Entity Details

Primary name SOS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ07889
EntryNameSOS1_HUMAN
FullNameSon of sevenless homolog 1
TaxID9606
Evidenceevidence at protein level
Length1333
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesSOS1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001782 B cell homeostasis
GO:0001942 hair follicle development
GO:0003209 cardiac atrium morphogenesis
GO:0003344 pericardium morphogenesis
GO:0003677 DNA binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007296 vitellogenesis
GO:0007411 axon guidance
GO:0008286 insulin receptor signaling pathway
GO:0014069 postsynaptic density
GO:0017124 SH3 domain binding
GO:0019221 cytokine-mediated signaling pathway
GO:0033081 regulation of T cell differentiation in thymus
GO:0035264 multicellular organism growth
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038128 ERBB2 signaling pathway
GO:0042129 regulation of T cell proliferation
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0046982 protein heterodimerization activity
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0050900 leukocyte migration
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0060021 roof of mouth development
GO:0061029 eyelid development in camera-type eye
GO:0061384 heart trabecula morphogenesis
GO:1904693 midbrain morphogenesis
GO:2000973 regulation of pro-B cell differentiation

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminalDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR007125 Histone H2A/H2B/H3DomainDomain
IPR008937 Ras-like guanine nucleotide exchange factorFamilyFamily
IPR009072 Histone-foldFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR019804 Ras guanine-nucleotide exchange factor, conserved siteSiteConserved site
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

