Entity Details

Primary name SPEN
Entity type gene
Source Source Link

Details

PrimaryID23013
RefseqGeneNG_050663
SymbolSPEN
Namespen family transcriptional repressor
Chromosome1
Location1p36.21-p36.13
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-11-30
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsMINT_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000398 mRNA splicing, via spliceosome
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0007219 Notch signaling pathway
GO:0016032 viral process
GO:0017053 transcription repressor complex
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050769 positive regulation of neurogenesis
GO:0070062 extracellular exosome

Diseases

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Interactions

88 interactions

InteractorPartnerSourcesPublicationsLink
SPENATXN1BioGRID, HPRD, IntAct16713569 details
SPENCRKIntAct17474147 details
SPENGRB2IntAct17474147 details
SPENNCK1IntAct17474147 details
SPENPIK3R1IntAct17474147 details
SPENPLCG1IntAct17474147 details
SPENRBPJBioGRID, HPRD, IntAct, MINT12374742 18332109 21102556 25609649 26186194 28514442 details
SPENRIDABioGRID, IntAct21988832 details
SPENSERTAD1BioGRID, IntAct21988832 details
SPENNCOR2BioGRID, DIP, HPRD11331609 15604093 24268649 details
SPENHDAC1BioGRID, HPRD11331609 details
SPENSRA1BioGRID11331609 details
SPENNCOR1BioGRID, HPRD11331609 12897056 details
SPENCTBP1BioGRID16287852 details
SPENRBBP8BioGRID16287852 details
SPENRUNX1T1BioGRID18332109 details
SPENRUNX1BioGRID18332109 details
SPENUBE2E2BioGRID16583136 details
SPENUBE2L6BioGRID, HPRD16583136 details
SPENSRPK2BioGRID26167880 details
SPENCLK1BioGRID26167880 details
SPENPPARDBioGRID, HPRD11867749 details
SPENNR3C1BioGRID28611094 31182584 details
SPENNCBP2BioGRID29395067 details
SPENSUPT5HBioGRID29395067 details
SPENDLX5HPRD10451362 details
SPENHDAC2HPRD11331609 details
SPENSOX9HPRD11331609 details
SPENRARAHPRD11331609 details
SPENMTA2HPRD11331609 details
SPENRBBP4HPRD11331609 details
SPENMSX2HPRD10451362 details
SPENBCL6IntAct16147992 details
SPENCDC5LMINT20467437 details
SPENBCLAF1BioGRID, IntAct26496610 details
SPENFERMT3BioGRID, IntAct26496610 details
SPENTCTE1IntAct26638075 details
SPENPIP4K2ABioGRID, IntAct28514442 details
SPENCAMKVBioGRID, IntAct28514442 details
SPENWRAP73BioGRID, IntAct26186194 28514442 details
SPENTRIML2BioGRID, IntAct28514442 details
SPENRRP1BIntAct20926688 details
SPENMKI67BioGRID, IntAct26949251 details
SPENHMGA1BioGRID, IntAct30021884 details
SPENRPL10ABioGRID, IntAct30021884 details
SPENMED23BioGRID, MINT25281560 details
SPENESR1BioGRID, IntAct31527615 details
SPENDAXXBioGRID, MINT24981860 details
SPENSOX2BioGRID, MINT23667531 28794006 details
SPENSIRT7BioGRID22586326 details
SPENNOTCH2BioGRID22939629 details
SPENBPGMBioGRID22939629 details
SPENTTNBioGRID22939629 details
SPENPRDX3BioGRID22939629 details
SPENPCBP3BioGRID22939629 details
SPENNUP54BioGRID22939629 details
SPENPIRBioGRID22939629 details
SPENSCYL2BioGRID22939629 details
SPENCUL7BioGRID24711643 details
SPENOBSL1BioGRID24711643 details
SPENEEDBioGRID24457600 details
SPENBMI1BioGRID24457600 details
SPENCCNCBioGRID26186194 28514442 details
SPENDYNLT1BioGRID26638075 details
SPENUSP37BioGRID26299517 details
SPENDPPA4BioGRID26687479 details
SPENEGFRBioGRID28065597 details
SPENHIF1ANBioGRID26972000 details
SPENPYHIN1BioGRID28077445 details
SPENIRF2BP2BioGRID26593974 details
SPENCHD4BioGRID28977666 details
SPENEZH2BioGRID27634302 details
SPENMYCBioGRID30415952 details
SPENXRCC6BioGRID30585729 details
SPENH4C1BioGRID30804502 details
SPENBIRC3BioGRID30948266 details
SPENRAD18BioGRID31076518 details
SPENZC3H18BioGRID29298432 details
SPENPRC1BioGRID31586073 details
SPENTRIM37BioGRID32908313 details
SPENASF1ABioGRID34079125 details
SPENCBX3BioGRID34079125 details
SPENDHX8BioGRID34079125 details
SPENH2BC8BioGRID34079125 details
SPENH3C1BioGRID34079125 details
SPENNUP50BioGRID34079125 details
SPENTERF2IPBioGRID34079125 details
SPENVIRMABioGRID29507755 details