Entity Details

Primary name CDKAL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ5VV42
EntryNameCDKAL_HUMAN
FullNameThreonylcarbamoyladenosine tRNA methylthiotransferase
TaxID9606
Evidenceevidence at protein level
Length579
SequenceStatuscomplete
DateCreated2007-09-11
DateModified2021-06-02

Ontological Relatives

GenesCDKAL1

GO terms

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GOName
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005791 rough endoplasmic reticulum
GO:0006400 tRNA modification
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0035598 N6-threonylcarbomyladenosine methylthiotransferase activity
GO:0035600 tRNA methylthiolation
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0061712 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase
GO:1990145 maintenance of translational fidelity

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR002792 TRAM domainDomainDomain
IPR005839 MethylthiotransferaseFamilyFamily
IPR006466 MiaB-like tRNA modifying enzyme, archaeal-typeFamilyFamily
IPR006638 Elp3/MiaB/NifBDomainDomain
IPR007197 Radical SAMDomainDomain
IPR013848 Methylthiotransferase, N-terminalDomainDomain
IPR020612 Methylthiotransferase, conserved siteSiteConserved site
IPR023404 Radical SAM, alpha/beta horseshoeFamilyHomologous superfamily
IPR038135 Methylthiotransferase, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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