Entity Details

Primary name PRDX3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30048
EntryNamePRDX3_HUMAN
FullNameThioredoxin-dependent peroxide reductase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length256
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesPRDX3

GO terms

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GOName
GO:0001893 maternal placenta development
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005769 early endosome
GO:0005829 cytosol
GO:0006979 response to oxidative stress
GO:0007005 mitochondrion organization
GO:0008022 protein C-terminus binding
GO:0008284 positive regulation of cell population proliferation
GO:0008379 thioredoxin peroxidase activity
GO:0008785 alkyl hydroperoxide reductase activity
GO:0018171 peptidyl-cysteine oxidation
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0030099 myeloid cell differentiation
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0033673 negative regulation of kinase activity
GO:0034599 cellular response to oxidative stress
GO:0034614 cellular response to reactive oxygen species
GO:0042542 response to hydrogen peroxide
GO:0042744 hydrogen peroxide catabolic process
GO:0042802 identical protein binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045454 cell redox homeostasis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051881 regulation of mitochondrial membrane potential

Subcellular Location

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Subcellular Location
Cytoplasm
Early endosome
Mitochondrion

Domains

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DomainNameCategoryType
IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidantDomainDomain
IPR013766 Thioredoxin domainDomainDomain
IPR019479 Peroxiredoxin, C-terminalDomainDomain
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily

Diseases

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