Entity Details

Primary name PP2AA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP67775
EntryNamePP2AA_HUMAN
FullNameSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
TaxID9606
Evidenceevidence at protein level
Length309
SequenceStatuscomplete
DateCreated2004-10-11
DateModified2021-06-02

Ontological Relatives

GenesPPP2CA

GO terms

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GOName
GO:0000159 protein phosphatase type 2A complex
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000188 obsolete inactivation of MAPK activity
GO:0000775 chromosome, centromeric region
GO:0000922 spindle pole
GO:0001932 regulation of protein phosphorylation
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006275 regulation of DNA replication
GO:0006355 regulation of transcription, DNA-templated
GO:0006470 protein dephosphorylation
GO:0006672 ceramide metabolic process
GO:0006915 apoptotic process
GO:0007084 mitotic nuclear membrane reassembly
GO:0007498 mesoderm development
GO:0008022 protein C-terminus binding
GO:0008380 RNA splicing
GO:0010033 response to organic substance
GO:0010288 response to lead ion
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0019932 second-messenger-mediated signaling
GO:0030111 regulation of Wnt signaling pathway
GO:0030155 regulation of cell adhesion
GO:0030308 negative regulation of cell growth
GO:0035970 peptidyl-threonine dephosphorylation
GO:0040008 regulation of growth
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045595 regulation of cell differentiation
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0048156 tau protein binding
GO:0050811 GABA receptor binding
GO:0051321 meiotic cell cycle
GO:0070062 extracellular exosome
GO:0070262 peptidyl-serine dephosphorylation
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1904526 regulation of microtubule binding
GO:1904528 positive regulation of microtubule binding

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004843 Calcineurin-like phosphoesterase domain, ApaH typeDomainDomain
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphataseDomainDomain
IPR029052 Metallo-dependent phosphatase-likeFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00163 Vitamin EDrugbanksmall molecule
DB02506 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic AcidDrugbanksmall molecule
DB06905 (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acidDrugbanksmall molecule

