Entity Details

Primary name KPCT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ04759
EntryNameKPCT_HUMAN
FullNameProtein kinase C theta type
TaxID9606
Evidenceevidence at protein level
Length706
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesPRKCQ

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001558 regulation of cell growth
GO:0001772 immunological synapse
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0006509 membrane protein ectodomain proteolysis
GO:0006954 inflammatory response
GO:0007411 axon guidance
GO:0016235 aggresome
GO:0018105 peptidyl-serine phosphorylation
GO:0030168 platelet activation
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0032740 positive regulation of interleukin-17 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032753 positive regulation of interleukin-4 production
GO:0034451 centriolar satellite
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0045652 regulation of megakaryocyte differentiation
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046872 metal ion binding
GO:0050852 T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051973 positive regulation of telomerase activity
GO:0060326 cell chemotaxis
GO:0070233 negative regulation of T cell apoptotic process
GO:0090330 regulation of platelet aggregation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904355 positive regulation of telomere capping
GO:2000318 positive regulation of T-helper 17 type immune response
GO:2000570 positive regulation of T-helper 2 cell activation

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014376 Protein kinase C, delta/epsilon/eta/theta typesFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR027264 Protein kinase C, thetaFamilyFamily
IPR034668 Novel protein kinase C theta, catalytic domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00675 TamoxifenDrugbanksmall molecule
DB02010 StaurosporineDrugbanksmall molecule
DB02482 PhosphonothreonineDrugbanksmall molecule
DB04522 DexfosfoserineDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
KPCT_HUMANGLRX3_HUMANBioGRID, HPRD, IntAct10636891 details
KPCT_HUMANFYN_HUMANBioGRID, HPRD, IntAct10383400 details
KPCT_HUMANKPCZ_HUMANIntAct17588663 details
KPCT_HUMANLCK_HUMANBioGRID, HPRD, InnateDB10383400 10652356 21964608 details
KPCT_HUMANM4K3_HUMANInnateDB21983831 details
KPCT_HUMANHSF1_HUMANIntAct23352416 details
KPCT_HUMANCAR11_HUMANBioGRID, HPRD, IntAct14673152 16356855 19706536 20164171 21157432 22528498 details
KPCT_HUMANTAL1_HUMANBioGRID10383400 details
KPCT_HUMANAKT1_HUMANBioGRID, HPRD11410591 details
KPCT_HUMAN1433T_HUMANBioGRID8816492 details
KPCT_HUMANCBL_HUMANBioGRID10358153 details
KPCT_HUMANLYAM1_HUMANBioGRID15192100 details
KPCT_HUMANGRP3_HUMANBioGRID, HPRD12730099 details
KPCT_HUMANKPCT_HUMANBioGRID, HPRD11410591 16252004 19706536 details
KPCT_HUMANBTK_HUMANHPRD, IntAct11788586 details
KPCT_HUMANMALT1_HUMANBioGRID, MINT17363905 details
KPCT_HUMANMARK3_HUMANHPRD, MINT17363905 8816492 details
KPCT_HUMANBCL10_HUMANBioGRID, MINT17363905 20164171 details
KPCT_HUMANHS90B_HUMANIntAct22939624 details
KPCT_HUMANVAV_HUMANBioGRID, HPRD10725744 details
KPCT_HUMANIKKB_HUMANBioGRID, HPRD11120819 15802604 17363905 20164171 details
KPCT_HUMAN1433G_HUMANBioGRID, HPRD10433554 details
KPCT_HUMANPDPK1_HUMANBioGRID15802604 details
KPCT_HUMANIKKA_HUMANBioGRID, HPRD15802604 17363905 20164171 details
KPCT_HUMANNEMO_HUMANBioGRID, HPRD15802604 details
KPCT_HUMANJUND_HUMANBioGRID16264271 details
KPCT_HUMANM3K7_HUMANBioGRID17363905 20164171 details
KPCT_HUMANFYB1_HUMANBioGRID20164171 details
KPCT_HUMANKCNA5_HUMANBioGRID22547057 details
KPCT_HUMANALK_HUMANBioGRID14968112 details
KPCT_HUMANLYN_HUMANHPRD11358993 details
KPCT_HUMANMOES_HUMANHPRD9516463 9856983 details
KPCT_HUMANCASP3_HUMANHPRD9252332 details
KPCT_HUMANWIPF1_HUMANHPRD12504004 details
KPCT_HUMANCISH_HUMANHPRD12618484 details
KPCT_HUMANSTK39_HUMANHPRD10980603 details
KPCT_HUMANHABP4_HUMANHPRD14699138 details
KPCT_HUMANGRM5_HUMANHPRD15894802 details
KPCT_HUMANIRS1_HUMANHPRD15364919 details
KPCT_HUMANICAM3_HUMANHPRD9268366 details