Entity Details

Primary name DMP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13316
EntryNameDMP1_HUMAN
FullNameDentin matrix acidic phosphoprotein 1
TaxID9606
Evidenceevidence at protein level
Length513
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesDMP1

GO terms

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GOName
GO:0001503 ossification
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005788 endoplasmic reticulum lumen
GO:0010811 positive regulation of cell-substrate adhesion
GO:0030198 extracellular matrix organization
GO:0031012 extracellular matrix
GO:0031214 biomineral tissue development
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0050840 extracellular matrix binding
GO:0070173 regulation of enamel mineralization

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR009889 Dentin matrix 1FamilyFamily

Diseases

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Disease IDSourceNameDescription
241520 OMIMHypophosphatemic rickets, autosomal recessive, 1 (ARHR1)A hereditary form of hypophosphatemic rickets, a disorder of proximal renal tubule function that causes phosphate loss, hypophosphatemia and skeletal deformities, including rickets and osteomalacia unresponsive to vitamin D. Symptoms are bone pain, fractures and growth abnormalities. The disease is caused by variants affecting the gene represented in this entry.

Interactions

3 interactions