Entity Details

Primary name UCP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25874
EntryNameUCP1_HUMAN
FullNameMitochondrial brown fat uncoupling protein 1
TaxID9606
Evidenceevidence at protein level
Length307
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesUCP1

GO terms

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GOName
GO:0002024 diet induced thermogenesis
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0009266 response to temperature stimulus
GO:0009409 response to cold
GO:0016021 integral component of membrane
GO:0017077 oxidative phosphorylation uncoupler activity
GO:0022857 transmembrane transporter activity
GO:0031667 response to nutrient levels
GO:0032555 purine ribonucleotide binding
GO:0032870 cellular response to hormone stimulus
GO:0034614 cellular response to reactive oxygen species
GO:0036041 long-chain fatty acid binding
GO:0050873 brown fat cell differentiation
GO:0070417 cellular response to cold
GO:0071398 cellular response to fatty acid
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1901612 cardiolipin binding
GO:1902600 proton transmembrane transport
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1990542 mitochondrial transmembrane transport
GO:1990845 adaptive thermogenesis

Subcellular Location

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Subcellular Location
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR002030 Mitochondrial carrier UCP-likeFamilyFamily
IPR018108 Mitochondrial substrate/solute carrierRepeatRepeat
IPR023395 Mitochondrial carrier domain superfamilyFamilyHomologous superfamily
IPR040011 Mitochondrial brown fat uncoupling protein 1FamilyFamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
UCP1_HUMANTOM20_HUMANBioGRID, HPRD9119086 details
UCP1_HUMANNDK8_HUMANIntAct28514442 details