Entity Details

Primary name MP2K3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP46734
EntryNameMP2K3_HUMAN
FullNameDual specificity mitogen-activated protein kinase kinase 3
TaxID9606
Evidenceevidence at protein level
Length347
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesMAP2K3

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001817 regulation of cytokine production
GO:0004708 MAP kinase kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0016020 membrane
GO:0019901 protein kinase binding
GO:0035331 negative regulation of hippo signaling
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038066 p38MAPK cascade
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045860 positive regulation of protein kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060048 cardiac muscle contraction
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

62 interactions

InteractorPartnerSourcesPublicationsLink
MP2K3_HUMANDYR1B_HUMANIntAct11980910 details
MP2K3_HUMANMK14_HUMANBioGRID, IntAct, MINT11279118 17255949 20213747 23602568 23904011 26186194 28205554 28514442 28628118 31980649 9162092 details
MP2K3_HUMANALDOC_HUMANBioGRID, IntAct21988832 details
MP2K3_HUMANM3K5_HUMANBioGRID, DIP, IntAct16709866 19805025 21771788 28205554 31980649 details
MP2K3_HUMANRL13_HUMANBioGRID, MINT21900206 27684187 details
MP2K3_HUMANLRRK2_HUMANBioGRID, IntAct19302196 20067578 20173330 details
MP2K3_HUMANTAOK2_HUMANBioGRID, IntAct11279118 25241761 details
MP2K3_HUMANM3K4_HUMANBioGRID, IntAct15866172 25241761 9841871 details
MP2K3_HUMANMP2K6_HUMANBioGRID, IntAct25241761 26186194 28205554 28514442 details
MP2K3_HUMANTINF2_HUMANbhf-ucl, BioGRID21044950 details
MP2K3_HUMANMK03_HUMANBioGRID8226933 details
MP2K3_HUMANPLCB2_HUMANBioGRID12054652 details
MP2K3_HUMANM3K2_HUMANBioGRID9162092 details
MP2K3_HUMANMP2K3_HUMANBioGRID28205554 31980649 9162092 details
MP2K3_HUMANM3K3_HUMANBioGRID9162092 details
MP2K3_HUMANA4_HUMANBioGRID21832049 details
MP2K3_HUMANARRB1_HUMANBioGRID16709866 details
MP2K3_HUMANMYC_HUMANBioGRID28205554 28628118 29467282 details
MP2K3_HUMANARAF_HUMANBioGRID28205554 details
MP2K3_HUMANBECN1_HUMANBioGRID28205554 28628118 details
MP2K3_HUMANEPHA2_HUMANBioGRID28205554 28628118 details
MP2K3_HUMANFGFR4_HUMANBioGRID28205554 28628118 details
MP2K3_HUMANAKT1_HUMANBioGRID28205554 details
MP2K3_HUMANARNT_HUMANBioGRID28205554 28628118 details
MP2K3_HUMANAURKA_HUMANBioGRID28205554 28628118 details
MP2K3_HUMANCCND2_HUMANBioGRID28205554 details
MP2K3_HUMANCDK4_HUMANBioGRID28205554 details
MP2K3_HUMANCDK6_HUMANBioGRID28205554 details
MP2K3_HUMANMP2K5_HUMANBioGRID28205554 details
MP2K3_HUMANMERL_HUMANBioGRID28205554 details
MP2K3_HUMANPGFRA_HUMANBioGRID28205554 28628118 details
MP2K3_HUMANRAF1_HUMANBioGRID28205554 details
MP2K3_HUMANRASF1_HUMANBioGRID28205554 28628118 details
MP2K3_HUMANSTK11_HUMANBioGRID28205554 28628118 details
MP2K3_HUMANBRAF_HUMANBioGRID28205554 details
MP2K3_HUMANCBLC_HUMANBioGRID28205554 details
MP2K3_HUMANFZR1_HUMANBioGRID28205554 details
MP2K3_HUMANGLIS2_HUMANBioGRID28205554 details
MP2K3_HUMANERD22_HUMANBioGRID28205554 details
MP2K3_HUMANLATS2_HUMANBioGRID28205554 details
MP2K3_HUMANCD44_HUMANBioGRID28205554 details
MP2K3_HUMANCDC42_HUMANBioGRID28205554 details
MP2K3_HUMANCDN2B_HUMANBioGRID28205554 details
MP2K3_HUMANCDN2C_HUMANBioGRID28205554 details
MP2K3_HUMANERBB2_HUMANBioGRID28205554 details
MP2K3_HUMANHIF1A_HUMANBioGRID28205554 details
MP2K3_HUMANKAT2A_HUMANBioGRID28205554 details
MP2K3_HUMANMET_HUMANBioGRID28205554 details
MP2K3_HUMANNF1_HUMANBioGRID28205554 details
MP2K3_HUMANNFIC_HUMANBioGRID28205554 details
MP2K3_HUMANPTEN_HUMANBioGRID28205554 details
MP2K3_HUMANSMAD1_HUMANBioGRID28205554 details
MP2K3_HUMANTEAD2_HUMANBioGRID28205554 details
MP2K3_HUMANTERT_HUMANBioGRID28205554 details
MP2K3_HUMANP53_HUMANBioGRID28205554 details
MP2K3_HUMANPKN1_HUMANBioGRID, IntAct12761180 details
MP2K3_HUMANSMAD7_HUMANBioGRID12589052 details
MP2K3_HUMANJIP2_HUMANBioGRID12024021 20173330 details
MP2K3_HUMANPTPA_HUMANBioGRID17438131 details
MP2K3_HUMANJIP1_HUMANBioGRID20173330 details
MP2K3_HUMANJIP3_HUMANBioGRID20173330 details
MP2K3_HUMANJIP4_HUMANBioGRID20173330 details