Entity Details

Primary name SC5A2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP31639
EntryNameSC5A2_HUMAN
FullNameSodium/glucose cotransporter 2
TaxID9606
Evidenceevidence at transcript level
Length672
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesSLC5A2

GO terms

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GOName
GO:0000017 alpha-glucoside transport
GO:0005362 low-affinity glucose:sodium symporter activity
GO:0005412 glucose:sodium symporter activity
GO:0005886 plasma membrane
GO:0005975 carbohydrate metabolic process
GO:0006814 sodium ion transport
GO:0008645 hexose transmembrane transport
GO:0015151 alpha-glucoside transmembrane transporter activity
GO:0016021 integral component of membrane
GO:0055056 D-glucose transmembrane transporter activity
GO:0070062 extracellular exosome
GO:0098708 glucose import across plasma membrane
GO:0098719 sodium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR001734 Sodium/solute symporterFamilyFamily
IPR018212 Sodium/solute symporter, conserved siteSiteConserved site
IPR038377 Sodium/glucose symporter superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
233100 OMIMRenal glucosuria (GLYS)A disorder characterized by persistent isolated glucosuria, normal fasting serum glucose concentration, decreased renal tubular resorption of glucose from the urine, and absence of any other signs of tubular dysfunction. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01914 D-glucoseSwissprotsmall molecule
DB06292 DapagliflozinDrugbanksmall molecule
DB08907 CanagliflozinDrugbanksmall molecule
DB09038 EmpagliflozinDrugbanksmall molecule
DB11827 ErtugliflozinDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
SC5A2_HUMANAQP2_HUMANBioGRID28931009 details