Entity Details

Primary name PML_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29590
EntryNamePML_HUMAN
FullNameProtein PML
TaxID9606
Evidenceevidence at protein level
Length882
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesPML

GO terms

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GOName
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000792 heterochromatin
GO:0001666 response to hypoxia
GO:0001932 regulation of protein phosphorylation
GO:0002230 positive regulation of defense response to virus by host
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006605 protein targeting
GO:0006606 protein import into nucleus
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007182 common-partner SMAD protein phosphorylation
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009411 response to UV
GO:0010332 response to gamma radiation
GO:0010522 regulation of calcium ion transport into cytosol
GO:0010761 fibroblast migration
GO:0016363 nuclear matrix
GO:0016525 negative regulation of angiogenesis
GO:0016605 PML body
GO:0019058 viral life cycle
GO:0030155 regulation of cell adhesion
GO:0030308 negative regulation of cell growth
GO:0030578 PML body organization
GO:0030851 granulocyte differentiation
GO:0031065 positive regulation of histone deacetylation
GO:0031625 ubiquitin protein ligase binding
GO:0031901 early endosome membrane
GO:0031965 nuclear membrane
GO:0032183 SUMO binding
GO:0032206 positive regulation of telomere maintenance
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032922 circadian regulation of gene expression
GO:0032938 negative regulation of translation in response to oxidative stress
GO:0034097 response to cytokine
GO:0042406 extrinsic component of endoplasmic reticulum membrane
GO:0042752 regulation of circadian rhythm
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043153 entrainment of circadian clock by photoperiod
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response
GO:0045165 cell fate commitment
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0046332 SMAD binding
GO:0046982 protein heterodimerization activity
GO:0048146 positive regulation of fibroblast proliferation
GO:0048384 retinoic acid receptor signaling pathway
GO:0050821 protein stabilization
GO:0050897 cobalt ion binding
GO:0051457 maintenance of protein location in nucleus
GO:0051607 defense response to virus
GO:0051974 negative regulation of telomerase activity
GO:0060058 positive regulation of apoptotic process involved in mammary gland involution
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0065003 protein-containing complex assembly
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071353 cellular response to interleukin-4
GO:0090398 cellular senescence
GO:0097191 extrinsic apoptotic signaling pathway
GO:0140037 sumo-dependent protein binding
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902187 negative regulation of viral release from host cell
GO:1904816 positive regulation of protein localization to chromosome, telomeric region
