Entity Details

Primary name I10R1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13651
EntryNameI10R1_HUMAN
FullNameInterleukin-10 receptor subunit alpha
TaxID9606
Evidenceevidence at protein level
Length578
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesIL10RA

GO terms

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GOName
GO:0004896 cytokine receptor activity
GO:0004920 interleukin-10 receptor activity
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010507 negative regulation of autophagy
GO:0016021 integral component of membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019969 interleukin-10 binding
GO:0032496 response to lipopolysaccharide
GO:0038023 signaling receptor activity
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0050807 regulation of synapse organization
GO:0070086 ubiquitin-dependent endocytosis

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613148 OMIMInflammatory bowel disease 28 (IBD28)A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. The disease is caused by variants affecting the gene represented in this entry.

Interactions

27 interactions

InteractorPartnerSourcesPublicationsLink
I10R1_HUMANIL10_HUMANBioGRID, DIP, HPRD, IntAct, MINT10231374 11485736 11717514 12513909 15837194 20462497 7759550 8248239 8897595 details
I10R1_HUMANHACD2_HUMANIntAct32296183 details
I10R1_HUMANZNT2_HUMANIntAct32296183 details
I10R1_HUMANGLPA_HUMANIntAct32296183 details
I10R1_HUMANTMM60_HUMANIntAct32296183 details
I10R1_HUMANCD302_HUMANIntAct32296183 details
I10R1_HUMANVATL_HUMANIntAct32296183 details
I10R1_HUMANVAMP5_HUMANIntAct32296183 details
I10R1_HUMANNIPA4_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANS38A7_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANSELK_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANTMUB2_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANHACD1_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANRUSF1_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANCKLF3_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANPLPP6_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANCDS2_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANMAL_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANSMCO4_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANS7A14_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANS66A2_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANFBW1A_HUMANBioGRID, IntAct, UniProt22087322 32296183 details
I10R1_HUMANYIPF6_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANTM242_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANC1QL4_HUMANBioGRID, IntAct32296183 details
I10R1_HUMANJAK1_HUMANBioGRID, HPRD10433356 12133952 12374810 details
I10R1_HUMANI10R2_HUMANBioGRID, HPRD9312047 details