Interactions

186 interactions

InteractorPartnerSourcesPublicationsLink
PP2AA_HUMANBCL2_HUMANBioGRID, HPRD, MINT15225643 9852076 details
PP2AA_HUMANPTN_HUMANBioGRID, HPRD, IntAct16169070 details
PP2AA_HUMANINO1_HUMANBioGRID, HPRD, IntAct16169070 details
PP2AA_HUMANRT26_HUMANBioGRID, HPRD, IntAct16169070 details
PP2AA_HUMANPCH2_HUMANBioGRID, HPRD, IntAct16189514 19060904 32296183 details
PP2AA_HUMANAKT1_HUMANBioGRID, DIP, HPRD, MINT11438723 11839802 12637511 16044149 18191226 20005908 20186153 26256536 27563096 details
PP2AA_HUMAN2A5B_HUMANBioGRID, HPRD, IntAct, MINT16456541 18782753 22379092 27880917 28330616 7592815 8703017 details
PP2AA_HUMAN2A5G_HUMANBioGRID, DIP, HPRD, I2D, IntAct, MINT10675325 11929880 1328865 15380617 16456541 18782753 19156129 19915589 21460856 26344197 27880917 28330616 7592815 8703017 details
PP2AA_HUMAN2AAA_HUMANBioGRID, DIP, HPRD, IntAct10191253 12370081 15761952 17055435 17274953 17374643 17529992 17540176 17632056 18394995 18715871 18782753 19156129 19293187 19818709 19915589 21159657 21460856 22167190 22379092 22863883 22939629 23443559 24841198 25438055 26344197 26496610 27880917 28330616 8617797 details
PP2AA_HUMAN2AAB_HUMANBioGRID, HPRD, IntAct, MINT12370081 17540176 18715871 18782753 19156129 22939629 26344197 26496610 28330616 8392071 details
PP2AA_HUMANRGAP1_HUMANHPRD, MINT18201571 details
PP2AA_HUMANPPME1_HUMANBioGRID, IntAct18782753 19156129 22167190 24841198 26186194 26499835 27880917 28330616 28514442 details
PP2AA_HUMANIGBP1_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10441131 11371618 16085932 18782753 19156129 20092282 21454489 21988832 22167190 23591866 23892082 24145130 24484909 26344197 26496610 27880917 28330616 32296183 9647778 details
PP2AA_HUMAN2ABA_HUMANBioGRID, DIP, HPRD, IntAct, MINT10191253 1328247 18782753 19156129 19915589 20711181 22939629 26344197 26496610 27880917 28330616 32950569 details
PP2AA_HUMANMYC_HUMANBioGRID, MINT17632056 19131971 25438055 details
PP2AA_HUMANKISSR_HUMANBioGRID, MINT18977201 details
PP2AA_HUMANP2R3B_HUMANBioGRID, IntAct10629059 18782753 27880917 details
PP2AA_HUMAN2A5A_HUMANBioGRID, IntAct, MINT18782753 20220139 26344197 26496610 26811472 27880917 28330616 7592815 8703017 details
PP2AA_HUMANCDN2C_HUMANBioGRID, IntAct21988832 details
PP2AA_HUMANMYH9_HUMANBioGRID, IntAct21988832 details
PP2AA_HUMANRAF1_HUMANBioGRID, MINT16041367 16239230 details
PP2AA_HUMANM3K7_HUMANMINT17079228 details
PP2AA_HUMANRBL1_HUMANMINT15467457 details
PP2AA_HUMANRBL2_HUMANBioGRID, MINT12915404 15467457 details
PP2AA_HUMANTF65_HUMANBioGRID, HPRD, MINT11591705 12842894 details
PP2AA_HUMANH2AX_HUMANMINT18758438 details
PP2AA_HUMANMK03_HUMANBioGRID, HPRD, MINT12624094 12840032 details
PP2AA_HUMANMK01_HUMANHPRD, MINT12624094 12840032 details
