Entity Details

Primary name PKD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP98161
EntryNamePKD1_HUMAN
FullNamePolycystin-1
TaxID9606
Evidenceevidence at protein level
Length4303
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPKD1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001502 cartilage condensation
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001889 liver development
GO:0001892 embryonic placenta development
GO:0002133 polycystin complex
GO:0005262 calcium channel activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005929 cilium
GO:0006611 protein export from nucleus
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007160 cell-matrix adhesion
GO:0007161 calcium-independent cell-matrix adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007507 heart development
GO:0009653 anatomical structure morphogenesis
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0021510 spinal cord development
GO:0021915 neural tube development
GO:0030010 establishment of cell polarity
GO:0030155 regulation of cell adhesion
GO:0030246 carbohydrate binding
GO:0030660 Golgi-associated vesicle membrane
GO:0031514 motile cilium
GO:0032092 positive regulation of protein binding
GO:0034405 response to fluid shear stress
GO:0034703 cation channel complex
GO:0034704 calcium channel complex
GO:0036303 lymph vessel morphogenesis
GO:0042813 Wnt-activated receptor activity
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0043588 skin development
GO:0044325 transmembrane transporter binding
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048565 digestive tract development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048806 genitalia development
GO:0050982 detection of mechanical stimulus
GO:0051216 cartilage development
GO:0051290 protein heterotetramerization
GO:0060170 ciliary membrane
GO:0060236 regulation of mitotic spindle organization
GO:0060271 cilium assembly
GO:0060428 lung epithelium development
GO:0060674 placenta blood vessel development
GO:0061136 regulation of proteasomal protein catabolic process
GO:0070062 extracellular exosome
GO:0070588 calcium ion transmembrane transport
GO:0072164 mesonephric tubule development
GO:0072177 mesonephric duct development
GO:0072205 metanephric collecting duct development
GO:0072218 metanephric ascending thin limb development
GO:0072237 metanephric proximal tubule development
GO:0072287 metanephric distal tubule morphogenesis
GO:0198738 cell-cell signaling by wnt
GO:2000045 regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Endoplasmic reticulum
Golgi apparatus

Domains

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DomainNameCategoryType
IPR000203 GPS motifDomainDomain
IPR000372 Leucine-rich repeat N-terminal domainDomainDomain
IPR000434 Polycystic kidney disease type 1 proteinFamilyFamily
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR000601 PKD domainDomainDomain
IPR001024 PLAT/LH2 domainDomainDomain
IPR001304 C-type lectin-likeDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR002859 PKD/REJ-like domainDomainDomain
IPR002889 Carbohydrate-binding WSCDomainDomain
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR006228 Polycystin cation channelDomainDomain
IPR013122 Polycystin cation channel, PKD1/PKD2DomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014010 REJ domainDomainDomain
IPR016186 C-type lectin-like/link domain superfamilyFamilyHomologous superfamily
IPR016187 C-type lectin foldFamilyHomologous superfamily
IPR022409 PKD/Chitinase domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR035986 PKD domain superfamilyFamilyHomologous superfamily
IPR036392 PLAT/LH2 domain superfamilyFamilyHomologous superfamily
IPR042060 Polycystin-1 like, PLAT/LH2 domainDomainDomain

Diseases

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Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
PKD1_HUMANMCAF1_HUMANHPRD, MINT15231748 details
PKD1_HUMANABL1_HUMANIntAct17474147 details
PKD1_HUMANFYN_HUMANIntAct17474147 details
PKD1_HUMANPKD2_HUMANbhf-ucl, BioGRID, DIP, HPRD, MINT10097141 11901144 19556541 20168298 21126580 21642537 30093605 9192675 details
PKD1_HUMANNPHP1_HUMANBioGRID, MINT20856870 details
PKD1_HUMANLT4R2_HUMANBioGRID, MINT28298427 details
PKD1_HUMANRGS7_HUMANBioGRID, HPRD10339594 details
PKD1_HUMANFINC_HUMANBioGRID, HPRD11752017 details
PKD1_HUMANCO1A1_HUMANBioGRID11752017 details
PKD1_HUMANK1C18_HUMANBioGRID, HPRD11581269 details
PKD1_HUMANCO2A1_HUMANBioGRID, HPRD11406351 details
PKD1_HUMANSIAH1_HUMANBioGRID, HPRD15284290 details
PKD1_HUMANHDAC9_HUMANBioGRID15623513 15738054 details
PKD1_HUMANMARK2_HUMANBioGRID19011111 details
PKD1_HUMANPTPRG_HUMANBioGRID21126580 details
PKD1_HUMANPI51C_HUMANBioGRID27775029 details
PKD1_HUMANNCF1_HUMANBioGRID20856870 details
PKD1_HUMANNCK2_HUMANBioGRID20856870 details
PKD1_HUMANSRC_HUMANBioGRID, HPRD11113628 20856870 details
PKD1_HUMANVIME_HUMANHPRD11581269 details
PKD1_HUMANDESM_HUMANHPRD11581269 details
PKD1_HUMANK2C8_HUMANHPRD11581269 details
PKD1_HUMANPKD1_HUMANBioGRID11901144 details
PKD1_HUMANAT1A1_HUMANBioGRID11901144 details
PKD1_HUMANJADE1_HUMANBioGRID23001567 details
PKD1_HUMANFAK1_HUMANBioGRID11113628 27775029 details
PKD1_HUMANCTNB1_HUMANBioGRID, HPRD11113628 11274246 details
PKD1_HUMANGAN_HUMANBioGRID26460568 details
PKD1_HUMANAKT1_HUMANBioGRID24462114 details
PKD1_HUMANPTPRS_HUMANBioGRID21126580 details
PKD1_HUMANCADH1_HUMANBioGRID21126580 details
PKD1_HUMANPLAK_HUMANHPRD11274246 details
PKD1_HUMANTLN1_HUMANHPRD11113628 details
PKD1_HUMANVINC_HUMANHPRD11113628 details
PKD1_HUMANACTN1_HUMANHPRD11113628 details
PKD1_HUMANPAXI_HUMANHPRD11113628 details
PKD1_HUMANBCAR1_HUMANHPRD11113628 details
PKD1_HUMANCTNA1_HUMANHPRD11274246 details
PKD1_HUMANJAK2_HUMANHPRD12007403 details