Entity Details

Primary name PCKGC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35558
EntryNamePCKGC_HUMAN
FullNamePhosphoenolpyruvate carboxykinase, cytosolic [GTP]
TaxID9606
Evidenceevidence at protein level
Length622
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesPCK1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006107 oxaloacetate metabolic process
GO:0007568 aging
GO:0014823 response to activity
GO:0018105 peptidyl-serine phosphorylation
GO:0019003 GDP binding
GO:0019543 propionate catabolic process
GO:0030145 manganese ion binding
GO:0030522 intracellular receptor signaling pathway
GO:0031406 carboxylic acid binding
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033993 response to lipid
GO:0042593 glucose homeostasis
GO:0042594 response to starvation
GO:0043382 positive regulation of memory T cell differentiation
GO:0046327 glycerol biosynthetic process from pyruvate
GO:0046890 regulation of lipid biosynthetic process
GO:0051365 cellular response to potassium ion starvation
GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH
GO:0070062 extracellular exosome
GO:0070365 hepatocyte differentiation
GO:0070741 response to interleukin-6
GO:0071300 cellular response to retinoic acid
GO:0071320 cellular response to cAMP
GO:0071332 cellular response to fructose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071377 cellular response to glucagon stimulus
GO:0071456 cellular response to hypoxia
GO:0071549 cellular response to dexamethasone stimulus
GO:0106264 protein serine kinase activity (using GTP as donor)
GO:1904640 response to methionine

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum

Domains

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DomainNameCategoryType
IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilisingFamilyFamily
IPR008210 Phosphoenolpyruvate carboxykinase, N-terminalFamilyHomologous superfamily
IPR013035 Phosphoenolpyruvate carboxykinase, C-terminalFamilyHomologous superfamily
IPR018091 Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved siteSiteConserved site
IPR035077 Phosphoenolpyruvate carboxykinase, C-terminal P-loop domainDomainDomain
IPR035078 Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00787 AcyclovirDrugbanksmall molecule
DB01819 PhosphoenolpyruvateDrugbanksmall molecule
DB02008 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-XanthineDrugbanksmall molecule
DB03267 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-XanthineDrugbanksmall molecule
DB03725 5'-GuanylylmethylenebisphosphonateDrugbanksmall molecule
DB09338 MersalylDrugbanksmall molecule