GO:1990830 cellular response to leukemia inhibitory factor
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2000779 regulation of double-strand break repair
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Early endosome membrane
Endoplasmic reticulum membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000315 B-box-type zinc fingerDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR021978 Protein of unknown function DUF3583FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01169 Arsenic trioxideDrugbanksmall molecule

Interactions

216 interactions

InteractorPartnerSourcesPublicationsLink
PML_HUMANDAXX_HUMANBioGRID, IntAct10525530 10545115 10669754 10684855 11244500 12150977 12529400 14517282 15710327 17081986 17360386 17419608 20972456 21474068 21482821 21779164 21840486 23222847 24637324 30292834 details
PML_HUMANSUMO1_HUMANBioGRID, DIP, HPRD, I2D, IntAct, MINT11080164 11948183 17036045 17081985 17344210 19217413 19380586 21057547 21779164 22875967 25497731 28851805 8806687 9756909 9885291 details
PML_HUMANZBT16_HUMANBioGRID, HPRD, IntAct11175338 9294197 details
PML_HUMANPML_HUMANBioGRID, HPRD, IntAct10669754 10938104 12438698 12837286 16540467 16778193 20211142 22493164 22773875 27903803 29599493 32296183 9230084 9294197 9671498 details
PML_HUMANMDM2_HUMANBioGRID, HPRD, IntAct12759344 12915590 14507915 15195100 19150978 20972456 22869143 23169665 details
PML_HUMANP53_HUMANBioGRID, HPRD, I2D, IntAct, UniProt11025664 11080164 11704853 12006491 12915590 14976551 15375079 16007146 20972456 21057547 22869143 25241761 details
PML_HUMANCSK21_HUMANBioGRID, HPRD, IntAct16873060 19217413 20625391 22406621 details
PML_HUMANTGIF1_HUMANBioGRID, HPRD, MINT16916642 18511908 details
PML_HUMANUBE2U_HUMANBioGRID, IntAct19690564 details
PML_HUMANIF4E_HUMANBioGRID, HPRD, MINT11500381 11575918 12167712 12438698 19262567 details
PML_HUMANBANP_HUMANBioGRID, MINT20075864 22013068 details
PML_HUMANKLH20_HUMANBioGRID, IntAct, MINT20389280 21840486 24487962 25619834 details
PML_HUMANMK07_HUMANBioGRID, IntAct20832753 22869143 details
PML_HUMANMYB_HUMANBioGRID, HPRD, I2D15194430 20802522 details
PML_HUMANMYC_HUMANBioGRID, HPRD, IntAct15735755 17146439 21150319 30415952 details
PML_HUMANAXIN1_HUMANBioGRID, I2D21057547 details
PML_HUMANADH1B_HUMANBioGRID, IntAct21988832 details
PML_HUMANNFKB1_HUMANBioGRID, IntAct21988832 details
PML_HUMANPLS1_HUMANBioGRID, IntAct21988832 details
PML_HUMANUBC9_HUMANBioGRID, IntAct12641448 15561718 15809060 17081986 18691969 21988832 22155184 27030546 27903803 29535160 29599493 29773808 30292834 30935967 32001251 9885291 details
PML_HUMANPSA3_HUMANBioGRID, IntAct21988832 details
PML_HUMANSH3G1_HUMANBioGRID, IntAct21988832 details
PML_HUMANC8AP2_HUMANBioGRID, IntAct21988832 details
PML_HUMANRN111_HUMANBioGRID, IntAct22493164 23530056 details
PML_HUMANRN125_HUMANBioGRID, IntAct22493164 details
PML_HUMANPIN1_HUMANBioGRID, IntAct18039859 20100838 21840486 22033920 24586174 details
PML_HUMANCDK6_HUMANBioGRID, IntAct21840486 details
PML_HUMANCDK2_HUMANBioGRID, IntAct21840486 details
