Entity Details

Primary name MK08_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP45983
EntryNameMK08_HUMAN
FullNameMitogen-activated protein kinase 8
TaxID9606
Evidenceevidence at protein level
Length427
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesMAPK8

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0004705 JUN kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006302 double-strand break repair
GO:0006468 protein phosphorylation
GO:0006979 response to oxidative stress
GO:0007254 JNK cascade
GO:0007258 JUN phosphorylation
GO:0009411 response to UV
GO:0009612 response to mechanical stimulus
GO:0010628 positive regulation of gene expression
GO:0016241 regulation of macroautophagy
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019899 enzyme binding
GO:0030424 axon
GO:0031281 positive regulation of cyclase activity
GO:0031343 positive regulation of cell killing
GO:0032091 negative regulation of protein binding
GO:0032880 regulation of protein localization
GO:0034198 cellular response to amino acid starvation
GO:0034614 cellular response to reactive oxygen species
GO:0035033 histone deacetylase regulator activity
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042752 regulation of circadian rhythm
GO:0042826 histone deacetylase binding
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045202 synapse
GO:0048511 rhythmic process
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051247 positive regulation of protein metabolic process
GO:0051403 stress-activated MAPK cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071276 cellular response to cadmium ion
GO:0071345 cellular response to cytokine stimulus
GO:0090045 positive regulation of deacetylase activity
GO:0097441 basal dendrite
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1902595 regulation of DNA replication origin binding

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR003527 Mitogen-activated protein (MAP) kinase, conserved siteSiteConserved site
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR008351 Mitogen-activated protein (MAP) kinase, JNKFamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00675 TamoxifenDrugbanksmall molecule
DB01017 MinocyclineDrugbanksmall molecule
DB01782 PyrazolanthroneDrugbanksmall molecule
DB07218 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONEDrugbanksmall molecule
DB07268 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDEDrugbanksmall molecule
DB07272 N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDEDrugbanksmall molecule
DB07276 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDEDrugbanksmall molecule
DB07845 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamideDrugbanksmall molecule
DB15624 HalicinDrugbanksmall molecule

Interactions

178 interactions

InteractorPartnerSourcesPublicationsLink
MK08_HUMANBCL2_HUMANBioGRID, HPRD, MINT10567572 12039864 15225643 15733859 details
MK08_HUMANB2CL1_HUMANBioGRID, HPRD, IntAct, MINT15733859 22617334 25241761 details
