Entity Details

Primary name UBE2B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP63146
EntryNameUBE2B_HUMAN
FullNameUbiquitin-conjugating enzyme E2 B
TaxID9606
Evidenceevidence at protein level
Length152
SequenceStatuscomplete
DateCreated2004-09-27
DateModified2021-06-02

Ontological Relatives

GenesUBE2B

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0000785 chromatin
GO:0001701 in utero embryonic development
GO:0001741 XY body
GO:0004842 ubiquitin-protein transferase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006281 DNA repair
GO:0006301 postreplication repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0006974 cellular response to DNA damage stimulus
GO:0007283 spermatogenesis
GO:0007288 sperm axoneme assembly
GO:0009411 response to UV
GO:0010845 positive regulation of reciprocal meiotic recombination
GO:0016567 protein ubiquitination
GO:0016574 histone ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0033128 negative regulation of histone phosphorylation
GO:0033503 HULC complex
GO:0033522 histone H2A ubiquitination
GO:0042493 response to drug
GO:0042769 DNA damage response, detection of DNA damage
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0045141 meiotic telomere clustering
GO:0050821 protein stabilization
GO:0051026 chiasma assembly
GO:0051865 protein autoubiquitination
GO:0061631 ubiquitin conjugating enzyme activity
GO:0070076 histone lysine demethylation
GO:0070193 synaptonemal complex organization
GO:0070534 protein K63-linked ubiquitination
GO:0070829 heterochromatin maintenance
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0090263 positive regulation of canonical Wnt signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000608 Ubiquitin-conjugating enzyme E2DomainDomain
IPR016135 Ubiquitin-conjugating enzyme/RWD-likeFamilyHomologous superfamily
IPR023313 Ubiquitin-conjugating enzyme, active siteSiteActive site

Diseases

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Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
UBE2B_HUMANUBC_HUMANBioGRID, MINT10388568 17550899 25582440 27182664 details
UBE2B_HUMANDPYL1_HUMANBioGRID, HPRD, IntAct16169070 details
UBE2B_HUMANUBR1_HUMANBioGRID, DIP, HPRD, IntAct16169070 21422291 25582440 details
UBE2B_HUMANMED31_HUMANBioGRID, HPRD, IntAct16169070 details
UBE2B_HUMANU119A_HUMANBioGRID, HPRD, IntAct16169070 details
UBE2B_HUMANUBR4_HUMANBioGRID, IntAct19549727 25582440 details
UBE2B_HUMANIRF7_HUMANIntAct19549727 details
UBE2B_HUMANRAD18_HUMANBioGRID, DIP, HPRD, IntAct10884424 10908344 15359278 17720710 18245774 18316726 19549727 20064529 20675655 21422291 21549715 21858012 24958773 25582440 27377895 27569044 28514442 30367120 31873223 details
UBE2B_HUMANUBR3_HUMANBioGRID, IntAct19549727 21816346 25582440 details
UBE2B_HUMANBRE1B_HUMANBioGRID, IntAct19410543 25582440 27569044 details
UBE2B_HUMANBRE1A_HUMANBioGRID, IntAct19410543 21443952 25582440 27569044 28514442 details
UBE2B_HUMANDDT4L_HUMANIntAct32296183 details
UBE2B_HUMANHERP2_HUMANBioGRID, IntAct32296183 details
UBE2B_HUMANH2A3_HUMANDIP20080676 details
UBE2B_HUMANUBR2_HUMANBioGRID, HPRD14585983 20080676 25582440 32366662 details
UBE2B_HUMANCDN1B_HUMANBioGRID19123975 details
UBE2B_HUMANPCNA_HUMANBioGRID15359278 20064529 details
UBE2B_HUMANBIRC2_HUMANBioGRID21113135 details
UBE2B_HUMANH2A2C_HUMANBioGRID20080676 23339190 details
UBE2B_HUMANCTNB1_HUMANBioGRID18339854 22705350 details
UBE2B_HUMANUBA1_HUMANBioGRID17597759 21041297 22069333 25527291 27425610 30279270 31873223 details
UBE2B_HUMANZMYM2_HUMANBioGRID12776193 details
UBE2B_HUMANTRI45_HUMANBioGRID24681954 details
UBE2B_HUMANUBR5_HUMANBioGRID11714696 details
UBE2B_HUMANUBE2B_HUMANBioGRID20061386 31873223 details
UBE2B_HUMANCBX5_HUMANBioGRID25384975 details
UBE2B_HUMANRC3H2_HUMANBioGRID26489670 details
UBE2B_HUMANRC3H1_HUMANBioGRID26489670 details
UBE2B_HUMANRNF4_HUMANBioGRID27678051 details
UBE2B_HUMANPRKN_HUMANBioGRID24647965 details
UBE2B_HUMANTRI14_HUMANBioGRID29053956 details
UBE2B_HUMANCNOT4_HUMANHPRD15001359 details
UBE2B_HUMANPOLH_HUMANBioGRID16824193 details
UBE2B_HUMANNBN_HUMANBioGRID21884979 details
UBE2B_HUMANP53_HUMANBioGRID22083959 details
UBE2B_HUMANMDM2_HUMANBioGRID22083959 details