Entity Details

Primary name PF4
Entity type gene
Source Source Link

Details

PrimaryID5196
RefseqGeneNG_032897
SymbolPF4
Nameplatelet factor 4
Chromosome4
Location4q13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-04-24
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsPLF4_HUMAN

GO terms

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GOName
GO:0002576 platelet degranulation
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0008009 chemokine activity
GO:0008201 heparin binding
GO:0010628 positive regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0020005 symbiont-containing vacuole membrane
GO:0030168 platelet activation
GO:0030593 neutrophil chemotaxis
GO:0030595 leukocyte chemotaxis
GO:0031093 platelet alpha granule lumen
GO:0031640 killing of cells of other organism
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042127 regulation of cell population proliferation
GO:0042832 defense response to protozoan
GO:0045236 CXCR chemokine receptor binding
GO:0045347 negative regulation of MHC class II biosynthetic process
GO:0045651 positive regulation of macrophage differentiation
GO:0045652 regulation of megakaryocyte differentiation
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048248 CXCR3 chemokine receptor binding
GO:0051873 killing by host of symbiont cells
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0062023 collagen-containing extracellular matrix
GO:0070098 chemokine-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
PF4TNFAIP6IntAct27044744 details
PF4CCL5bhf-ucl, BioGRID, HPRD15459010 28381538 details
PF4CXCL17bhf-ucl, BioGRID28381538 details
PF4CXCL14bhf-ucl, BioGRID28381538 details
PF4CXCL12bhf-ucl, BioGRID10233851 28381538 details
PF4CXCL11bhf-ucl, BioGRID28381538 details
PF4CXCL10bhf-ucl, BioGRID28381538 details
PF4CXCL9bhf-ucl, BioGRID28381538 details
PF4CXCL8bhf-ucl, BioGRID, HPRD12586630 15531763 28381538 details
PF4CXCL6bhf-ucl, BioGRID28381538 details
PF4PF4bhf-ucl, BioGRID, HPRD28381538 7547867 7835432 8031770 details
PF4CXCL2bhf-ucl, BioGRID28381538 details
PF4XCL1bhf-ucl, BioGRID28381538 details
PF4CCL28bhf-ucl, BioGRID28381538 details
PF4CCL26bhf-ucl, BioGRID28381538 details
PF4CCL25bhf-ucl, BioGRID28381538 details
PF4CCL21bhf-ucl, BioGRID28381538 details
PF4CCL20bhf-ucl, BioGRID28381538 details
PF4CCL17bhf-ucl28381538 details
PF4CCL13bhf-ucl, BioGRID28381538 details
PF4CCL11bhf-ucl, BioGRID28381538 details
PF4CCL2bhf-ucl, BioGRID28381538 details
PF4XCL2bhf-ucl, BioGRID28381538 details
PF4CXCR3BioGRID, HPRD12782716 details
PF4THBDBioGRID, HPRD9395524 details
PF4PROCBioGRID, HPRD9395524 details
PF4LDLRBioGRID, HPRD11986215 details
PF4VCANBioGRID11083865 details
PF4APOHIntAct19805618 details
PF4SRGNHPRD8613703 details
PF4FGF2HPRD9558385 details
PF4SDC2HPRD7524669 details
PF4PLEKIntAct19722192 details