Entity Details

Primary name NOS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35228
EntryNameNOS2_HUMAN
FullNameNitric oxide synthase, inducible
TaxID9606
Evidenceevidence at protein level
Length1153
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesNOS2

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0001912 positive regulation of leukocyte mediated cytotoxicity
GO:0002227 innate immune response in mucosa
GO:0004517 nitric-oxide synthase activity
GO:0005516 calmodulin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006527 arginine catabolic process
GO:0006801 superoxide metabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0006954 inflammatory response
GO:0007263 nitric oxide mediated signal transduction
GO:0007623 circadian rhythm
GO:0008104 protein localization
GO:0009617 response to bacterium
GO:0009725 response to hormone
GO:0010181 FMN binding
GO:0010629 negative regulation of gene expression
GO:0012506 vesicle membrane
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0018119 peptidyl-cysteine S-nitrosylation
GO:0019221 cytokine-mediated signaling pathway
GO:0020037 heme binding
GO:0030863 cortical cytoskeleton
GO:0031284 positive regulation of guanylate cyclase activity
GO:0032310 prostaglandin secretion
GO:0032496 response to lipopolysaccharide
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0034617 tetrahydrobiopterin binding
GO:0034618 arginine binding
GO:0035690 cellular response to drug
GO:0042127 regulation of cell population proliferation
GO:0042177 negative regulation of protein catabolic process
GO:0042742 defense response to bacterium
GO:0042803 protein homodimerization activity
GO:0043457 regulation of cellular respiration
GO:0045454 cell redox homeostasis
GO:0045776 negative regulation of blood pressure
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0050796 regulation of insulin secretion
GO:0050829 defense response to Gram-negative bacterium
GO:0051712 positive regulation of killing of cells of other organism
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to interferon-gamma
GO:1900015 regulation of cytokine production involved in inflammatory response

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001094 Flavodoxin-likeDomainDomain
IPR001433 Oxidoreductase FAD/NAD(P)-bindingDomainDomain
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductaseDomainDomain
IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-bindingDomainDomain
IPR004030 Nitric oxide synthase, N-terminalDomainDomain
IPR008254 Flavodoxin/nitric oxide synthaseDomainDomain
IPR012144 Nitric-oxide synthase, eukaryoteFamilyFamily
IPR017927 FAD-binding domain, ferredoxin reductase-typeDomainDomain
IPR017938 Riboflavin synthase-like beta-barrelFamilyHomologous superfamily
IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamilyFamilyHomologous superfamily
IPR029039 Flavoprotein-like superfamilyFamilyHomologous superfamily
IPR036119 Nitric oxide synthase, N-terminal domain superfamilyFamilyHomologous superfamily
IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00125 ArginineDrugbanksmall molecule
DB00155 CitrullineDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01017 MinocyclineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01234 DexamethasoneDrugbanksmall molecule
DB01686 N,N-dimethylarginineDrugbanksmall molecule
DB01835 4R-Fluoro-N6-ethanimidoyl-L-lysineDrugbanksmall molecule
DB01997 3-Bromo-7-NitroindazoleDrugbanksmall molecule
DB02044 N-[3-(aminomethyl)benzyl]acetamidineDrugbanksmall molecule
DB02207 7-NitroindazoleDrugbanksmall molecule
DB02234 S-EthylisothioureaDrugbanksmall molecule
DB02462 ThiocoumarinDrugbanksmall molecule
DB02644 N-omega-propyl-L-arginineDrugbanksmall molecule
DB03100 6-NitroindazoleDrugbanksmall molecule
DB03144 N(5)-[(hydroxyamino)(imino)methyl]-L-ornithineDrugbanksmall molecule
DB03366 ImidazoleDrugbanksmall molecule
DB03449 N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamideDrugbanksmall molecule
DB03953 ThiocitrullineDrugbanksmall molecule
DB04400 L-erythro-7,8-dihydrobiopterinDrugbanksmall molecule
DB04534 5-NitroindazoleDrugbanksmall molecule
DB05214 KD7040Drugbanksmall molecule
DB05252 Fenoxaprop-ethylDrugbanksmall molecule
DB05383 PimagedineDrugbanksmall molecule
DB06879 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILEDrugbanksmall molecule
DB06916 N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDEDrugbanksmall molecule
DB07002 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrileDrugbanksmall molecule
DB07003 (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amineDrugbanksmall molecule
DB07007 (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amineDrugbanksmall molecule
DB07008 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINEDrugbanksmall molecule
DB07011 (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINEDrugbanksmall molecule
DB07029 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINEDrugbanksmall molecule
DB07306 ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATEDrugbanksmall molecule
DB07318 N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDEDrugbanksmall molecule
DB07388 ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATEDrugbanksmall molecule
DB07389 N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDEDrugbanksmall molecule
DB07405 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINEDrugbanksmall molecule
DB08214 4-(1H-IMIDAZOL-1-YL)PHENOLDrugbanksmall molecule
DB08750 1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINEDrugbanksmall molecule
DB08814 TriflusalDrugbanksmall molecule
DB09237 LevamlodipineDrugbanksmall molecule
DB11327 DipyrithioneDrugbanksmall molecule
DB14649 Dexamethasone acetateDrugbanksmall molecule