioGRID18701070 details
AKAP5_HUMANJUN_HUMANBioGRID31182485 details
AKAP5_HUMANP53_HUMANBioGRID31182485 details
AKAP5_HUMANFOS_HUMANBioGRID31182485 details
AKAP5_HUMANMDM2_HUMANBioGRID31182485 details
AKAP5_HUMANKCNJ2_HUMANHPRD, IntAct11287423 details
AKAP5_HUMANRXFP1_HUMANMINT20664520 details
AKAP5_HUMANKPCA_HUMANBioGRID, HPRD11557526 9202019 details
AKAP5_HUMANTRPV4_HUMANBioGRID18701070 details
AKAP5_HUMANTRPM8_HUMANBioGRID18701070 details
AKAP5_HUMANTRPA1_HUMANBioGRID18701070 details
AKAP5_HUMANTRPV2_HUMANBioGRID18701070 details
AKAP5_HUMANTRPV3_HUMANBioGRID18701070 details
AKAP5_HUMANADRB2_HUMANHPRD10753752 details
AKAP5_HUMANDLG1_HUMANHPRD10939335 details
AKAP5_HUMANDLG4_HUMANHPRD10939335 details
AKAP5_HUMANGBRB1_HUMANHPRD12595241 details
AKAP5_HUMANRET_HUMANHPRD11886862 details