Entity Details

Primary name KCNQ1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51787
EntryNameKCNQ1_HUMAN
FullNamePotassium voltage-gated channel subfamily KQT member 1
TaxID9606
Evidenceevidence at protein level
Length676
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesKCNQ1

GO terms

Show/Hide Table
GOName
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005516 calmodulin binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0006349 regulation of gene expression by genetic imprinting
GO:0007605 sensory perception of sound
GO:0008016 regulation of heart contraction
GO:0008076 voltage-gated potassium channel complex
GO:0008157 protein phosphatase 1 binding
GO:0010460 positive regulation of heart rate
GO:0015271 outward rectifier potassium channel activity
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016458 gene silencing
GO:0030659 cytoplasmic vesicle membrane
GO:0034236 protein kinase A catalytic subunit binding
GO:0034237 protein kinase A regulatory subunit binding
GO:0034702 ion channel complex
GO:0035690 cellular response to drug
GO:0044325 transmembrane transporter binding
GO:0045121 membrane raft
GO:0048839 inner ear development
GO:0050892 intestinal absorption
GO:0060048 cardiac muscle contraction
GO:0060306 regulation of membrane repolarization
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization
GO:0060452 positive regulation of cardiac muscle contraction
GO:0060453 regulation of gastric acid secretion
GO:0061337 cardiac conduction
GO:0070293 renal absorption
GO:0071320 cellular response to cAMP
GO:0071805 potassium ion transmembrane transport
GO:0071872 cellular response to epinephrine stimulus
GO:0072359 circulatory system development
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
GO:0086011 membrane repolarization during action potential
GO:0086013 membrane repolarization during cardiac muscle cell action potential
GO:0086014 atrial cardiac muscle cell action potential
GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
GO:0086091 regulation of heart rate by cardiac conduction
GO:0097110 scaffold protein binding
GO:0097623 potassium ion export across plasma membrane
GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential
GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential
GO:1901381 positive regulation of potassium ion transmembrane transport
GO:1902260 negative regulation of delayed rectifier potassium channel activity
GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO:1903817 negative regulation of voltage-gated potassium channel activity

Subcellular Location

Show/Hide Table
Subcellular Location
Basolateral cell membrane
Cell membrane
Cytoplasmic vesicle membrane
Early endosome
Endoplasmic reticulum
Membrane raft

Domains

Show/Hide Table
DomainNameCategoryType
IPR003937 Potassium channel, voltage dependent, KCNQFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR005827 Potassium channel, voltage dependent, KCNQ1FamilyFamily
IPR013821 Potassium channel, voltage dependent, KCNQ, C-terminalDomainDomain
IPR028325 Voltage-gated potassium channelFamilyFamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00228 EnfluraneDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01244 BepridilDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB04957 AzimilideDrugbanksmall molecule
DB06089 ICA-105665Drugbanksmall molecule
DB11633 IsavuconazoleDrugbanksmall molecule