PML_HUMANCDK1_HUMANBioGRID, IntAct21840486 details
PML_HUMANSIR1_HUMANBioGRID, UniProt12006491 details
PML_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 details
PML_HUMANRPAB1_HUMANBioGRID, IntAct20211142 details
PML_HUMANGCR_HUMANBioGRID, IntAct20211142 details
PML_HUMANPPARG_HUMANBioGRID, IntAct20211142 details
PML_HUMANPHS2_HUMANBioGRID, IntAct20211142 details
PML_HUMANMED7_HUMANBioGRID, IntAct20211142 details
PML_HUMANGATA2_HUMANBioGRID, HPRD10938104 details
PML_HUMANTDG_HUMANBioGRID, HPRD15569683 17060459 details
PML_HUMANCHFR_HUMANBioGRID, HPRD15467728 details
PML_HUMANMK11_HUMANBioGRID15273249 details
PML_HUMANRL11_HUMANBioGRID, HPRD15195100 23169665 details
PML_HUMANANKR2_HUMANBioGRID, HPRD15136035 details
PML_HUMANCCNT1_HUMANBioGRID, HPRD12727882 28555140 details
PML_HUMANSRF_HUMANBioGRID, HPRD12622724 details
PML_HUMANCBP_HUMANBioGRID, HPRD10077561 10610177 12142048 12234245 12622724 25733689 details
PML_HUMANNCOR2_HUMANBioGRID, HPRD11430826 11585900 details
PML_HUMANSIN3A_HUMANBioGRID, HPRD11430826 details
PML_HUMANNCOR1_HUMANBioGRID, HPRD10882117 11430826 details
PML_HUMANHDAC1_HUMANBioGRID, HPRD11259576 11430826 18644863 23563092 25812002 details
PML_HUMANSKI_HUMANBioGRID, HPRD11430826 details
PML_HUMANHDAC3_HUMANBioGRID, HPRD11259576 details
PML_HUMANHDAC2_HUMANBioGRID, HPRD11259576 18073335 18644863 25812002 details
PML_HUMANRARA_HUMANBioGRID, HPRD10610177 10882117 11050004 12935927 1311253 16540467 17560333 18073335 20159610 details
PML_HUMANRXRA_HUMANBioGRID10610177 16540467 details
PML_HUMANRB_HUMANBioGRID, HPRD9448006 details
PML_HUMANHHEX_HUMANBioGRID, HPRD10597310 details
PML_HUMANNR4A1_HUMANBioGRID, HPRD12032831 details
PML_HUMANSTAT3_HUMANBioGRID, HPRD12506013 details
PML_HUMANJUN_HUMANBioGRID10620019 15626733 16916642 9671405 details
PML_HUMANFOS_HUMANBioGRID9671405 details
PML_HUMANATF2_HUMANBioGRID9671405 details
PML_HUMANBCL6_HUMANBioGRID11175338 details
PML_HUMANSP1_HUMANBioGRID, HPRD21360626 24728382 9819401 details
PML_HUMANARNT_HUMANBioGRID, HPRD12354770 details
PML_HUMANTRI27_HUMANBioGRID, HPRD9570750 details
PML_HUMANPLAL1_HUMANBioGRID20097304 details
PML_HUMANKAT5_HUMANBioGRID19150978 details
PML_HUMANSATB1_HUMANBioGRID17173041 18408014 details
PML_HUMANUBE3A_HUMANBioGRID19325566 details
PML_HUMANSP100_HUMANBioGRID11112690 21172801 21779164 24637324 9230084 details
PML_HUMANPIAS2_HUMANBioGRID21779164 22406621 details
PML_HUMANSUMO2_HUMANBioGRID, HPRD21779164 28851805 9452416 details
PML_HUMANMAGA2_HUMANBioGRID22117195 details
PML_HUMANRNF4_HUMANBioGRID15707587 18408734 18708055 19380586 21252943 22388745 23028697 24637324 24907272 29180619 details
PML_HUMANPIAS1_HUMANBioGRID22406621 details
PML_HUMANCTNB1_HUMANBioGRID12384561 22155184 details
PML_HUMANRBX1_HUMANBioGRID18809579 21840486 details
PML_HUMANHIPK2_HUMANBioGRID19015637 20188669 21145359 21192925 details
PML_HUMANCHK2_HUMANBioGRID12402044 details
PML_HUMANSYNE2_HUMANBioGRID19861416 details
PML_HUMANSIAH2_HUMANBioGRID14645235 details
PML_HUMANARI3A_HUMANBioGRID, HPRD15017387 details
PML_HUMANP63_HUMANBioGRID16007146 details
