Entity Details

Primary name WRN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14191
EntryNameWRN_HUMAN
FullNameWerner syndrome ATP-dependent helicase
TaxID9606
Evidenceevidence at protein level
Length1432
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesWRN

GO terms

Show/Hide Table
GOName
GO:0000287 magnesium ion binding
GO:0000400 four-way junction DNA binding
GO:0000403 Y-form DNA binding
GO:0000405 bubble DNA binding
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000731 DNA synthesis involved in DNA repair
GO:0000781 chromosome, telomeric region
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0004386 helicase activity
GO:0004527 exonuclease activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0007420 brain development
GO:0007568 aging
GO:0007569 cell aging
GO:0008408 3'-5' exonuclease activity
GO:0009267 cellular response to starvation
GO:0009378 four-way junction helicase activity
GO:0010225 response to UV-C
GO:0010259 multicellular organism aging
GO:0016607 nuclear speck
GO:0016887 ATP hydrolysis activity
GO:0030145 manganese ion binding
GO:0031297 replication fork processing
GO:0032201 telomere maintenance via semi-conservative replication
GO:0032405 MutLalpha complex binding
GO:0032508 DNA duplex unwinding
GO:0040009 regulation of growth rate
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0043138 3'-5' DNA helicase activity
GO:0044806 G-quadruplex DNA unwinding
GO:0044877 protein-containing complex binding
GO:0051345 positive regulation of hydrolase activity
GO:0051880 G-quadruplex DNA binding
GO:0061749 forked DNA-dependent helicase activity
GO:0061820 telomeric D-loop disassembly
GO:0061821 telomeric D-loop binding
GO:0061849 telomeric G-quadruplex DNA binding
GO:0070337 3'-flap-structured DNA binding
GO:0071480 cellular response to gamma radiation
GO:0090399 replicative senescence
GO:0090656 t-circle formation
GO:0098530 positive regulation of strand invasion
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902570 protein localization to nucleolus
GO:1905773 8-hydroxy-2'-deoxyguanosine DNA binding

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001650 Helicase, C-terminalDomainDomain
IPR002121 HRDC domainDomainDomain
IPR002562 3'-5' exonuclease domainDomainDomain
IPR004589 DNA helicase, ATP-dependent, RecQ typeFamilyFamily
IPR010997 HRDC-like superfamilyFamilyHomologous superfamily
IPR011545 DEAD/DEAH box helicase domainDomainDomain
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR018982 RQC domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR029491 Helicase Helix-turn-helix domainDomainDomain
IPR032284 ATP-dependent DNA helicase RecQ, zinc-binding domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

