Entity Details

Primary name PTPRK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15262
EntryNamePTPRK_HUMAN
FullNameReceptor-type tyrosine-protein phosphatase kappa
TaxID9606
Evidenceevidence at protein level
Length1439
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPTPRK

GO terms

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GOName
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0006470 protein dephosphorylation
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008013 beta-catenin binding
GO:0008285 negative regulation of cell population proliferation
GO:0009986 cell surface
GO:0010839 negative regulation of keratinocyte proliferation
GO:0016021 integral component of membrane
GO:0016477 cell migration
GO:0019901 protein kinase binding
GO:0030054 cell junction
GO:0030336 negative regulation of cell migration
GO:0031256 leading edge membrane
GO:0034394 protein localization to cell surface
GO:0034614 cellular response to reactive oxygen species
GO:0034644 cellular response to UV
GO:0043231 intracellular membrane-bounded organelle
GO:0045295 gamma-catenin binding
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048041 focal adhesion assembly

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR000998 MAM domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013098 Immunoglobulin I-setDomainDomain
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041201 PTPRJ, transmembrane domainDomainDomain

Diseases

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