Entity Details

Primary name OPRK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41145
EntryNameOPRK_HUMAN
FullNameKappa-type opioid receptor
TaxID9606
Evidenceevidence at protein level
Length380
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesOPRK1

GO terms

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GOName
GO:0004930 G protein-coupled receptor activity
GO:0004985 G protein-coupled opioid receptor activity
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007600 sensory perception
GO:0007626 locomotory behavior
GO:0016021 integral component of membrane
GO:0019233 sensory perception of pain
GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway
GO:0038003 G protein-coupled opioid receptor signaling pathway
GO:0038048 dynorphin receptor activity
GO:0042277 peptide binding
GO:0042923 neuropeptide binding
GO:0043005 neuron projection
GO:0045202 synapse
GO:0046877 regulation of saliva secretion
GO:0051607 defense response to virus

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000452 Kappa opioid receptorFamilyFamily
IPR001418 Opioid receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00193 TramadolDrugbanksmall molecule
DB00289 AtomoxetineDrugbanksmall molecule
DB00295 MorphineDrugbanksmall molecule
DB00318 CodeineDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00327 HydromorphoneDrugbanksmall molecule
DB00370 MirtazapineDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00454 MeperidineDrugbanksmall molecule
DB00497 OxycodoneDrugbanksmall molecule
DB00514 DextromethorphanDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00611 ButorphanolDrugbanksmall molecule
DB00647 DextropropoxypheneDrugbanksmall molecule
DB00652 PentazocineDrugbanksmall molecule
DB00704 NaltrexoneDrugbanksmall molecule
DB00708 SufentanilDrugbanksmall molecule
DB00813 FentanylDrugbanksmall molecule
DB00825 LevomentholDrugbanksmall molecule
DB00836 LoperamideDrugbanksmall molecule
DB00844 NalbuphineDrugbanksmall molecule
DB00854 LevorphanolDrugbanksmall molecule
DB00899 RemifentanilDrugbanksmall molecule
DB00921 BuprenorphineDrugbanksmall molecule
DB01183 NaloxoneDrugbanksmall molecule
DB01209 DezocineDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01439 3-MethylthiofentanylDrugbanksmall molecule
DB01452 DiamorphineDrugbanksmall molecule
DB01497 EtorphineDrugbanksmall molecule
DB01535 CarfentanilDrugbanksmall molecule
DB01548 DiprenorphineDrugbanksmall molecule
DB01565 DihydromorphineDrugbanksmall molecule
DB01571 3-MethylfentanylDrugbanksmall molecule
DB05046 V1003Drugbanksmall molecule
DB05104 AsimadolineDrugbanksmall molecule
DB05155 CR665Drugbanksmall molecule
DB05443 ADL 10-0101Drugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06204 TapentadolDrugbanksmall molecule
DB06230 NalmefeneDrugbanksmall molecule
DB06274 AlvimopanDrugbanksmall molecule
DB06409 Morphine glucuronideDrugbanksmall molecule
DB06738 KetobemidoneDrugbanksmall molecule
DB06800 MethylnaltrexoneDrugbanksmall molecule
DB09173 ButyrfentanylDrugbanksmall molecule
DB09209 PholcodineDrugbanksmall molecule
DB09272 EluxadolineDrugbanksmall molecule
DB11130 OpiumDrugbanksmall molecule
DB11186 PentoxyverineDrugbanksmall molecule
DB11691 NaldemedineDrugbanksmall molecule
DB14146 LoxicodegolDrugbanksmall molecule