Entity Details

Primary name RADI_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35241
EntryNameRADI_HUMAN
FullNameRadixin
TaxID9606
Evidenceevidence at protein level
Length583
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesRDX

GO terms

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GOName
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005912 adherens junction
GO:0005925 focal adhesion
GO:0008360 regulation of cell shape
GO:0008361 regulation of cell size
GO:0010628 positive regulation of gene expression
GO:0010737 protein kinase A signaling
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0030315 T-tubule
GO:0030335 positive regulation of cell migration
GO:0030496 midbody
GO:0030864 cortical actin cytoskeleton
GO:0032154 cleavage furrow
GO:0032231 regulation of actin filament bundle assembly
GO:0032487 regulation of Rap protein signal transduction
GO:0034111 negative regulation of homotypic cell-cell adhesion
GO:0034260 negative regulation of GTPase activity
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0043087 regulation of GTPase activity
GO:0045176 apical protein localization
GO:0045184 establishment of protein localization
GO:0045296 cadherin binding
GO:0045792 negative regulation of cell size
GO:0051016 barbed-end actin filament capping
GO:0051018 protein kinase A binding
GO:0051117 ATPase binding
GO:0051286 cell tip
GO:0061028 establishment of endothelial barrier
GO:0070062 extracellular exosome
GO:0071944 cell periphery
GO:0072659 protein localization to plasma membrane
GO:0097067 cellular response to thyroid hormone stimulus
GO:1900027 regulation of ruffle assembly
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1902115 regulation of organelle assembly
GO:1902966 positive regulation of protein localization to early endosome
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903392 negative regulation of adherens junction organization
GO:2000643 positive regulation of early endosome to late endosome transport

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cleavage furrow
Cytoplasm

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000798 Ezrin/radixin/moesin-likeFamilyFamily
IPR008954 Moesin tail domain superfamilyFamilyHomologous superfamily
IPR011174 Ezrin/radixin/moesinFamilyFamily
IPR011259 Ezrin/radixin/moesin, C-terminalDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR014352 FERM/acyl-CoA-binding protein superfamilyFamilyHomologous superfamily
IPR018979 FERM, N-terminalDomainDomain
IPR018980 FERM, C-terminal PH-like domainDomainDomain
IPR019747 FERM conserved siteSiteConserved site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR041789 ERM family, FERM domain C-lobeDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB03401 1D-myo-inositol 1,4,5-trisphosphateDrugbanksmall molecule