Entity Details

Primary name PSB6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28072
EntryNamePSB6_HUMAN
FullNameProteasome subunit beta type-6
TaxID9606
Evidenceevidence at protein level
Length239
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesPSMB6

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0006521 regulation of cellular amino acid metabolic process
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016032 viral process
GO:0016579 protein deubiquitination
GO:0019774 proteasome core complex, beta-subunit complex
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0036388 pre-replicative complex assembly
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0045296 cadherin binding
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000243 Peptidase T1A, proteasome beta-subunitFamilyFamily
IPR001353 Proteasome, subunit alpha/betaFamilyFamily
IPR016050 Proteasome beta-type subunit, conserved siteSiteConserved site
IPR023333 Proteasome B-type subunitFamilyFamily
IPR029055 Nucleophile aminohydrolases, N-terminalFamilyHomologous superfamily
IPR035140 Proteasome subunit beta 6FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB08515 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDEDrugbanksmall molecule

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
PSB6_HUMANPSB7_HUMANBioGRID, HPRD, IntAct, MINT11745344 14733938 17948026 22863883 22939629 26186194 26344197 28514442 details
PSB6_HUMANPOMP_HUMANBioGRID, HPRD, IntAct, MINT14733938 17948026 details
PSB6_HUMANEZH2_HUMANBioGRID, HPRD, IntAct16169070 details
PSB6_HUMANPSA6_HUMANBioGRID, MINT17948026 22863883 22939629 26344197 details
PSB6_HUMANNDOR1_HUMANBioGRID, IntAct32296183 details
PSB6_HUMANPSB3_HUMANBioGRID, IntAct17948026 22863883 22939629 26344197 28514442 details
PSB6_HUMANHD_HUMANIntAct32814053 details
PSB6_HUMANPSB5_HUMANBioGRID11745344 17948026 22863883 22939629 26344197 details
PSB6_HUMANPSMA8_HUMANBioGRID17948026 22939629 26344197 details
PSB6_HUMANPSB8_HUMANBioGRID11745344 17948026 22863883 22939629 26344197 details
PSB6_HUMANERRFI_HUMANBioGRID20351267 details
PSB6_HUMANTRAF6_HUMANIntAct14743216 details
PSB6_HUMANPSA2_HUMANBioGRID, IntAct12376572 15887188 19193609 22863883 22939629 26344197 details
PSB6_HUMANIKKE_HUMANIntAct17353931 details
PSB6_HUMANHLAB_HUMANIntAct17353931 details
PSB6_HUMANMDM2_HUMANBioGRID, MINT22659184 details
PSB6_HUMANPSB2_HUMANBioGRID, IntAct22863883 22939629 26344197 28514442 32723828 details
PSB6_HUMANPLK1_HUMANBioGRID, HPRD11205743 details
PSB6_HUMANRD23A_HUMANBioGRID19013454 details
PSB6_HUMANPSA4_HUMANBioGRID22863883 22939629 26344197 9311996 details
PSB6_HUMANUBP7_HUMANBioGRID19193609 details
PSB6_HUMANPSB9_HUMANBioGRID11745344 details
PSB6_HUMANPSB10_HUMANBioGRID11745344 22939629 details
PSB6_HUMANPSME1_HUMANBioGRID11745344 details
PSB6_HUMANPSME2_HUMANBioGRID11745344 details
PSB6_HUMANPSDE_HUMANBioGRID17323924 22939629 26344197 27428775 28821611 details
PSB6_HUMANTRI18_HUMANBioGRID26748699 details
PSB6_HUMANFBX7_HUMANBioGRID27497298 27503909 details
PSB6_HUMANDERL1_HUMANBioGRID28137758 details
PSB6_HUMANUBE3A_HUMANBioGRID22645313 29426014 30257870 details
PSB6_HUMANFGF11_HUMANBioGRID28027390 details
PSB6_HUMANFBRL_HUMANHPRD12388758 details