PP2AA_HUMANRYR1_HUMANMINT18755143 details
PP2AA_HUMANBHE40_HUMANIntAct23555304 details
PP2AA_HUMANCSK2B_HUMANBioGRID, IntAct23555304 details
PP2AA_HUMANRORG_HUMANBioGRID, IntAct23555304 details
PP2AA_HUMANCHK2_HUMANBioGRID, IntAct15380617 16596250 23178491 26083323 details
PP2AA_HUMANLMBL3_HUMANBioGRID, IntAct32296183 details
PP2AA_HUMANCLPP_HUMANBioGRID, IntAct32296183 details
PP2AA_HUMANUBAP2_HUMANBioGRID, IntAct32296183 details
PP2AA_HUMANTRI35_HUMANBioGRID, IntAct32296183 details
PP2AA_HUMANVAC14_HUMANBioGRID, IntAct25416956 32296183 details
PP2AA_HUMANCC036_HUMANIntAct32296183 details
PP2AA_HUMANP2R3A_HUMANBioGRID, IntAct10629059 28514442 details
PP2AA_HUMANAMRA1_HUMANBioGRID, DIP25438055 details
PP2AA_HUMANA4_HUMANIntAct32814053 details
PP2AA_HUMANTLX1_HUMANBioGRID, HPRD9009195 details
PP2AA_HUMANCDK2_HUMANBioGRID10934208 16191191 details
PP2AA_HUMANCDK6_HUMANBioGRID10934208 details
PP2AA_HUMANERF1_HUMANBioGRID, HPRD9003791 details
PP2AA_HUMANCCNG2_HUMANBioGRID, HPRD11956189 details
PP2AA_HUMANBEST1_HUMANBioGRID12058047 details
PP2AA_HUMANKPCD_HUMANBioGRID, HPRD11959144 details
PP2AA_HUMANSGK1_HUMANBioGRID10357815 details
PP2AA_HUMANHDAC7_HUMANBioGRID18339811 details
PP2AA_HUMANTRI18_HUMANBioGRID20092282 22613722 25207814 details
PP2AA_HUMANAAPK1_HUMANBioGRID16306228 22065577 details
PP2AA_HUMANCAV1_HUMANBioGRID14645548 17855368 details
PP2AA_HUMANXRN1_HUMANBioGRID15231747 details
PP2AA_HUMANTTP_HUMANBioGRID17170118 details
PP2AA_HUMANDAPK1_HUMANBioGRID20220139 21172653 details
PP2AA_HUMANPYGM_HUMANBioGRID11983168 details
PP2AA_HUMANKCC1A_HUMANBioGRID24841198 details
PP2AA_HUMANPIM1_HUMANBioGRID17297438 details
PP2AA_HUMANCDC20_HUMANBioGRID26811472 28404789 details
PP2AA_HUMANNOSIP_HUMANBioGRID25546391 details
PP2AA_HUMANCAR11_HUMANBioGRID21157432 details
PP2AA_HUMANPAK1_HUMANBioGRID18586681 details
PP2AA_HUMANAKT3_HUMANBioGRID27563096 details
PP2AA_HUMANCEBPA_HUMANBioGRID15107404 details
PP2AA_HUMANTIF1B_HUMANBioGRID27780869 details
PP2AA_HUMANAKAP6_HUMANBioGRID11590243 details
PP2AA_HUMANTAU_HUMANBioGRID, HPRD12435421 1330687 16262633 7616230 details
PP2AA_HUMANMRCKB_HUMANBioGRID14744259 details
PP2AA_HUMANTIAM1_HUMANBioGRID14744259 details
PP2AA_HUMANBRAF_HUMANBioGRID31015455 details
PP2AA_HUMANYPEL3_HUMANBioGRID32296183 details
PP2AA_HUMANPTEN_HUMANBioGRID31685992 details
PP2AA_HUMANAMOL2_HUMANBioGRID32950569 details
PP2AA_HUMANADCY8_HUMANHPRD16258073 details
PP2AA_HUMANFCAR_HUMANHPRD18768864 details
PP2AA_HUMANIEX1_HUMANMINT16456541 details
PP2AA_HUMANSGO1_HUMANBioGRID, DIP, HPRD, IntAct, UniProt16541025 18716626 19156129 27880917 28330616 details
PP2AA_HUMANSGO2_HUMANBioGRID, HPRD, IntAct, UniProt16541025 26186194 28514442 details
PP2AA_HUMANSIK2_HUMANBioGRID, IntAct16306228 24841198 details
