Entity Details

Primary name AT1A2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP50993
EntryNameAT1A2_HUMAN
FullNameSodium/potassium-transporting ATPase subunit alpha-2
TaxID9606
Evidenceevidence at protein level
Length1020
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesATP1A2

GO terms

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GOName
GO:0001504 neurotransmitter uptake
GO:0001662 behavioral fear response
GO:0002026 regulation of the force of heart contraction
GO:0002087 regulation of respiratory gaseous exchange by nervous system process
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005496 steroid binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0005901 caveola
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006883 cellular sodium ion homeostasis
GO:0006937 regulation of muscle contraction
GO:0006940 regulation of smooth muscle contraction
GO:0006942 regulation of striated muscle contraction
GO:0008217 regulation of blood pressure
GO:0008344 adult locomotory behavior
GO:0008542 visual learning
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010996 response to auditory stimulus
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016791 phosphatase activity
GO:0016887 ATP hydrolysis activity
GO:0019229 regulation of vasoconstriction
GO:0019829 ATPase-coupled cation transmembrane transporter activity
GO:0021764 amygdala development
GO:0021989 olfactory cortex development
GO:0030007 cellular potassium ion homeostasis
GO:0030315 T-tubule
GO:0030955 potassium ion binding
GO:0031090 organelle membrane
GO:0031402 sodium ion binding
GO:0034220 ion transmembrane transport
GO:0035094 response to nicotine
GO:0035641 locomotory exploration behavior
GO:0035725 sodium ion transmembrane transport
GO:0036376 sodium ion export across plasma membrane
GO:0040011 locomotion
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0045822 negative regulation of heart contraction
GO:0045823 positive regulation of heart contraction
GO:0045988 negative regulation of striated muscle contraction
GO:0046034 ATP metabolic process
GO:0046982 protein heterodimerization activity
GO:0051087 chaperone binding
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051946 regulation of glutamate uptake involved in transmission of nerve impulse
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0055119 relaxation of cardiac muscle
GO:0060048 cardiac muscle contraction
GO:0071260 cellular response to mechanical stimulus
GO:0071383 cellular response to steroid hormone stimulus
GO:0071805 potassium ion transmembrane transport
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086009 membrane repolarization
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:0098655 cation transmembrane transport
GO:0150104 transport across blood-brain barrier
GO:1902600 proton transmembrane transport
GO:1903170 negative regulation of calcium ion transmembrane transport
GO:1903280 negative regulation of calcium:sodium antiporter activity
GO:1903416 response to glycoside
GO:1903561 extracellular vesicle
GO:1903779 regulation of cardiac conduction
GO:1990239 steroid hormone binding
GO:1990573 potassium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Cell membrane
Membrane

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR004014 Cation-transporting P-type ATPase, N-terminalDomainDomain
IPR005775 P-type ATPase subfamily IIC, subunit alphaFamilyFamily
IPR006068 Cation-transporting P-type ATPase, C-terminalDomainDomain
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01092 OuabainDrugbanksmall molecule
DB09479 Rubidium Rb-82Swissprotsmall molecule

Interactions

4 interactions