Entity Details

Primary name CP51A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16850
EntryNameCP51A_HUMAN
FullNameLanosterol 14-alpha demethylase
TaxID9606
Evidenceevidence at protein level
Length503
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCYP51A1

GO terms

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GOName
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006694 steroid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0007399 nervous system development
GO:0008398 sterol 14-demethylase activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016125 sterol metabolic process
GO:0016491 oxidoreductase activity
GO:0019216 regulation of lipid metabolic process
GO:0020037 heme binding
GO:0042177 negative regulation of protein catabolic process
GO:0050709 negative regulation of protein secretion
GO:1900222 negative regulation of amyloid-beta clearance

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002403 Cytochrome P450, E-class, group IVFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01007 TioconazoleDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01167 ItraconazoleDrugbanksmall molecule
DB05667 LevoketoconazoleDrugbanksmall molecule
DB07705 (S)-econazoleDrugbanksmall molecule

Interactions

3 interactions