MK08_HUMANJUN_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt10101227 10393177 10398438 10419510 10464310 10747973 10908726 10962563 10987838 11108663 11278395 11479302 11532856 11907583 12052834 12149229 12185592 12228228 12407442 12832416 12963725 13130464 14517282 14557262 14572659 14612408 14633987 14701799 15143066 15289320 15299005 15302935 15590691 15677475 15749833 15894542 15958389 16007099 16142216 16157600 16166642 16291755 16434970 16533805 16549498 16740711 16824735 16983342 17189706 17363973 17875713 18003900 18429822 18922473 18957422 19270716 19527717 19910486 20133937 20514406 20732415 22110360 22904686 23816567 25098452 7527398 8001819 8137421 8224842 8586671 8621542 8654373 8846788 9032244 9575168 9692890 9774977 9808624 9990010 details
MK08_HUMANMP2K7_HUMANBioGRID, HPRD, IntAct10713157 11062067 12821118 13130464 16533805 24975362 25241761 25284480 26364603 9207092 details
MK08_HUMANMP2K4_HUMANBioGRID, HPRD, IntAct10713157 11062067 11279118 11707464 12391307 12788955 13130464 15998799 16533805 9162092 9661668 9808624 details
MK08_HUMANATF2_HUMANBioGRID, HPRD, IntAct11279118 11566021 11865055 12804775 12874243 12958075 15550563 16533805 17875713 21444723 7535770 7737129 7737130 8654373 9162092 9207092 9399639 9405416 details
MK08_HUMANJIP1_HUMANBioGRID, HPRD, IntAct, MINT11700324 12756254 15998799 16343492 16533805 16840345 18286207 28514442 9733513 details
MK08_HUMANM3K7_HUMANBioGRID, HPRD, IntAct11865055 17709393 details
MK08_HUMANCBL_HUMANBioGRID, MINT11944898 16982329 details
MK08_HUMANCRK_HUMANBioGRID, HPRD, IntAct, MINT11432831 16982329 25241761 details
MK08_HUMANCAMP_HUMANBioGRID, IntAct21988832 details
MK08_HUMANGARS_HUMANBioGRID, IntAct21988832 details
MK08_HUMANGFPT1_HUMANBioGRID, IntAct21988832 details
MK08_HUMANMKNK2_HUMANBioGRID, IntAct21988832 details
MK08_HUMANGCYA1_HUMANBioGRID, IntAct21988832 details
MK08_HUMANDHB4_HUMANBioGRID, IntAct21988832 details
MK08_HUMANRAF1_HUMANBioGRID, IntAct21988832 details
MK08_HUMANRLA2_HUMANBioGRID, IntAct21988832 details
MK08_HUMANKS6B1_HUMANBioGRID, HPRD, IntAct11279232 21988832 23816567 details
MK08_HUMANGANAB_HUMANBioGRID, IntAct21988832 details
MK08_HUMANNKAP1_HUMANBioGRID, IntAct21988832 details
MK08_HUMANZEP1_HUMANBioGRID, IntAct21988832 details
MK08_HUMANID2_HUMANBioGRID, IntAct21988832 details
MK08_HUMANSSU72_HUMANBioGRID, IntAct21988832 details
MK08_HUMANSCOC_HUMANBioGRID, IntAct21988832 details
MK08_HUMANBMPR2_HUMANBioGRID, MINT21900206 details
MK08_HUMANDAPLE_HUMANBioGRID, MINT21900206 details
MK08_HUMANDUS8_HUMANBioGRID, IntAct, MINT21900206 26186194 27432908 27880917 28514442 details
MK08_HUMANF193B_HUMANBioGRID, MINT21900206 details
MK08_HUMANHSP7C_HUMANBioGRID, MINT21900206 details
MK08_HUMANPNRC1_HUMANBioGRID, MINT21900206 details
MK08_HUMANRBM15_HUMANBioGRID, MINT21900206 details
MK08_HUMANSCND1_HUMANBioGRID, MINT21900206 details
MK08_HUMANZN219_HUMANBioGRID, MINT21900206 details
MK08_HUMANDUS4_HUMANBioGRID, HPRD, MINT11387337 16038800 19843478 28675297 details
MK08_HUMANM3K1_HUMANBioGRID, IntAct12228228 14500727 15299005 21152872 25241761 9405400 details
MK08_HUMANGSTP1_HUMANBioGRID, HPRD, IntAct11279197 12646564 16636664 25241761 26429914 details
MK08_HUMANPAXI_HUMANBioGRID, HPRD, IntAct12853963 23397142 30120307 details
MK08_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
MK08_HUMANHNF4A_HUMANIntAct15550563 details
MK08_HUMANDUS10_HUMANBioGRID, HPRD, IntAct10391943 10597297 16166642 28675297 32296183 details
MK08_HUMANDUS16_HUMANBioGRID, HPRD, IntAct11489891 27432908 28675297 32296183 details
MK08_HUMANWDR62_HUMANBioGRID, IntAct19910486 26186194 28514442 details
