Entity Details

Primary name P5CS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP54886
EntryNameP5CS_HUMAN
FullNameDelta-1-pyrroline-5-carboxylate synthase
TaxID9606
Evidenceevidence at protein level
Length795
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesALDH18A1

GO terms

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GOName
GO:0003723 RNA binding
GO:0004349 glutamate 5-kinase activity
GO:0004350 glutamate-5-semialdehyde dehydrogenase activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0006536 glutamate metabolic process
GO:0006561 proline biosynthetic process
GO:0006592 ornithine biosynthetic process
GO:0009064 glutamine family amino acid metabolic process
GO:0019240 citrulline biosynthetic process
GO:0042802 identical protein binding
GO:0055129 L-proline biosynthetic process

Subcellular Location

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Subcellular Location
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR000965 GPR domainDomainDomain
IPR001048 Aspartate/glutamate/uridylate kinaseDomainDomain
IPR001057 Glutamate/acetylglutamate kinaseFamilyFamily
IPR005715 Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthaseFamilyFamily
IPR005766 Delta l-pyrroline-5-carboxylate synthetaseFamilyFamily
IPR015590 Aldehyde dehydrogenase domainDomainDomain
IPR016161 Aldehyde/histidinol dehydrogenaseFamilyHomologous superfamily
IPR016162 Aldehyde dehydrogenase, N-terminalFamilyHomologous superfamily
IPR016163 Aldehyde dehydrogenase, C-terminalFamilyHomologous superfamily
IPR019797 Glutamate 5-kinase, conserved siteSiteConserved site
IPR020593 Gamma-glutamyl phosphate reductase GPR, conserved siteSiteConserved site
IPR036393 Acetylglutamate kinase-like superfamilyFamilyHomologous superfamily
IPR041744 Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule