Entity Details

Primary name PPIF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30405
EntryNamePPIF_HUMAN
FullNamePeptidyl-prolyl cis-trans isomerase F, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length207
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesPPIF

GO terms

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GOName
GO:0000413 protein peptidyl-prolyl isomerization
GO:0002931 response to ischemia
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005757 mitochondrial permeability transition pore complex
GO:0005759 mitochondrial matrix
GO:0006457 protein folding
GO:0008637 apoptotic mitochondrial changes
GO:0010849 regulation of proton-transporting ATPase activity, rotational mechanism
GO:0010939 regulation of necrotic cell death
GO:0016018 cyclosporin A binding
GO:0016020 membrane
GO:0032780 negative regulation of ATPase activity
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0046902 regulation of mitochondrial membrane permeability
GO:0070266 necroptotic process
GO:0070301 cellular response to hydrogen peroxide
GO:0071243 cellular response to arsenic-containing substance
GO:0071277 cellular response to calcium ion
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0090324 negative regulation of oxidative phosphorylation
GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death
GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domainDomainDomain
IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved siteSiteConserved site
IPR029000 Cyclophilin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00091 CyclosporineDrugbanksmall molecule
DB00172 ProlineDrugbanksmall molecule
DB02078 TriglymeDrugbanksmall molecule
DB08168 Coumarin 120Drugbanksmall molecule