MK08_HUMANH2AX_HUMANBioGRID, DIP17145805 19234442 20512932 details
MK08_HUMANHSF1_HUMANBioGRID, DIP, HPRD10747973 27043084 details
MK08_HUMANIRS1_HUMANBioGRID, HPRD10722755 11606564 12351658 12417588 details
MK08_HUMANSPIB_HUMANBioGRID, HPRD8632909 details
MK08_HUMANSPI1_HUMANBioGRID8632909 details
MK08_HUMAN3BP5_HUMANBioGRID, HPRD12167088 details
MK08_HUMANELP1_HUMANBioGRID, HPRD12058026 details
MK08_HUMANJUND_HUMANBioGRID, HPRD12052834 16264271 details
MK08_HUMANJIP3_HUMANBioGRID, HPRD10523642 10629060 12189133 16141199 details
MK08_HUMANPAX2_HUMANBioGRID, HPRD11700324 details
MK08_HUMANPRKDC_HUMANBioGRID, HPRD11749722 details
MK08_HUMANP53_HUMANBioGRID, HPRD11108663 11283254 12514174 15538975 18813780 19651615 9393873 9724739 9732264 details
MK08_HUMANREL_HUMANBioGRID, HPRD8621542 details
MK08_HUMANETV1_HUMANBioGRID11551945 details
MK08_HUMANELK1_HUMANBioGRID, HPRD17875713 8586671 8654373 8846788 details
MK08_HUMANDUS1_HUMANBioGRID, HPRD11278799 28675297 details
MK08_HUMANMYC_HUMANBioGRID, HPRD10551811 1748630 details
MK08_HUMANPDPK1_HUMANBioGRID10357815 details
MK08_HUMANNR4A1_HUMANBioGRID14612408 17023523 details
MK08_HUMANCEBPA_HUMANBioGRID16983342 details
MK08_HUMANCDN1A_HUMANBioGRID, HPRD12058028 20102411 details
MK08_HUMANSIR1_HUMANBioGRID20027304 details
MK08_HUMANHDAC9_HUMANBioGRID16611996 details
MK08_HUMANTFCP2_HUMANBioGRID15857981 details
MK08_HUMANNFE2_HUMANBioGRID19966288 details
MK08_HUMANPIAS2_HUMANBioGRID19815509 details
MK08_HUMANZN605_HUMANBioGRID21900206 details
MK08_HUMANSTAT3_HUMANBioGRID, HPRD10446219 10521505 11350938 12576423 12763138 14551213 15979846 9343414 9872331 details
MK08_HUMANNCOA3_HUMANBioGRID15383283 details
MK08_HUMANFZR1_HUMANBioGRID20581839 details
MK08_HUMANITCH_HUMANBioGRID16446428 details
MK08_HUMANRAD18_HUMANBioGRID22456510 details
MK08_HUMANM3K4_HUMANBioGRID21152872 26496610 details
MK08_HUMANSP1_HUMANBioGRID19245816 25398907 details
MK08_HUMANMK08_HUMANBioGRID20194509 23602568 31980649 details
MK08_HUMANMP2K1_HUMANBioGRID16533805 details
MK08_HUMANMP2K2_HUMANBioGRID16533805 details
MK08_HUMANCTNB1_HUMANBioGRID19667122 details
MK08_HUMANCDN1B_HUMANBioGRID12963725 details
MK08_HUMANA4_HUMANBioGRID12917434 21832049 details
MK08_HUMANGORS2_HUMANBioGRID11408587 details
MK08_HUMANIRF3_HUMANBioGRID19153595 details
MK08_HUMANAIMP1_HUMANBioGRID20510162 details
MK08_HUMANELK4_HUMANBioGRID9020136 details
MK08_HUMANB2L11_HUMANBioGRID, HPRD12591950 12818176 details
MK08_HUMANBMF_HUMANBioGRID, HPRD12591950 details
MK08_HUMANJKAMP_HUMANBioGRID, HPRD16166642 details
MK08_HUMANSIN1_HUMANBioGRID15722200 details
MK08_HUMANNFAC4_HUMANBioGRID17875713 details
MK08_HUMANNFAC3_HUMANBioGRID17875713 details
MK08_HUMANCASP3_HUMANBioGRID12821118 details
MK08_HUMANPMYT1_HUMANBioGRID19204086 details
MK08_HUMANSPB3_HUMANBioGRID16549498 details
MK08_HUMANSPB4_HUMANBioGRID16549498 details
MK08_HUMANCDN2A_HUMANBioGRID16007099 details
MK08_HUMANARF_HUMANBioGRID16007099 details
MK08_HUMANCDN2C_HUMANBioGRID16007099 details
MK08_HUMANWWOX_HUMANBioGRID, HPRD12514174 18371080 details
MK08_HUMANTAU_HUMANBioGRID15228592 9199504 details
MK08_HUMANAPLP2_HUMANBioGRID12917434 details
MK08_HUMANGEMI5_HUMANBioGRID17541429 details
MK08_HUMANNF2L2_HUMANBioGRID24704364 31945188 details
MK08_HUMAN1433Z_HUMANBioGRID, HPRD15696159 details
MK08_HUMANEP300_HUMANBioGRID11278389 details
