Entity Details

Primary name SMAD6
Entity type gene
Source Source Link

Details

PrimaryID4091
RefseqGeneNG_012244
SymbolSMAD6
NameSMAD family member 6
Chromosome15
Location15q22.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-12
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSMAD6_HUMAN

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0001657 ureteric bud development
GO:0003148 outflow tract septum morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003183 mitral valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003281 ventricular septum development
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006955 immune response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007352 zygotic specification of dorsal/ventral axis
GO:0008285 negative regulation of cell population proliferation
GO:0009653 anatomical structure morphogenesis
GO:0010991 negative regulation of SMAD protein complex assembly
GO:0016604 nuclear body
GO:0030154 cell differentiation
GO:0030279 negative regulation of ossification
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031589 cell-substrate adhesion
GO:0031625 ubiquitin protein ligase binding
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0034616 response to laminar fluid shear stress
GO:0034713 type I transforming growth factor beta receptor binding
GO:0035904 aorta development
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043627 response to estrogen
GO:0045444 fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0046872 metal ion binding
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060976 coronary vasculature development
GO:0070410 co-SMAD binding
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
GO:0070698 type I activin receptor binding
GO:0071144 heteromeric SMAD protein complex
GO:0140416 transcription regulator inhibitor activity
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II

Diseases

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Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
SMAD6SMURF2BioGRID, HPRD, MINT15221015 15231748 15761153 24850914 details
SMAD6STAMBPBioGRID, HPRD, IntAct11483516 details
SMAD6PRKXUniProt16491121 details
SMAD6MAPK6BioGRID, MINT21900206 details
SMAD6RPS6KA5BioGRID, MINT21900206 details
SMAD6FKBP1Abhf-ucl16720724 details
SMAD6SMAD6bhf-ucl9436979 details
SMAD6SMAD1bhf-ucl, BioGRID, HPRD11483516 12857866 9256479 9436979 details
SMAD6CHRM5BioGRID, MINT28298427 details
SMAD6PIAS4BioGRID12815042 details
SMAD6HOXC8BioGRID, HPRD10722652 details
SMAD6SMAD7BioGRID, HPRD26555259 9256479 details
SMAD6SMURF1BioGRID, HPRD11278251 15221015 17676934 21897371 28847510 29950561 details
SMAD6TOB1HPRD12782279 details
SMAD6RUNX2HPRD, IntAct16299379 details
SMAD6UBE2OBioGRID, MINT23455153 details
SMAD6RNF165DIP23610558 details
SMAD6CTBP1BioGRID14645520 24850914 details
SMAD6RNF111BioGRID, HPRD14657019 details
SMAD6MAP3K7BioGRID, HPRD10748100 11737269 details
SMAD6TAB1BioGRID, HPRD11737269 details
SMAD6STRAPBioGRID, HPRD10757800 details
SMAD6YAP1BioGRID12118366 details
SMAD6SMAD2BioGRID9256479 details
SMAD6SMAD4BioGRID15817471 9256479 details
SMAD6NEDD4BioGRID15496141 details
SMAD6WWP1BioGRID15221015 15359284 24850914 details
SMAD6ZEB1BioGRID20514018 details
SMAD6TSC22D1BioGRID21791611 details
SMAD6SMAD5BioGRID12857866 details
SMAD6PELI1BioGRID16951688 details
SMAD6BMPR1BBioGRID, HPRD11483516 15761153 9436979 details
SMAD6TGFBR1BioGRID, HPRD20663871 9335505 9436979 details
SMAD6ACTR1BBioGRID9436979 details
SMAD6BAMBIBioGRID19758997 details
SMAD6BMPR2BioGRID20663871 details
SMAD6ACVR1BioGRID20663871 23455153 details
SMAD6BMPR1ABioGRID20663871 details
SMAD6ACVR1BBioGRID20663871 details
SMAD6ACVR2BBioGRID20663871 details
SMAD6MYD88BioGRID21897371 details
SMAD6USP11BioGRID24850914 details
SMAD6USP15BioGRID24850914 details
SMAD6BPIFA1BioGRID24850914 details
SMAD6LYZBioGRID24850914 details
SMAD6PIGRBioGRID24850914 details
SMAD6WWP2BioGRID24850914 details
SMAD6ITCHBioGRID24850914 details
SMAD6NEDD4LBioGRID24850914 details
SMAD6NASPBioGRID24850914 details
SMAD6KPNA2BioGRID24850914 details
SMAD6CTBP2BioGRID24850914 details
SMAD6PIAS3BioGRID29950561 details
SMAD6TNFAIP3BioGRID29720226 details
SMAD6CUL2BioGRID, IntAct21145461 details
SMAD6ELAVL1BioGRID19322201 details
SMAD6HNRNPH1BioGRID26760575 details