PP2AA_HUMANSTRP1_HUMANBioGRID, DIP, IntAct18782753 19156129 25531779 26496610 28330616 details
PP2AA_HUMAN2A5D_HUMANBioGRID, IntAct18782753 19156129 26344197 26496610 27880917 28330616 8703017 details
PP2AA_HUMANSTRN_HUMANBioGRID, HPRD, IntAct10681496 18782753 19156129 26496610 28330616 details
PP2AA_HUMANSTRN3_HUMANBioGRID, IntAct10681496 18782753 19156129 26496610 28330616 details
PP2AA_HUMAN2A5E_HUMANBioGRID, HPRD, IntAct18782753 19156129 26344197 26496610 27880917 28330616 8703017 details
PP2AA_HUMAN2ABB_HUMANBioGRID, IntAct19156129 23135275 28330616 details
PP2AA_HUMAN2ABG_HUMANBioGRID, IntAct, MINT18782753 19156129 24126060 24841198 26186194 28330616 28514442 details
PP2AA_HUMAN2ABD_HUMANBioGRID, IntAct18782753 19156129 20220139 23135275 26344197 27880917 28330616 28514442 details
PP2AA_HUMANPTPA_HUMANBioGRID, IntAct19156129 19818709 22379092 details
PP2AA_HUMANAXIN1_HUMANbhf-ucl, BioGRID, HPRD, IntAct, MINT17510365 19131971 22682247 9920888 details
PP2AA_HUMANSTRN4_HUMANBioGRID, IntAct18782753 19156129 26496610 28330616 details
PP2AA_HUMANSCHI1_HUMANIntAct20195357 details
PP2AA_HUMANAN32A_HUMANMINT21806989 details
PP2AA_HUMANTIPRL_HUMANBioGRID, IntAct, MINT17384681 22167190 23892082 26344197 details
PP2AA_HUMANIKKB_HUMANBioGRID, MINT16126728 16129692 details
PP2AA_HUMANNEMO_HUMANBioGRID, MINT16126728 16129692 details
PP2AA_HUMANIKKA_HUMANBioGRID, MINT16126728 details
PP2AA_HUMANIF4E_HUMANMINT20927323 details
PP2AA_HUMANMKNK1_HUMANMINT20927323 details
PP2AA_HUMANFGOP2_HUMANBioGRID, IntAct19156129 26496610 28330616 details
PP2AA_HUMANSTRP2_HUMANBioGRID, DIP, IntAct25531779 26496610 details
PP2AA_HUMANINT6_HUMANBioGRID, IntAct20133760 26496610 28330616 details
PP2AA_HUMANIER5_HUMANMINT26496226 details
PP2AA_HUMANINT1_HUMANBioGRID, IntAct20133760 26496610 28330616 details
PP2AA_HUMANPRR14_HUMANBioGRID, IntAct19156129 28514442 details
PP2AA_HUMANLCMT1_HUMANBioGRID, IntAct22167190 26186194 28514442 details
PP2AA_HUMANHUNK_HUMANDIP20133759 details
PP2AA_HUMANCOF1_HUMANDIP20133759 details
PP2AA_HUMANIRF3_HUMANBioGRID, IntAct27956528 32878885 details
PP2AA_HUMANTBCD_HUMANBioGRID12912990 details
PP2AA_HUMANARL2_HUMANBioGRID12912990 details
PP2AA_HUMANKC1A_HUMANBioGRID12062430 details
PP2AA_HUMANPPM1B_HUMANBioGRID10934208 details
PP2AA_HUMANPAXI_HUMANBioGRID, HPRD10675325 details
PP2AA_HUMANSPY2_HUMANBioGRID17255109 17974561 details
PP2AA_HUMANPMS2_HUMANBioGRID17148452 details
PP2AA_HUMANHDAC4_HUMANBioGRID18339811 22466704 31040226 details
PP2AA_HUMANHDAC5_HUMANBioGRID18339811 21081666 details
PP2AA_HUMANPRKDC_HUMANBioGRID20065038 details
PP2AA_HUMANTERF1_HUMANBioGRID20811636 details
PP2AA_HUMANIRAK1_HUMANBioGRID21708940 details
PP2AA_HUMANTBA8_HUMANBioGRID19156129 details
PP2AA_HUMANCE350_HUMANBioGRID19156129 details
PP2AA_HUMANIMB1_HUMANBioGRID19156129 details
