Entity Details

Primary name PPT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP50897
EntryNamePPT1_HUMAN
FullNamePalmitoyl-protein thioesterase 1
TaxID9606
Evidenceevidence at protein level
Length306
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPPT1

GO terms

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GOName
GO:0002084 protein depalmitoylation
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006898 receptor-mediated endocytosis
GO:0006907 pinocytosis
GO:0007042 lysosomal lumen acidification
GO:0007399 nervous system development
GO:0007420 brain development
GO:0007601 visual perception
GO:0008021 synaptic vesicle
GO:0008474 palmitoyl-(protein) hydrolase activity
GO:0015031 protein transport
GO:0016020 membrane
GO:0016042 lipid catabolic process
GO:0016290 palmitoyl-CoA hydrolase activity
GO:0016790 thiolester hydrolase activity
GO:0030149 sphingolipid catabolic process
GO:0030163 protein catabolic process
GO:0030308 negative regulation of cell growth
GO:0030424 axon
GO:0031579 membrane raft organization
GO:0035727 lysophosphatidic acid binding
GO:0043066 negative regulation of apoptotic process
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0043524 negative regulation of neuron apoptotic process
GO:0045121 membrane raft
GO:0046949 fatty-acyl-CoA biosynthetic process
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0048549 positive regulation of pinocytosis
GO:0048666 neuron development
GO:0050803 regulation of synapse structure or activity
GO:0050896 response to stimulus
GO:0070062 extracellular exosome
GO:0120146 sulfatide binding

Subcellular Location

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Subcellular Location
Lysosome
Secreted

Domains

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DomainNameCategoryType
IPR002472 Palmitoyl protein thioesteraseFamilyFamily
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily
IPR030294 Palmitoyl-protein thioesterase 1FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB02035 Hexadecanesulfonyl fluorideDrugbanksmall molecule
DB03796 Palmitic AcidDrugbanksmall molecule