Entity Details

Primary name TEK
Entity type gene
Source Source Link

Details

PrimaryID7010
RefseqGeneNG_011828
SymbolTEK
NameTEK receptor tyrosine kinase
Chromosome9
Location9p21.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-07-19
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTIE2_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0001935 endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001958 endochondral ossification
GO:0002040 sprouting angiogenesis
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005902 microvillus
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development
GO:0007507 heart development
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016525 negative regulation of angiogenesis
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019838 growth factor binding
GO:0032878 regulation of establishment or maintenance of cell polarity
GO:0033674 positive regulation of kinase activity
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034451 centriolar satellite
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043114 regulation of vascular permeability
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043627 response to estrogen
GO:0045121 membrane raft
GO:0045766 positive regulation of angiogenesis
GO:0046777 protein autophosphorylation
GO:0048014 Tie signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050900 leukocyte migration
GO:0051591 response to cAMP
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060216 definitive hemopoiesis
GO:0060347 heart trabecula formation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0072012 glomerulus vasculature development
GO:1902533 positive regulation of intracellular signal transduction
GO:2000251 positive regulation of actin cytoskeleton reorganization
GO:2000351 regulation of endothelial cell apoptotic process
GO:2000352 negative regulation of endothelial cell apoptotic process

Diseases

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Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
TEKPTPRCIntAct19167335 details
TEKPTPRKIntAct19167335 details
TEKPTPRGIntAct19167335 details
TEKPTPRBHPRD, IntAct10557082 19167335 details
TEKPTPRJIntAct19167335 details
TEKPTPROIntAct19167335 details
TEKPTPN12IntAct19167335 details
TEKANGPT2BioGRID, DIP, HPRD, IntAct12427764 15893672 16732286 20708158 25237190 9204896 9723709 details
TEKANGPT1BioGRID, HPRD, IntAct12427764 20708158 8980223 8980224 9204896 9723709 details
TEKANGPT4BioGRID, HPRD, IntAct10051567 20708158 details
TEKSHC1BioGRID, HPRD, MINT14665640 details
TEKIKBKGBioGRID, IntAct20098747 details
TEKSTYXBioGRID, MINT28065597 details
TEKDUSP18BioGRID, MINT28065597 details
TEKPTPRRBioGRID, MINT28065597 details
TEKILKAPBioGRID, MINT28065597 details
TEKPTPN11BioGRID, HPRD, MINT10521483 28065597 details
TEKDOK2BioGRID, HPRD11689432 9764820 details
TEKTNIP2BioGRID, HPRD12609966 details
TEKAPPBioGRID21832049 details
TEKTEKBioGRID, HPRD10521483 11080633 26285778 9632797 details
TEKCAV1BioGRID28760776 details
TEKSOCS1BioGRID, HPRD10022833 29991678 details
TEKPIK3R1HPRD10521483 details
TEKGRB2HPRD10521483 7478529 details
TEKGRB7HPRD10521483 details
TEKGRB14HPRD10521483 details
TEKCYP1B1IntAct28620713 details
TEKTIE1BioGRID, HPRD10995770 details
TEKCBLBioGRID19689429 details
TEKPTK2BioGRID25792870 details
TEKAKT1BioGRID25792870 details
TEKERBB2BioGRID30898150 details
TEKANGPTL1HPRD10051567 details
TEKSTAT5AHPRD14726409 details
TEKSTAT5BHPRD14726409 details
TEKDOK4HPRD11470823 details
TEKMAPK3BioGRID, IntAct23602568 details
TEKPKMIntAct24606918 details