Entity Details

Primary name GNA12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ03113
EntryNameGNA12_HUMAN
FullNameGuanine nucleotide-binding protein subunit alpha-12
TaxID9606
Evidenceevidence at protein level
Length381
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesGNA12

GO terms

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GOName
GO:0001664 G protein-coupled receptor binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007266 Rho protein signal transduction
GO:0007596 blood coagulation
GO:0010762 regulation of fibroblast migration
GO:0016328 lateral plasma membrane
GO:0030168 platelet activation
GO:0031526 brush border membrane
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0031752 D5 dopamine receptor binding
GO:0032006 regulation of TOR signaling
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042493 response to drug
GO:0046872 metal ion binding
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1904753 negative regulation of vascular associated smooth muscle cell migration

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Lateral cell membrane

Domains

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DomainNameCategoryType
IPR000469 G-protein alpha subunit, group 12/13FamilyFamily
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunitFamilyFamily
IPR011025 G protein alpha subunit, helical insertionFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
GNA12_HUMANARHG1_HUMANBioGRID, MINT14634662 20300064 details
GNA12_HUMANIL3RA_HUMANBioGRID, IntAct21988832 details
GNA12_HUMAN2AAA_HUMANHPRD, MINT15525651 details
GNA12_HUMANAGTR1_HUMANBioGRID, MINT28298427 details
GNA12_HUMANCAD15_HUMANBioGRID, HPRD11136230 details
GNA12_HUMANCADH1_HUMANBioGRID11136230 details
GNA12_HUMANCADH2_HUMANBioGRID, HPRD11136230 details
GNA12_HUMANPPP5_HUMANBioGRID, HPRD12176367 details
GNA12_HUMANS1PR4_HUMANBioGRID, HPRD12761884 details
GNA12_HUMANKPCB_HUMANBioGRID8824244 details
GNA12_HUMANKPCE_HUMANBioGRID8824244 details
GNA12_HUMANKPCD_HUMANBioGRID8824244 details
GNA12_HUMANHS90A_HUMANBioGRID, HPRD11598136 12117999 details
GNA12_HUMANA4_HUMANBioGRID21832049 details
GNA12_HUMANARAF_HUMANBioGRID24114843 details
GNA12_HUMANSNAA_HUMANHPRD15980433 details
GNA12_HUMANH15_HUMANIntAct30021884 details
GNA12_HUMANAKP13_HUMANBioGRID, HPRD11546812 14636890 details
GNA12_HUMANDRD5_HUMANBioGRID, HPRD12623966 details
GNA12_HUMANARHGC_HUMANBioGRID, HPRD11094164 12515866 details
GNA12_HUMANTEC_HUMANBioGRID, HPRD12515866 details
GNA12_HUMANPAR1_HUMANBioGRID, HPRD8290554 details
GNA12_HUMANTA2R_HUMANBioGRID, HPRD8290554 details
GNA12_HUMANARHGB_HUMANBioGRID, HPRD10026210 details
GNA12_HUMANM3K5_HUMANBioGRID17595347 details
GNA12_HUMANARG28_HUMANBioGRID17595347 details
GNA12_HUMANGBB3_HUMANBioGRID22940628 details
GNA12_HUMANKPCA_HUMANHPRD8647866 details
GNA12_HUMANBTK_HUMANHPRD9796816 details
GNA12_HUMANRASA2_HUMANHPRD9796816 details
GNA12_HUMANTSHR_HUMANHPRD8552586 details
GNA12_HUMANGNA12_HUMANHPRD9796816 details
GNA12_HUMANGNA13_HUMANHPRD10026210 details
GNA12_HUMANS1PR5_HUMANHPRD11069896 details
GNA12_HUMANACTB_HUMANHPRD10787407 details
GNA12_HUMANGBB1_HUMANHPRD7829508 details