74 interactions

InteractorPartnerSourcesPublicationsLink
SOS1_HUMANABI1_HUMANBioGRID, HPRD, MINT10499589 details
SOS1_HUMANHCK_HUMANHPRD, IntAct, MINT12029088 17141806 23397142 details
SOS1_HUMANITSN1_HUMANBioGRID, HPRD, IntAct, MINT10716926 15824104 18539136 20936779 32203420 details
SOS1_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10025673 10207103 10319320 10477741 10570290 10716926 11726515 11960376 11964172 11997436 12577067 14679214 15192046 16520382 16893902 16906159 17474147 19323566 19380743 20473329 21706016 21988832 28166272 28514442 31980649 32062451 32203420 7510700 7514169 7516467 7527391 7559490 7629138 7629168 7642581 7664271 7773779 8112292 8188688 8479541 8493579 8626525 8695800 8810325 8816480 8943292 9009162 9344843 9447984 9478994 9569023 9716598 9797459 9872323 details
SOS1_HUMANNCK1_HUMANBioGRID, HPRD, IntAct10026169 10206341 17474147 32203420 7862111 8810325 details
SOS1_HUMANRASH_HUMANBioGRID, DIP, HPRD, IntAct, MINT11560935 12628188 15507210 17084389 18454158 19141281 20133692 26721396 9447984 9690470 details
SOS1_HUMAN3BP5_HUMANBioGRID, IntAct17043677 31413325 details
SOS1_HUMANPLCG1_HUMANBioGRID, HPRD, IntAct, MINT10913276 10940929 17474147 9020117 details
SOS1_HUMANCRK_HUMANBioGRID, HPRD, IntAct17474147 19380743 25241761 31980649 32203420 8810325 8943292 details
SOS1_HUMANSRC_HUMANIntAct17474147 details
SOS1_HUMANFYN_HUMANBioGRID, HPRD, IntAct17474147 9856337 details
SOS1_HUMANP85A_HUMANBioGRID, IntAct17474147 25241761 details
SOS1_HUMANNEBU_HUMANMINT12482578 details
SOS1_HUMANSPD2A_HUMANMINT19464300 details
SOS1_HUMANVIGLN_HUMANBioGRID, IntAct20936779 details
SOS1_HUMANITSN2_HUMANBioGRID, IntAct20936779 22558309 details
SOS1_HUMANSPTN1_HUMANBioGRID, IntAct20936779 details
SOS1_HUMANNOSTN_HUMANMINT22751148 details
SOS1_HUMANUBS3A_HUMANBioGRID, IntAct32296183 details
SOS1_HUMANEGFR_HUMANBioGRID, DIP, HPRD, IntAct10675333 18271526 19289468 19531499 20473329 23956138 24797263 25754235 26005835 31959764 7510700 8621459 9447973 details
SOS1_HUMANCSN3_HUMANBioGRID, MINT30631038 details
SOS1_HUMANBIN1_HUMANBioGRID, HPRD, IntAct32203420 9182529 details
SOS1_HUMANANXA2_HUMANBioGRID7510700 details
SOS1_HUMANTNIK_HUMANBioGRID17043677 details
SOS1_HUMANLCK_HUMANBioGRID16274251 details
SOS1_HUMANMK03_HUMANBioGRID8621459 details
SOS1_HUMANSHPS1_HUMANBioGRID19299420 details
SOS1_HUMANABI3_HUMANHPRD11956071 details
SOS1_HUMANPACN3_HUMANHPRD, IntAct14679214 details
SOS1_HUMANSNX9_HUMANHPRD, IntAct14679214 details
SOS1_HUMANCD2AP_HUMANBioGRID, HPRD, IntAct14679214 32203420 details
SOS1_HUMANSNX18_HUMANHPRD, IntAct14679214 details
SOS1_HUMANSHC1_HUMANBioGRID, HPRD, IntAct, MINT10025673 10570290 10675333 10783152 16371368 19380743 7520523 7559490 8235613 8621459 8626525 8631299 8950973 9344843 9544989 details
SOS1_HUMANEPS8_HUMANBioGRID, HPRD, MINT10499589 14565974 16520382 27629044 details
SOS1_HUMANFGFR1_HUMANBioGRID, HPRD, IntAct25241761 9480847 details
SOS1_HUMANCRKL_HUMANBioGRID, HPRD, IntAct23397142 26496610 32203420 9162067 details
SOS1_HUMANGAB1_HUMANHPRD, IntAct11707404 23397142 details
SOS1_HUMANPACN1_HUMANHPRD, IntAct11352907 31413325 details
SOS1_HUMANPTN11_HUMANBioGRID, HPRD, IntAct16371368 20473329 9344843 9632781 details
SOS1_HUMANES8L1_HUMANBioGRID, HPRD14565974 details
SOS1_HUMANES8L2_HUMANBioGRID, HPRD14565974 details
SOS1_HUMANSH3K1_HUMANBioGRID, HPRD11071869 details
SOS1_HUMANBCR_HUMANBioGRID7529874 8112292 details
SOS1_HUMANABL1_HUMANBioGRID8112292 details
SOS1_HUMANMERL_HUMANBioGRID10675333 details
SOS1_HUMANFRS2_HUMANBioGRID, HPRD10783152 11997436 16893902 9182757 9797459 details
SOS1_HUMANMUC1_HUMANBioGRID, HPRD11278868 7664271 details
SOS1_HUMANPTN6_HUMANBioGRID, HPRD8632004 details
SOS1_HUMANGRAP_HUMANBioGRID, HPRD8647802 details
SOS1_HUMANMET_HUMANBioGRID9660480 details
SOS1_HUMANRIT2_HUMANBioGRID, HPRD12099688 details
SOS1_HUMANNCK2_HUMANBioGRID, HPRD10026169 details
SOS1_HUMANSRRM1_HUMANBioGRID16159877 details
SOS1_HUMANCSF1R_HUMANBioGRID, HPRD10025673 7520523 details
SOS1_HUMANCBL_HUMANBioGRID10025673 details
SOS1_HUMANSRBS1_HUMANBioGRID17548467 details
SOS1_HUMANTNR1A_HUMANBioGRID19289468 details
SOS1_HUMANLRRK1_HUMANBioGRID20697350 details
SOS1_HUMANLAT_HUMANBioGRID16906159 details
SOS1_HUMANRAC1_HUMANBioGRID27629044 details
SOS1_HUMANCSN7A_HUMANBioGRID30631038 details
SOS1_HUMANRRAS_HUMANHPRD11560935 details
SOS1_HUMANZAP70_HUMANHPRD7629168 details
SOS1_HUMANERBB3_HUMANHPRD11173924 details
SOS1_HUMANVATE1_HUMANHPRD11560919 details
SOS1_HUMANMK01_HUMANHPRD8816480 details
SOS1_HUMANSOS1_HUMANHPRD14656442 details
SOS1_HUMANCAV1_HUMANHPRD15976327 details
SOS1_HUMANCD19_HUMANHPRD10706702 details
SOS1_HUMANESR1_HUMANHPRD15173068 details
SOS1_HUMANP85B_HUMANHPRD9651378 details
SOS1_HUMANRANB9_HUMANHPRD12147692 details
SOS1_HUMANNTAL_HUMANHPRD12486104 details
SOS1_HUMANERBB2_HUMANHPRD11173924 details