Entity Details

Primary name 3HAO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP46952
EntryName3HAO_HUMAN
FullName3-hydroxyanthranilate 3,4-dioxygenase
TaxID9606
Evidenceevidence at protein level
Length286
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesHAAO

GO terms

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GOName
GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006569 tryptophan catabolic process
GO:0008198 ferrous iron binding
GO:0009055 electron transfer activity
GO:0009435 NAD biosynthetic process
GO:0010043 response to zinc ion
GO:0019805 quinolinate biosynthetic process
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
GO:0043420 anthranilate metabolic process
GO:0046686 response to cadmium ion
GO:0046874 quinolinate metabolic process
GO:0070050 neuron cellular homeostasis

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR010329 3-hydroxyanthranilic acid dioxygenaseFamilyFamily
IPR011051 RmlC-like cupin domain superfamilyFamilyHomologous superfamily
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR016700 3-hydroxyanthranilate 3, 4-dioxygenase, metazoanFamilyFamily

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
3HAO_HUMANDCE1_HUMANBioGRID, HPRD, IntAct16189514 25416956 31515488 32296183 details
3HAO_HUMANGDIR1_HUMANBioGRID, MINT21900206 details
3HAO_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 details
3HAO_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details