Entity Details

Primary name PDK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15118
EntryNamePDK1_HUMAN
FullName[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length436
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesPDK1

GO terms

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GOName
GO:0004672 protein kinase activity
GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005967 mitochondrial pyruvate dehydrogenase complex
GO:0006006 glucose metabolic process
GO:0006468 protein phosphorylation
GO:0008283 cell population proliferation
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906 regulation of glucose metabolic process
GO:0097411 hypoxia-inducible factor-1alpha signaling pathway

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR003594 Histidine kinase/HSP90-like ATPaseDomainDomain
IPR005467 Histidine kinase domainDomainDomain
IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminalDomainDomain
IPR036784 Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily
IPR039028 PDK/BCKDK protein kinaseFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB07403 4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDEDrugbanksmall molecule
DB08809 Dichloroacetic acidDrugbanksmall molecule

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
PDK1_HUMANSGK3_HUMANMINT16888620 details
PDK1_HUMANEPAS1_HUMANMINT17024177 details
PDK1_HUMANKS6B1_HUMANBioGRID, HPRD, MINT11279232 11733037 17110931 details
PDK1_HUMANPKN2_HUMANBioGRID, MINT10753910 17110931 details
PDK1_HUMANODPA_HUMANBioGRID, HPRD, IntAct, MINT11485553 11486000 12676647 22195962 24486017 26186194 27505672 29568061 34079125 7782287 details
PDK1_HUMANXRCC6_HUMANBioGRID, MINT21900206 details
PDK1_HUMANPDK2_HUMANBioGRID, HPRD, IntAct12573248 26186194 26496610 28514442 29568061 details
PDK1_HUMANAKT1_HUMANBioGRID, IntAct27166089 27505672 details
PDK1_HUMANAKT2_HUMANIntAct27505672 details
PDK1_HUMANPDK1_HUMANBioGRID, DIP17683942 18003900 29568061 details
PDK1_HUMANODP2_HUMANBioGRID, HPRD, IntAct11978179 29568061 details
PDK1_HUMANA4_HUMANIntAct32814053 details
PDK1_HUMANSGK1_HUMANBioGRID17314099 details
PDK1_HUMANUBP4_HUMANBioGRID22347420 details
PDK1_HUMANKAT2B_HUMANBioGRID21775285 details
PDK1_HUMANLTOR5_HUMANBioGRID23241634 details
PDK1_HUMANPK3CA_HUMANBioGRID21041639 details
PDK1_HUMANITB3_HUMANBioGRID10896934 details
PDK1_HUMANFGFR1_HUMANBioGRID22195962 details
PDK1_HUMANGRSF1_HUMANBioGRID, IntAct29395067 29568061 32877691 details
PDK1_HUMANGNDS_HUMANBioGRID11889038 details
PDK1_HUMANRPTOR_HUMANBioGRID12150926 24516643 details
PDK1_HUMANPKN1_HUMANBioGRID10753910 details
PDK1_HUMANMTOR_HUMANBioGRID24516643 details
PDK1_HUMANACK1_HUMANBioGRID25257795 details
PDK1_HUMANMTG16_HUMANBioGRID25974097 details
PDK1_HUMANHIF1A_HUMANBioGRID25974097 details
PDK1_HUMANARNT_HUMANBioGRID25974097 details
PDK1_HUMANPTN6_HUMANBioGRID19591923 details
PDK1_HUMANBIEA_HUMANBioGRID27166089 details
PDK1_HUMAN1433T_HUMANHPRD19010391 details