Entity Details

Primary name NCS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP62166
EntryNameNCS1_HUMAN
FullNameNeuronal calcium sensor 1
TaxID9606
Evidenceevidence at protein level
Length190
SequenceStatuscomplete
DateCreated2004-06-21
DateModified2021-06-02

Ontological Relatives

GenesNCS1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0005245 voltage-gated calcium channel activity
GO:0005509 calcium ion binding
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0010975 regulation of neuron projection development
GO:0014069 postsynaptic density
GO:0019901 protein kinase binding
GO:0030425 dendrite
GO:0031045 dense core granule
GO:0043231 intracellular membrane-bounded organelle
GO:0044305 calyx of Held
GO:0045921 positive regulation of exocytosis
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048471 perinuclear region of cytoplasm
GO:0098978 glutamatergic synapse
GO:0099523 presynaptic cytosol
GO:0099524 postsynaptic cytosol
GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Golgi apparatus
Membrane

Domains

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DomainNameCategoryType
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR028846 Recoverin familyFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB11093 Calcium citrateDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
NCS1_HUMANSIGL9_HUMANBioGRID, IntAct32296183 details
NCS1_HUMANPI4KB_HUMANBioGRID, HPRD11526106 12244129 14607934 details
NCS1_HUMANCTG1B_HUMANBioGRID, IntAct32296183 details
NCS1_HUMANMID49_HUMANBioGRID, IntAct32296183 details
NCS1_HUMANRNH1_HUMANBioGRID, IntAct32296183 details
NCS1_HUMANMEOX2_HUMANBioGRID32296183 details
NCS1_HUMANFZD7_HUMANBioGRID, IntAct32296183 details
NCS1_HUMANDRD2_HUMANBioGRID, HPRD12351722 14709338 21875085 details
NCS1_HUMANCEP89_HUMANBioGRID, IntAct26638075 32296183 details
NCS1_HUMANPRDM4_HUMANBioGRID, IntAct32296183 details
NCS1_HUMANSFPA2_HUMANBioGRID, IntAct32296183 details
NCS1_HUMANCREM_HUMANBioGRID, IntAct32296183 details
NCS1_HUMANLY66D_HUMANBioGRID, IntAct32296183 details
NCS1_HUMANOSTP_HUMANBioGRID, IntAct32296183 details
NCS1_HUMANC1QT2_HUMANBioGRID, IntAct32296183 details
NCS1_HUMANSPRE2_HUMANBioGRID, IntAct32296183 details
NCS1_HUMANDTX2_HUMANBioGRID, HPRD, IntAct, MINT16189514 21516116 25416956 32296183 details
NCS1_HUMANDRD3_HUMANBioGRID, HPRD12351722 details
NCS1_HUMANIRPL1_HUMANBioGRID, HPRD12783849 details
NCS1_HUMANNBL1_HUMANBioGRID, IntAct25416956 details
NCS1_HUMANZC3HA_HUMANBioGRID, IntAct32296183 details
NCS1_HUMANOXER1_HUMANBioGRID, IntAct32296183 details
NCS1_HUMANCDSN_HUMANBioGRID32296183 details
NCS1_HUMANDRD5_HUMANHPRD12351722 details
NCS1_HUMANCNR1_HUMANIntAct30073165 details
NCS1_HUMANARBK1_HUMANHPRD12351722 details
NCS1_HUMANKCND2_HUMANBioGRID, HPRD11606724 details
NCS1_HUMANNCS1_HUMANBioGRID21875085 details