PML_HUMANKAT6A_HUMANBioGRID23431171 details
PML_HUMANATX1_HUMANBioGRID24882209 details
PML_HUMANHD_HUMANBioGRID24882209 details
PML_HUMANNCOA2_HUMANBioGRID23542129 details
PML_HUMANEGFR_HUMANBioGRID23563092 details
PML_HUMANSENP1_HUMANBioGRID21098080 details
PML_HUMANGATA1_HUMANBioGRID24255919 details
PML_HUMANNACC1_HUMANBioGRID25891951 details
PML_HUMANUBP11_HUMANBioGRID24487962 details
PML_HUMANZN451_HUMANBioGRID27343429 details
PML_HUMANTRIB3_HUMANBioGRID28486108 details
PML_HUMANEIF3K_HUMANBioGRID24036361 details
PML_HUMANMD1L1_HUMANBioGRID30948704 details
PML_HUMANERPG3_HUMANBioGRID31722399 details
PML_HUMANERCC6_HUMANBioGRID31722399 details
PML_HUMANPAXI1_HUMANHPRD11940591 details
PML_HUMANSUV91_HUMANHPRD, IntAct16449642 details
PML_HUMANARF_HUMANBioGRID, IntAct12740913 26578773 details
PML_HUMANSUMO3_HUMANBioGRID, HPRD, IntAct15576338 17000644 21779164 details
PML_HUMANTOP3A_HUMANMINT18418389 details
PML_HUMANZFYV9_HUMANBioGRID, HPRD, MINT15356634 16916642 18511908 details
PML_HUMANSSBP2_HUMANMolecular Connections20540776 details
PML_HUMANAIMP2_HUMANMINT21285945 details
PML_HUMANCUL3_HUMANIntAct21840486 details
PML_HUMANTNR6_HUMANBioGRID, IntAct21803845 details
PML_HUMANTBX2_HUMANBioGRID, MINT22002537 details
PML_HUMANNF1_HUMANBioGRID, IntAct22293200 details
PML_HUMANTERT_HUMANbhf-ucl, BioGRID19567472 details
PML_HUMANASC_HUMANBioGRID, HPIDb24407287 details
PML_HUMANUBP7_HUMANBioGRID, IntAct20719947 21305000 26496610 details
PML_HUMANTULP3_HUMANBioGRID, IntAct28514442 33187986 details
PML_HUMANPSME3_HUMANBioGRID, IntAct19556897 26186194 28514442 details
PML_HUMANPSF2_HUMANMINT23589040 details
PML_HUMANTP53B_HUMANBioGRID, UniProt29656893 31009828 details
PML_HUMANNF2L2_HUMANMINT28777872 details
PML_HUMANTET2_HUMANBioGRID, MINT29735542 details
PML_HUMANPER2_HUMANBioGRID, IntAct22274616 details
PML_HUMANFXR1_HUMANMINT21653829 details
PML_HUMANSMAD3_HUMANBioGRID, HPRD15356634 details
PML_HUMANSMAD2_HUMANBioGRID15356634 details
PML_HUMANTRI69_HUMANBioGRID, HPRD12837286 details
PML_HUMANTOPB1_HUMANBioGRID, HPRD12773567 19023333 details
PML_HUMANTIF1A_HUMANBioGRID, HPRD10610177 details
PML_HUMANTF65_HUMANBioGRID, HPRD12540841 25733689 details
PML_HUMANNR2C1_HUMANBioGRID19204783 21360626 details
PML_HUMANCHD4_HUMANBioGRID18644863 details
PML_HUMANZN506_HUMANBioGRID16412420 details
PML_HUMANFOXO1_HUMANBioGRID16154098 details
PML_HUMANHDAC7_HUMANBioGRID18463162 22155184 details
PML_HUMANTOP2B_HUMANBioGRID18212063 details
PML_HUMANSP130_HUMANBioGRID18212063 details
PML_HUMANHNRPU_HUMANBioGRID18212063 details
PML_HUMANRFC4_HUMANBioGRID18212063 details
PML_HUMANNPM_HUMANBioGRID18212063 28740552 details
PML_HUMANMRT4_HUMANBioGRID18212063 details
PML_HUMANSNR40_HUMANBioGRID18212063 details
PML_HUMANRUNX1_HUMANBioGRID15331439 18073335 details
PML_HUMANSIAH1_HUMANBioGRID18073335 details
PML_HUMANSF01_HUMANBioGRID21360626 details
PML_HUMANSMCA4_HUMANBioGRID21360626 details
PML_HUMANSPI1_HUMANBioGRID20159610 details
PML_HUMANSETB1_HUMANBioGRID21921037 details
PML_HUMANH2AX_HUMANBioGRID21704408 31009828 details
PML_HUMANATX3_HUMANBioGRID11572863 details
PML_HUMANMAF_HUMANBioGRID19553542 details
PML_HUMANARI2_HUMANBioGRID22037423 details
PML_HUMANCSK2B_HUMANBioGRID20719947 details
PML_HUMANYAP1_HUMANBioGRID19111660 details
PML_HUMANRBP2_HUMANBioGRID22155184 details
PML_HUMANHOIL1_HUMANBioGRID15833741 details
PML_HUMANMP2K4_HUMANBioGRID10620019 details
PML_HUMANFBX3_HUMANBioGRID18809579 details
PML_HUMANCUL1_HUMANBioGRID18809579 details
PML_HUMANSKP1_HUMANBioGRID18809579 details
PML_HUMANUHRF1_HUMANBioGRID22945642 details
PML_HUMANTOPRS_HUMANBioGRID20188669 details
PML_HUMANIKKE_HUMANBioGRID20188669 details
PML_HUMANZMYM2_HUMANBioGRID17027752 25133527 details
PML_HUMANEAA2_HUMANBioGRID17823119 details
PML_HUMANWRN_HUMANBioGRID21639834 details
PML_HUMANIEX1_HUMANBioGRID15855159 details
PML_HUMANRAD51_HUMANBioGRID21998700 details
PML_HUMANMK03_HUMANBioGRID19861416 details
PML_HUMANMK01_HUMANBioGRID19861416 22033920 details
PML_HUMANRUNX3_HUMANBioGRID15331439 details
PML_HUMANRUNX2_HUMANBioGRID15331439 details
PML_HUMANKPYM_HUMANBioGRID18298799 details
PML_HUMANCSK23_HUMANBioGRID14522971 20625391 details
PML_HUMANPLCG1_HUMANBioGRID17419608 details
PML_HUMANELF4_HUMANBioGRID, HPRD14976184 details
PML_HUMANBCL2_HUMANBioGRID, HPRD15231068 details
PML_HUMANAURKA_HUMANBioGRID, HPRD15749021 details
PML_HUMANNFAC1_HUMANBioGRID18246125 details
PML_HUMANMTOR_HUMANBioGRID16915281 details
PML_HUMANKC1D_HUMANBioGRID18246126 details
PML_HUMANGLIS2_HUMANBioGRID24500717 details
PML_HUMANJAK1_HUMANBioGRID20409569 details
PML_HUMANMCAF1_HUMANBioGRID23935871 details
PML_HUMANEHMT2_HUMANBioGRID23768491 details
PML_HUMANATRX_HUMANBioGRID23222847 details
PML_HUMANH33_HUMANBioGRID23222847 details
PML_HUMANHIRA_HUMANBioGRID23222847 details
PML_HUMANASF1A_HUMANBioGRID23222847 details
PML_HUMANRL5_HUMANBioGRID23169665 details
PML_HUMANTBX3_HUMANBioGRID22002537 details
PML_HUMANSKIL_HUMANBioGRID19745809 details
PML_HUMANTF7L2_HUMANBioGRID22155184 details
PML_HUMANPARK7_HUMANBioGRID22683601 details
PML_HUMANMLP3B_HUMANBioGRID25419843 details
PML_HUMANSTAT1_HUMANBioGRID25733689 25812002 details
PML_HUMANSTAT2_HUMANBioGRID25812002 details
PML_HUMANPRGC1_HUMANBioGRID26407237 details
PML_HUMANNR1I3_HUMANBioGRID26407237 details
PML_HUMANCDN2A_HUMANBioGRID26578773 details
PML_HUMANSPTA1_HUMANBioGRID16889989 details
PML_HUMANTRI22_HUMANBioGRID28555140 details
PML_HUMANC2TA_HUMANBioGRID28555140 details
PML_HUMANCACL1_HUMANBioGRID27889610 details
PML_HUMANPCBP1_HUMANBioGRID28963376 details
PML_HUMANIMA3_HUMANBioGRID28075463 details
PML_HUMANSP3_HUMANBioGRID15494207 details
PML_HUMANXRCC1_HUMANBioGRID30260704 details
PML_HUMANBUB3_HUMANBioGRID31911655 details
PML_HUMANCASP8_HUMANBioGRID31153006 details
PML_HUMANTGFR1_HUMANHPRD15356634 details
PML_HUMANTGFR2_HUMANHPRD15356634 details
PML_HUMANMAD1_HUMANHPRD11430826 details
PML_HUMANMK14_HUMANHPRD15273249 details
PML_HUMANP73_HUMANHPRD11832207 details
PML_HUMANSENP2_HUMANHPRD12419228 details
PML_HUMANTHA_HUMANHPRD10610177 details
PML_HUMANPAWR_HUMANHPRD12717420 details
PML_HUMANEP300_HUMANHPRD11940591 details