Entity Details

Primary name ERN1
Entity type gene
Source Source Link

Details

PrimaryID2081
RefseqGene
SymbolERN1
Nameendoplasmic reticulum to nucleus signaling 1
Chromosome17
Location17q23.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-06
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsERN1_HUMAN

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001935 endothelial cell proliferation
GO:0004521 endoribonuclease activity
GO:0004674 protein serine/threonine kinase activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005524 ATP binding
GO:0005637 nuclear inner membrane
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006379 mRNA cleavage
GO:0006402 mRNA catabolic process
GO:0006468 protein phosphorylation
GO:0007257 obsolete activation of JUN kinase activity
GO:0016241 regulation of macroautophagy
GO:0019899 enzyme binding
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030544 Hsp70 protein binding
GO:0033120 positive regulation of RNA splicing
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036289 peptidyl-serine autophosphorylation
GO:0036498 IRE1-mediated unfolded protein response
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043531 ADP binding
GO:0046777 protein autophosphorylation
GO:0051082 unfolded protein binding
GO:0051879 Hsp90 protein binding
GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070301 cellular response to hydrogen peroxide
GO:0071333 cellular response to glucose stimulus
GO:0098787 mRNA cleavage involved in mRNA processing
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901142 insulin metabolic process
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1990332 Ire1 complex
GO:1990579 peptidyl-serine trans-autophosphorylation
GO:1990597 AIP1-IRE1 complex
GO:1990604 IRE1-TRAF2-ASK1 complex
GO:1990630 IRE1-RACK1-PP2A complex

Diseases

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Interactions

76 interactions

InteractorPartnerSourcesPublicationsLink
ERN1ERN1BioGRID, DIP, HPRD, IntAct, MINT12637535 16973740 20798350 21317875 details
ERN1BAXHPRD, IntAct16645094 details
ERN1TAOK3BioGRID, HPRD, IntAct11278723 details
ERN1SRPK2BioGRID, IntAct23602568 details
ERN1HSPA5BioGRID, DIP, HPRD, IntAct12637535 21118962 26551274 27238082 32149426 details
ERN1ZNF829IntAct32814053 details
ERN1PELI3IntAct32814053 details
ERN1SPATS1IntAct32814053 details
ERN1ADALIntAct32814053 details
ERN1AK8IntAct32814053 details
ERN1ZNF341IntAct32814053 details
ERN1TMTC1IntAct32814053 details
ERN1PLEKHS1IntAct32814053 details
ERN1OTUD7BIntAct32814053 details
ERN1CBWD1IntAct32814053 details
ERN1ASIC4IntAct32814053 details
ERN1WBP1LIntAct32814053 details
ERN1ARL6IP4IntAct32814053 details
ERN1CD209IntAct32814053 details
ERN1PLEKHG4IntAct32814053 details
ERN1POLA2IntAct32814053 details
ERN1SLC7A8IntAct32814053 details
ERN1LARP4BIntAct32814053 details
ERN1BAHD1IntAct32814053 details
ERN1SOCS6IntAct32814053 details
ERN1DNAJA3IntAct32814053 details
ERN1ASH2LIntAct32814053 details
ERN1DPF1IntAct32814053 details
ERN1UBE2AIntAct32814053 details
ERN1PER1IntAct32814053 details
ERN1GTF2A1IntAct32814053 details
ERN1GABPB1IntAct32814053 details
ERN1CDKN1AIntAct32814053 details
ERN1INCA1IntAct32814053 details
ERN1HSP90AA1BioGRID, HPRD12446770 details
ERN1COPS5BioGRID, HPRD15234121 17951406 details
ERN1USP14BioGRID19135427 24951540 details
ERN1STUB1BioGRID25225294 details
ERN1NMIBioGRID24936061 details
ERN1MARCHF5BioGRID31368599 details
ERN1P4HBBioGRID32149426 details
ERN1SYVN1BioGRID, DIP, HPRD, MINT18369366 19135427 26254280 26551274 details
ERN1UBCMINT18369366 details
ERN1TRAF2BioGRID, HPRD, IntAct10650002 11278723 12843613 25225294 25241761 25797626 details
ERN1MAP3K5BioGRID, HPRD, IntAct12050113 25241761 25797626 details
ERN1YIPF5HPIDb25742138 details
ERN1OS9DIP26551274 details
ERN1SEL1LBioGRID, DIP19135427 26551274 details
ERN1PSEN1BioGRID, HPRD10587643 details
ERN1DERL1BioGRID19135427 details
ERN1DERL3BioGRID19135427 details
ERN1TRAF6BioGRID23942232 details
ERN1RNF13BioGRID23378536 details
ERN1TP53BioGRID26254280 details
ERN1RIPK1BioGRID25476903 details
ERN1SEC61BBioGRID28504640 details
ERN1SEC61A1BioGRID28504640 details
ERN1SEC63BioGRID28504640 details
ERN1BCL2L11BioGRID31368599 details
ERN1PDIA6BioGRID32149426 details
ERN1BAK1HPRD16645094 details
ERN1TNFRSF1AHPRD16680093 details
ERN1SEC24CHPIDb25742138 details
ERN1SEC24AHPIDb25742138 details
ERN1SEC24DHPIDb25742138 details
ERN1SEC24BHPIDb25742138 details
ERN1SCGB2A2BioGRID, IntAct28514442 details
ERN1NTAQ1BioGRID, IntAct28514442 details
ERN1ZNRF4BioGRID, IntAct28514442 details
ERN1LYPD4BioGRID, IntAct28514442 details
ERN1OTUB1BioGRID25225294 details
ERN1UCHL1BioGRID25225294 details
ERN1FBXO11BioGRID25225294 details
ERN1HSPA1ADIP20625543 details
ERN1HSPA1BDIP20625543 details
ERN1VIRMABioGRID29507755 details