Entity Details

Primary name CP1B1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16678
EntryNameCP1B1_HUMAN
FullNameCytochrome P450 1B1
TaxID9606
Evidenceevidence at protein level
Length543
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesCYP1B1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0002930 trabecular meshwork development
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0006725 cellular aromatic compound metabolic process
GO:0006805 xenobiotic metabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0007155 cell adhesion
GO:0008202 steroid metabolic process
GO:0008210 estrogen metabolic process
GO:0008285 negative regulation of cell population proliferation
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009404 toxin metabolic process
GO:0009636 response to toxic substance
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0016125 sterol metabolic process
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019369 arachidonic acid metabolic process
GO:0019373 epoxygenase P450 pathway
GO:0020037 heme binding
GO:0030199 collagen fibril organization
GO:0030336 negative regulation of cell migration
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0042572 retinol metabolic process
GO:0042574 retinal metabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043542 endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0046466 membrane lipid catabolic process
GO:0048514 blood vessel morphogenesis
GO:0061304 retinal blood vessel morphogenesis
GO:0070301 cellular response to hydrogen peroxide
GO:0070330 aromatase activity
GO:0071407 cellular response to organic cyclic compound
GO:0071603 endothelial cell-cell adhesion
GO:0097267 omega-hydroxylase P450 pathway
GO:0101020 estrogen 16-alpha-hydroxylase activity
GO:0106256 hydroperoxy icosatetraenoate dehydratase activity
GO:2000377 regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane
Mitochondrion

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR032971 Cytochrome P450 1B1FamilyFamily
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00121 BiotinDrugbanksmall molecule
DB00201 CaffeineDrugbanksmall molecule
DB00277 TheophyllineDrugbanksmall molecule
DB00338 OmeprazoleDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00443 BetamethasoneDrugbanksmall molecule
DB00448 LansoprazoleDrugbanksmall molecule
DB00499 FlutamideDrugbanksmall molecule
DB00530 ErlotinibDrugbanksmall molecule
DB00613 AmodiaquineDrugbanksmall molecule
DB00624 TestosteroneDrugbanksmall molecule
DB00635 PrednisoneDrugbanksmall molecule
DB00655 EstroneDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00694 DaunorubicinDrugbanksmall molecule
DB00741 HydrocortisoneDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB00818 PropofolDrugbanksmall molecule
DB00959 MethylprednisoloneDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01026 KetoconazoleDrugbanksmall molecule
DB01065 MelatoninDrugbanksmall molecule
DB01087 PrimaquineDrugbanksmall molecule
DB01204 MitoxantroneDrugbanksmall molecule
DB01222 BudesonideDrugbanksmall molecule
DB01229 PaclitaxelDrugbanksmall molecule
DB01248 DocetaxelDrugbanksmall molecule
DB01254 DasatinibDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB02342 2-MethoxyestradiolDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB03467 NaringeninDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB06732 beta-NaphthoflavoneDrugbanksmall molecule
DB07776 FlavoneDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB11155 TriclocarbanDrugbanksmall molecule
DB12245 TriclabendazoleDrugbanksmall molecule
DB13946 Testosterone undecanoateDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14631 Prednisolone phosphateDrugbanksmall molecule