MK08_HUMANAKT1_HUMANBioGRID20186153 details
MK08_HUMANMBP_HUMANBioGRID10978313 details
MK08_HUMANAPBB2_HUMANBioGRID17567906 details
MK08_HUMANMTA70_HUMANBioGRID33217317 details
MK08_HUMANP85A_HUMANHPRD, IntAct, MINT16982329 25284480 7642542 details
MK08_HUMANCRKL_HUMANMINT16982329 details
MK08_HUMANFLNB_HUMANBioGRID, MINT19270716 details
MK08_HUMANTNR6_HUMANBioGRID, IntAct15659383 25241761 details
MK08_HUMANTNFL6_HUMANBioGRID, IntAct15659383 25241761 details
MK08_HUMANRHOA_HUMANBioGRID, IntAct15659383 25241761 details
MK08_HUMANSMAD3_HUMANBioGRID, HPRD, IntAct10601313 25241761 details
MK08_HUMANBAD_HUMANHPRD, IntAct14967141 23397142 details
MK08_HUMANAPBB1_HUMANDIP19234442 details
MK08_HUMANRPTOR_HUMANBioGRID, DIP22493283 27043084 details
MK08_HUMANTR10B_HUMANBioGRID15659383 details
MK08_HUMANFADD_HUMANBioGRID15659383 details
MK08_HUMANBID_HUMANBioGRID15659383 details
MK08_HUMANEZRI_HUMANBioGRID15659383 details
MK08_HUMANGDIR1_HUMANBioGRID15659383 details
MK08_HUMANMOES_HUMANBioGRID15659383 details
MK08_HUMANCASPA_HUMANBioGRID15659383 details
MK08_HUMANCASP8_HUMANBioGRID15659383 details
MK08_HUMANTNR1A_HUMANBioGRID15659383 details
MK08_HUMANKPCD1_HUMANBioGRID, HPRD11948398 details
MK08_HUMANJIP4_HUMANBioGRID, HPRD12391307 details
MK08_HUMANBCAR1_HUMANBioGRID11432831 details
MK08_HUMANSYUG_HUMANBioGRID, HPRD12121974 details
MK08_HUMANSYUA_HUMANBioGRID12121974 details
MK08_HUMANJUNB_HUMANBioGRID, HPRD8917518 9405416 9889198 details
MK08_HUMANM3K2_HUMANBioGRID, HPRD10713157 details
MK08_HUMANHDAC1_HUMANBioGRID16611996 details
MK08_HUMANNFAC2_HUMANBioGRID15184502 details
MK08_HUMANK2C8_HUMANBioGRID, HPRD11781324 11788583 9211903 details
MK08_HUMANMTOR_HUMANBioGRID22493283 details
MK08_HUMANTRAF2_HUMANBioGRID9692890 details
MK08_HUMANSTAB2_HUMANBioGRID18387958 details
MK08_HUMANDCP1A_HUMANBioGRID19910486 details
MK08_HUMANRB_HUMANBioGRID11566021 details
MK08_HUMANATF7_HUMANBioGRID11566021 details
MK08_HUMANVANG2_HUMANBioGRID26754771 details
MK08_HUMANMK14_HUMANBioGRID, HPRD15778365 18586681 details
MK08_HUMANBANP_HUMANBioGRID28617439 details
MK08_HUMANHS90A_HUMANBioGRID17891170 details
MK08_HUMANFAK1_HUMANBioGRID16141199 details
MK08_HUMANBAX_HUMANBioGRID19910452 details
MK08_HUMANBAK_HUMANBioGRID19910452 details
MK08_HUMANSH3R3_HUMANBioGRID32427938 details
MK08_HUMANRET_HUMANHPRD16153436 details
MK08_HUMANRASH_HUMANHPRD11525649 16810318 8137421 details
MK08_HUMANELK3_HUMANHPRD11042694 details
MK08_HUMANPPARG_HUMANHPRD9030579 details
MK08_HUMANTNF11_HUMANHPRD9396779 details
MK08_HUMANEF2K_HUMANHPRD12171600 details
MK08_HUMANI27RA_HUMANHPRD12734330 details
MK08_HUMANJIP2_HUMANHPRD10490659 10756100 details
MK08_HUMANDUS22_HUMANHPRD12138158 details
MK08_HUMANJDP2_HUMANHPRD11602244 12225289 details
MK08_HUMANMABP1_HUMANHPRD10471813 details
MK08_HUMANCSN2_HUMANHPRD10585392 details
MK08_HUMANDUS7_HUMANHPRD9788880 details
MK08_HUMANMK03_HUMANHPRD15778365 details
MK08_HUMANMK01_HUMANHPRD15778365 details
MK08_HUMANSMAD2_HUMANHPRD15326485 details
MK08_HUMANHSF4_HUMANHPRD16581800 details
MK08_HUMANRASF1_HUMANHPRD16810318 details
MK08_HUMANSHC1_HUMANHPRD15688026 details
MK08_HUMANP73_HUMANHPRD15483136 details
MK08_HUMANTRAF6_HUMANHPRD10346818 details
MK08_HUMANGCR_HUMANHPRD12351702 9199329 details
MK08_HUMANXRCC6_HUMANHPRD11749722 details
MK08_HUMANMAP1B_HUMANHPRD12689591 details