61 interactions

InteractorPartnerSourcesPublicationsLink
WRN_HUMANWRN_HUMANBioGRID, MINT10783163 details
WRN_HUMANXRCC5_HUMANBioGRID, HPRD, IntAct, MINT, Molecular Connections10783163 10880505 11328876 12177300 12937274 14734561 21679440 26496610 details
WRN_HUMANXRCC6_HUMANBioGRID, HPRD, IntAct, MINT10783163 10880505 11328876 12177300 14734561 26496610 28514442 30585729 details
WRN_HUMANRFA1_HUMANBioGRID, HPRD, IntAct, MINT10373438 15735006 15965237 24126761 24332808 26474068 27723720 30279242 details
WRN_HUMANPARP1_HUMANBioGRID, HPRD, IntAct, MINT14596914 14734561 details
WRN_HUMANH2AX_HUMANBioGRID, HPRD, MINT15733840 20802463 details
WRN_HUMANRAD52_HUMANBioGRID, HPRD, IntAct12750383 17118963 details
WRN_HUMANTERF2_HUMANBioGRID, HPRD, IntAct12181313 18212065 details
WRN_HUMANBLM_HUMANBioGRID, HPRD, IntAct11919194 details
WRN_HUMANFEN1_HUMANBioGRID, HPRD, IntAct11598021 12356323 14657243 14688284 16326861 details
WRN_HUMANP53_HUMANBioGRID, HPRD, IntAct11399766 11427532 12080066 15735006 details
WRN_HUMANSIR1_HUMANBioGRID, IntAct, UniProt18203716 19343720 details
WRN_HUMANRAD51_HUMANBioGRID, DIP17118963 18562274 details
WRN_HUMANBRCA1_HUMANBioGRID, UniProt16714450 24709898 29656893 details
WRN_HUMANMDC1_HUMANBioGRID14578343 details
WRN_HUMANATM_HUMANBioGRID, HPRD10608806 10839545 11252893 details
WRN_HUMANATR_HUMANBioGRID10608806 17118963 22159421 details
WRN_HUMANPRKDC_HUMANBioGRID, HPRD10608806 11889123 details
WRN_HUMANPCNA_HUMANBioGRID, HPRD10871373 12633936 12750383 20600238 details
WRN_HUMANWRIP1_HUMANBioGRID, HPRD11301316 details
WRN_HUMANCAF1A_HUMANBioGRID17173071 details
WRN_HUMANDPOLB_HUMANBioGRID17173071 details
WRN_HUMANDHX9_HUMANBioGRID15995249 17498979 details
WRN_HUMANATRX_HUMANBioGRID17118963 details
WRN_HUMANFSBP_HUMANBioGRID17118963 details
WRN_HUMANRA54B_HUMANBioGRID17118963 details
WRN_HUMANCDN2A_HUMANBioGRID15355988 details
WRN_HUMANARF_HUMANBioGRID, HPRD15355988 details
WRN_HUMANSUMO1_HUMANBioGRID16524884 details
WRN_HUMANSUMO2_HUMANBioGRID16524884 details
WRN_HUMANPOLK_HUMANBioGRID25294835 details
WRN_HUMANRAD9A_HUMANBioGRID22002307 details
WRN_HUMANRAD1_HUMANBioGRID22002307 details
WRN_HUMANBARD1_HUMANBioGRID16714450 details
WRN_HUMANMDM2_HUMANBioGRID30532073 details
WRN_HUMANMIB1_HUMANBioGRID32652764 details
WRN_HUMANKAP1_HUMANHPRD12067711 details
WRN_HUMANNALP2_HUMANMINT15733840 details
WRN_HUMANTERA_HUMANBioGRID, HPRD, IntAct12937274 15037256 details
WRN_HUMANUBC_HUMANMINT18588880 details
WRN_HUMANRFA2_HUMANBioGRID, MINT20802463 24126761 24332808 30279242 details
WRN_HUMANRFA3_HUMANBioGRID, IntAct, MINT24126761 24332808 27173435 30279242 unassigned1312 details
WRN_HUMANARL3_HUMANBioGRID, IntAct27173435 unassigned1312 details
WRN_HUMANDPOLL_HUMANBioGRID, IntAct27173435 unassigned1312 details
WRN_HUMANSP16H_HUMANBioGRID, IntAct27173435 unassigned1312 details
WRN_HUMANCBX5_HUMANDIP25931448 details
WRN_HUMANRPAC1_HUMANBioGRID, HPRD11971179 details
WRN_HUMANNBN_HUMANBioGRID15733840 20600238 details
WRN_HUMANCDC5L_HUMANBioGRID16223718 details
WRN_HUMANPML_HUMANBioGRID21639834 details
WRN_HUMANNKX21_HUMANBioGRID28192407 details
WRN_HUMANHERC2_HUMANBioGRID30279242 details
WRN_HUMANHDAC1_HUMANBioGRID27672210 details
WRN_HUMANHDAC2_HUMANBioGRID27672210 details
WRN_HUMANMOV10_HUMANBioGRID29395067 details
WRN_HUMANNXF1_HUMANBioGRID29395067 details
WRN_HUMANCPSF1_HUMANBioGRID29395067 details
WRN_HUMANSMG7_HUMANBioGRID29395067 details
WRN_HUMANILF3_HUMANBioGRID29395067 details
WRN_HUMANSHLD2_HUMANBioGRID30154076 details
WRN_HUMANDPOD2_HUMANHPRD11027336 details