PP2AA_HUMANRALA_HUMANBioGRID17540176 details
PP2AA_HUMANPABP1_HUMANBioGRID20544796 details
PP2AA_HUMANM3K3_HUMANBioGRID20448038 details
PP2AA_HUMANTERA_HUMANBioGRID20100830 23108140 details
PP2AA_HUMANAURKB_HUMANBioGRID18477699 details
PP2AA_HUMANKLH15_HUMANBioGRID23135275 details
PP2AA_HUMANCTDP1_HUMANBioGRID12036313 details
PP2AA_HUMANID1_HUMANBioGRID17855368 details
PP2AA_HUMANDPOLA_HUMANBioGRID11259605 details
PP2AA_HUMANSETBP_HUMANBioGRID25306901 details
PP2AA_HUMANEP300_HUMANBioGRID15632055 details
PP2AA_HUMANUNC5B_HUMANBioGRID21172653 details
PP2AA_HUMANRAC1_HUMANBioGRID17245428 details
PP2AA_HUMANUBP7_HUMANBioGRID25695607 details
PP2AA_HUMANCDC27_HUMANBioGRID26811472 details
PP2AA_HUMANBCL10_HUMANBioGRID21157432 details
PP2AA_HUMANANDR_HUMANBioGRID20048054 details
PP2AA_HUMANVHL_HUMANBioGRID27563096 details
PP2AA_HUMANAKT2_HUMANBioGRID27563096 details
PP2AA_HUMANBRCA2_HUMANBioGRID28985013 details
PP2AA_HUMANRMP_HUMANBioGRID27780869 details
PP2AA_HUMANCASP8_HUMANBioGRID25551360 details
PP2AA_HUMANTNF10_HUMANBioGRID25551360 details
PP2AA_HUMANP53_HUMANBioGRID, HPRD12556559 21460856 details
PP2AA_HUMANFBX17_HUMANBioGRID27956528 details
PP2AA_HUMANRACK1_HUMANBioGRID27956528 details
PP2AA_HUMANKPCZ_HUMANBioGRID29491746 details
PP2AA_HUMANBUB1B_HUMANBioGRID28404789 details
PP2AA_HUMANAPC1_HUMANBioGRID28404789 details
PP2AA_HUMANAPC4_HUMANBioGRID28404789 details
PP2AA_HUMANAPC7_HUMANBioGRID28404789 details
PP2AA_HUMANGSK3B_HUMANBioGRID25128526 30711629 details
PP2AA_HUMANSET_HUMANBioGRID, HPRD25128526 9353299 details
PP2AA_HUMANMARCS_HUMANBioGRID30942445 details
PP2AA_HUMANCDC16_HUMANBioGRID31485224 details
PP2AA_HUMANYDJC_HUMANBioGRID31485224 details
PP2AA_HUMANOPSD_HUMANHPRD8617805 details
PP2AA_HUMAN4EBP1_HUMANHPRD16109716 16899564 details
PP2AA_HUMANVDR_HUMANHPRD12036952 details
PP2AA_HUMANGOGA2_HUMANHPRD10769027 details
PP2AA_HUMANPACS1_HUMANHPRD14633983 details
PP2AA_HUMANPYR1_HUMANHPRD4092695 details
PP2AA_HUMANKS6B1_HUMANHPRD10200280 11438723 16109716 16899564 details
PP2AA_HUMANDCE1_HUMANHPRD15147202 details
PP2AA_HUMANPP1A_HUMANHPRD12370081 details
PP2AA_HUMANBMR1B_HUMANHPRD15761153 details
PP2AA_HUMANCCNG1_HUMANHPRD11956189 details
PP2AA_HUMANCXCR2_HUMANHPRD11278485 details
PP2AA_HUMANJAK2_HUMANHPRD11440634 details
PP2AA_HUMANAPC_HUMANHPRD10698523 details
PP2AA_HUMANDVL3_HUMANHPRD10644691 details
PP2AA_HUMANSTA5A_HUMANHPRD11440634 details
PP2AA_HUMANSTA5B_HUMANHPRD11440634 details
PP2AA_HUMANGBRB3_HUMANHPRD14724252 details
PP2AA_HUMANSCN2A_HUMANHPRD8262976 details
PP2AA_HUMANTSC2_HUMANHPRD17163575 details
PP2AA_HUMANRHOB_HUMANHPRD17163575 details
PP2AA_HUMANRRAS_HUMANHPRD17163575 details
PP2AA_HUMANNDKB_HUMANHPRD17163575 details
PP2AA_HUMANNXN_HUMANHPRD16764867 details
PP2AA_HUMANEF2_HUMANHPRD8386634 details