Entity Details

Primary name THBS1
Entity type gene
Source Source Link

Details

PrimaryID7057
RefseqGene
SymbolTHBS1
Namethrombospondin 1
Chromosome15
Location15q14
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-18
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsTSP1_HUMAN

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001666 response to hypoxia
GO:0001786 phosphatidylserine binding
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001953 negative regulation of cell-matrix adhesion
GO:0001968 fibronectin binding
GO:0002040 sprouting angiogenesis
GO:0002544 chronic inflammatory response
GO:0002576 platelet degranulation
GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002605 negative regulation of dendritic cell antigen processing and presentation
GO:0005178 integrin binding
GO:0005201 extracellular matrix structural constituent
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006986 response to unfolded protein
GO:0007155 cell adhesion
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0009612 response to mechanical stimulus
GO:0009749 response to glucose
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010596 negative regulation of endothelial cell migration
GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane
GO:0010751 negative regulation of nitric oxide mediated signal transduction
GO:0010754 negative regulation of cGMP-mediated signaling
GO:0010757 negative regulation of plasminogen activation
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010763 positive regulation of fibroblast migration
GO:0016477 cell migration
GO:0016525 negative regulation of angiogenesis
GO:0016529 sarcoplasmic reticulum
GO:0017134 fibroblast growth factor binding
GO:0018149 peptide cross-linking
GO:0030141 secretory granule
GO:0030169 low-density lipoprotein particle binding
GO:0030194 positive regulation of blood coagulation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031012 extracellular matrix
GO:0031091 platelet alpha granule
GO:0031093 platelet alpha granule lumen
GO:0032026 response to magnesium ion
GO:0032570 response to progesterone
GO:0032695 negative regulation of interleukin-12 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032914 positive regulation of transforming growth factor beta1 production
GO:0033574 response to testosterone
GO:0034605 cellular response to heat
GO:0034976 response to endoplasmic reticulum stress
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042327 positive regulation of phosphorylation
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043032 positive regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043236 laminin binding
GO:0043394 proteoglycan binding
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043652 engulfment of apoptotic cell
GO:0045652 regulation of megakaryocyte differentiation
GO:0045727 positive regulation of translation
GO:0045766 positive regulation of angiogenesis
GO:0048266 behavioral response to pain
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050431 transforming growth factor beta binding
GO:0050921 positive regulation of chemotaxis
GO:0051592 response to calcium ion
GO:0051895 negative regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051918 negative regulation of fibrinolysis
GO:0062023 collagen-containing extracellular matrix
GO:0070051 fibrinogen binding
GO:0070052 collagen V binding
GO:0070062 extracellular exosome
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1903671 negative regulation of sprouting angiogenesis
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001027 negative regulation of endothelial cell chemotaxis
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Diseases

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Interactions

78 interactions

InteractorPartnerSourcesPublicationsLink
THBS1TGM2IntAct19542224 details
THBS1FN1HPRD, IntAct11773026 18042364 19542224 details
THBS1TGFB1BioGRID, HPRD, UniProt1550960 15864306 details
THBS1PCOLCEmatrixdb24117177 details
THBS1LRP1BioGRID, HPRD14991768 7775583 9045712 details
THBS1IGFBP5BioGRID, HPRD10698186 details
THBS1PLGBioGRID, HPRD2522013 6438154 details
THBS1COL3A1BioGRID, HPRD3571333 details
THBS1COL2A1BioGRID, HPRD3571333 details
THBS1COL1A1BioGRID, HPRD3571333 details
THBS1COL4A1BioGRID3571333 details
THBS1COL5A1BioGRID, HPRD3571333 6693501 9840442 details
THBS1CALCRBioGRID12147682 details
THBS1TFPIBioGRID, HPRD10922378 details
THBS1ITGB3BioGRID, HPRD14963009 2478219 details
THBS1F2BioGRID, HPRD2435757 details
THBS1LRP2BioGRID7775583 details
THBS1PDGFBBioGRID, HPRD9334164 details
THBS1SCARB2BioGRID, HPRD9478926 details
THBS1ELANEBioGRID, HPRD8463250 details
THBS1FGABioGRID, HPRD9867861 details
THBS1COL7A1BioGRID, HPRD9840442 details
THBS1MMP2BioGRID, HPRD10900205 details
THBS1MMP9BioGRID, HPRD10900205 11606713 details
THBS1FGF2BioGRID17996481 details
THBS1HSP90AA1BioGRID31273033 details
THBS1JAG1HPRD15258909 details
THBS1LAMB3HPRD9840442 details
THBS1TNFAIP6HPRD, IntAct16006654 18042364 details
THBS1VEGFADIP19805200 details
THBS1HTRA1IntAct29572155 details
THBS1PSMD4BioGRID15095410 details
THBS1ITGAVBioGRID14963009 details
THBS1ITGB1BioGRID14963009 details
THBS1CD36HPRD10487979 10772961 details
THBS1SPARCHPRD2745554 details
THBS1KNG1HPRD9459346 details
THBS1CD47HPRD10397731 8550562 9169439 details
THBS1LRP5HPRD7775583 details
THBS1CORO1AHPRD10749676 details
THBS1CALRHPRD12147682 details
THBS1CTSGHPRD8408036 details
THBS1CFHHPRD15634279 details
THBS1TNFRSF11BHPRD15799029 details
THBS1DCNHPRD1550960 9328841 details
THBS1DHFRHPRD10749676 details
THBS1HRGHPRD6438154 details
THBS1PLEKIntAct19722192 details
THBS1IQCB1BioGRID, IntAct21565611 details
THBS1DDX31BioGRID, IntAct28514442 details
THBS1THBS3BioGRID, IntAct26186194 28514442 details
THBS1FCGRTBioGRID, IntAct28514442 details
THBS1THBS2BioGRID, IntAct28514442 details
THBS1H3C1BioGRID, IntAct29568061 details
THBS1H3C4IntAct29568061 details
THBS1H3C3IntAct29568061 details
THBS1H3C6IntAct29568061 details
THBS1H3C11IntAct29568061 details
THBS1H3C8IntAct29568061 details
THBS1H3C12IntAct29568061 details
THBS1H3C10IntAct29568061 details
THBS1H3C2IntAct29568061 details
THBS1H3C7IntAct29568061 details
THBS1TUBA1ABioGRID, IntAct29568061 details
THBS1NEK4BioGRID, MINT25798074 details
THBS1SOX2BioGRID, MINT23667531 details
THBS1DISC1BioGRID, MINT29961565 details
THBS1YAP1BioGRID25796446 details
THBS1ESR2BioGRID29509190 details
THBS1CGASBioGRID30471916 details
THBS1CYLDBioGRID31067453 details
THBS1LRRC31BioGRID33005030 details
THBS1NR3C1BioGRID31182584 details
THBS1INSIG1BioGRID32322062 details
THBS1INSIG2BioGRID32322062 details
THBS1ELAVL1BioGRID19322201 details
THBS1VIRMABioGRID29507755 details
THBS1MTDHBioGRID22199357 details