Entity Details

Primary name CAC1C_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13936
EntryNameCAC1C_HUMAN
FullNameVoltage-dependent L-type calcium channel subunit alpha-1C
TaxID9606
Evidenceevidence at protein level
Length2221
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesCACNA1C

GO terms

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GOName
GO:0002520 immune system development
GO:0005245 voltage-gated calcium channel activity
GO:0005516 calmodulin binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0006816 calcium ion transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007507 heart development
GO:0008331 high voltage-gated calcium channel activity
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014069 postsynaptic density
GO:0016021 integral component of membrane
GO:0016032 viral process
GO:0030018 Z disc
GO:0030425 dendrite
GO:0035115 embryonic forelimb morphogenesis
GO:0035585 calcium-mediated signaling using extracellular calcium source
GO:0043010 camera-type eye development
GO:0043204 perikaryon
GO:0045762 positive regulation of adenylate cyclase activity
GO:0046872 metal ion binding
GO:0050796 regulation of insulin secretion
GO:0051393 alpha-actinin binding
GO:0060402 calcium ion transport into cytosol
GO:0061337 cardiac conduction
GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086045 membrane depolarization during AV node cell action potential
GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:0086091 regulation of heart rate by cardiac conduction
GO:0098839 postsynaptic density membrane
GO:0098911 regulation of ventricular cardiac muscle cell action potential
GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential
GO:1990454 L-type voltage-gated calcium channel complex

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Perikaryon

Domains

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DomainNameCategoryType
IPR002077 Voltage-dependent calcium channel, alpha-1 subunitFamilyFamily
IPR005446 Voltage-dependent calcium channel, L-type, alpha-1 subunitFamilyFamily
IPR005451 Voltage-dependent calcium channel, L-type, alpha-1C subunitFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domainDomainDomain
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily
IPR031649 Voltage-dependent L-type calcium channel, IQ-associated domainDomainDomain
IPR031688 Voltage-gated calcium channel subunit alpha, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00153 ErgocalciferolDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00243 RanolazineDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00270 IsradipineDrugbanksmall molecule
DB00273 TopiramateDrugbanksmall molecule
DB00308 IbutilideDrugbanksmall molecule
DB00343 DiltiazemDrugbanksmall molecule
DB00381 AmlodipineDrugbanksmall molecule
DB00393 NimodipineDrugbanksmall molecule
DB00401 NisoldipineDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB00653 Magnesium sulfateDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00825 LevomentholDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB01023 FelodipineDrugbanksmall molecule
DB01054 NitrendipineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01373 CalciumDrugbanksmall molecule
DB01388 MibefradilDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB04920 ClevidipineDrugbanksmall molecule
DB06712 NilvadipineDrugbanksmall molecule
DB06751 DrotaverineDrugbanksmall molecule
DB09089 TrimebutineDrugbanksmall molecule
DB09227 BarnidipineDrugbanksmall molecule
DB09229 AranidipineDrugbanksmall molecule
DB09231 BenidipineDrugbanksmall molecule
DB09232 CilnidipineDrugbanksmall molecule
DB09235 EfonidipineDrugbanksmall molecule
DB09236 LacidipineDrugbanksmall molecule
DB09237 LevamlodipineDrugbanksmall molecule
DB09238 ManidipineDrugbanksmall molecule
DB11093 Calcium citrateDrugbanksmall molecule
DB11148 ButambenDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB11633 IsavuconazoleDrugbanksmall molecule
DB12278 PropiverineDrugbanksmall molecule
DB13746 BioallethrinDrugbanksmall molecule
DB13961 Fish oilDrugbankbiotech
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule

Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
CAC1C_HUMANCABP1_HUMANBioGRID, DIP, HPRD, IntAct15140941 21134641 details
CAC1C_HUMANCALM2_HUMANBioGRID, DIP, IntAct, MINT15140941 16299511 16338416 19279214 20953164 details
CAC1C_HUMANPHS_HUMANBioGRID11461190 details
CAC1C_HUMANRYR2_HUMANBioGRID, HPRD11576544 details
CAC1C_HUMANSORCN_HUMANBioGRID, HPRD9668070 details
CAC1C_HUMANHDAC4_HUMANBioGRID21464227 details
CAC1C_HUMANCSN5_HUMANBioGRID16483597 details
CAC1C_HUMANKCNE2_HUMANBioGRID24681347 details
CAC1C_HUMANGBB1_HUMANHPRD15953418 details
CAC1C_HUMANCACB2_HUMANDIP18535142 details
CAC1C_HUMANCACB3_HUMANBioGRID, DIP, HPRD15170217 18535142 details
CAC1C_HUMANCACB1_HUMANDIP18535142 details
CAC1C_HUMANBIN1_HUMANDIP20169111 details
CAC1C_HUMANPICK1_HUMANMINT21653829 details
CAC1C_HUMANACTN1_HUMANMINT21653829 details
CAC1C_HUMANCR032_HUMANMINT21653829 details
CAC1C_HUMANBASI_HUMANMINT21653829 details
CAC1C_HUMANANR35_HUMANMINT21653829 details
CAC1C_HUMANACTN2_HUMANMINT21653829 details
CAC1C_HUMANDNJA3_HUMANMINT21653829 details
CAC1C_HUMANFHL2_HUMANMINT21653829 details
CAC1C_HUMANFBLN3_HUMANMINT21653829 details
CAC1C_HUMANTERA_HUMANBioGRID, MINT21186355 21653829 details
CAC1C_HUMANTNIP2_HUMANMINT21653829 details
CAC1C_HUMANSRRT_HUMANMINT21653829 details
CAC1C_HUMANRIC3_HUMANMINT21653829 details
CAC1C_HUMANNU133_HUMANMINT21653829 details
CAC1C_HUMANIFT88_HUMANMINT21653829 details
CAC1C_HUMANDERL1_HUMANBioGRID21186355 details
CAC1C_HUMANTRI13_HUMANBioGRID21186355 details
CAC1C_HUMANCALM1_HUMANBioGRID16338416 details
CAC1C_HUMANCALM3_HUMANBioGRID16338416 details
CAC1C_HUMANMDM2_HUMANBioGRID31012223 details
CAC1C_HUMANLITAF_HUMANBioGRID31462068 details
CAC1C_HUMANKCNB1_HUMANBioGRID31663850 details
CAC1C_HUMANKCNB2_HUMANBioGRID31663850 details
CAC1C_HUMANKAPCA_HUMANHPRD8612821 8664319 9247274 details
CAC1C_HUMANPPM1A_HUMANHPRD15728831 details
CAC1C_HUMANRIMS1_HUMANHPRD11438519 details