Entity Details

Primary name PUR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ06203
EntryNamePUR1_HUMAN
FullNameAmidophosphoribosyltransferase
TaxID9606
Evidenceevidence at protein level
Length517
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesPPAT

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001822 kidney development
GO:0004044 amidophosphoribosyltransferase activity
GO:0005829 cytosol
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0006543 glutamine catabolic process
GO:0007595 lactation
GO:0009113 purine nucleobase biosynthetic process
GO:0009116 nucleoside metabolic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0031100 animal organ regeneration
GO:0032869 cellular response to insulin stimulus
GO:0035690 cellular response to drug
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0060135 maternal process involved in female pregnancy

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000836 Phosphoribosyltransferase domainDomainDomain
IPR005854 AmidophosphoribosyltransferaseFamilyFamily
IPR017932 Glutamine amidotransferase type 2 domainDomainDomain
IPR029055 Nucleophile aminohydrolases, N-terminalFamilyHomologous superfamily
IPR029057 Phosphoribosyltransferase-likeFamilyHomologous superfamily
IPR035584 Amidophosphoribosyltransferase, N-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00130 L-GlutamineDrugbanksmall molecule
DB00544 FluorouracilDrugbanksmall molecule
DB01033 MercaptopurineDrugbanksmall molecule
DB01254 DasatinibDrugbanksmall molecule

Interactions

4 interactions