Entity Details

Primary name PI2R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43119
EntryNamePI2R_HUMAN
FullNameProstacyclin receptor
TaxID9606
Evidenceevidence at protein level
Length386
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesPTGIR

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0016501 prostacyclin receptor activity
GO:0032496 response to lipopolysaccharide
GO:0048662 negative regulation of smooth muscle cell proliferation

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000370 Prostacyclin (prostanoid IP) receptorFamilyFamily
IPR008365 Prostanoid receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00374 TreprostinilDrugbanksmall molecule
DB01088 IloprostDrugbanksmall molecule
DB01160 Dinoprost tromethamineDrugbanksmall molecule
DB01240 EpoprostenolDrugbanksmall molecule
DB05229 BeraprostDrugbanksmall molecule
DB11362 SelexipagDrugbanksmall molecule