Entity Details

Primary name HRH2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25021
EntryNameHRH2_HUMAN
FullNameHistamine H2 receptor
TaxID9606
Evidenceevidence at transcript level
Length359
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesHRH2

GO terms

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GOName
GO:0001696 gastric acid secretion
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004969 histamine receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007268 chemical synaptic transmission
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0045202 synapse
GO:0045907 positive regulation of vasoconstriction

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000503 Histamine H2 receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00272 BetazoleDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00501 CimetidineDrugbanksmall molecule
DB00585 NizatidineDrugbanksmall molecule
DB00751 EpinastineDrugbanksmall molecule
DB00768 OlopatadineDrugbanksmall molecule
DB00797 TolazolineDrugbanksmall molecule
DB00863 RanitidineDrugbanksmall molecule
DB00927 FamotidineDrugbanksmall molecule
DB00940 MethanthelineDrugbanksmall molecule
DB00972 AzelastineDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB05369 HZT-501Drugbanksmall molecule
DB05381 HistamineDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB08805 MetiamideDrugbanksmall molecule
DB08806 Roxatidine acetateDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
HRH2_HUMANGASP2_HUMANHPRD15086532 details