Entity Details

Primary name DAB2P_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ5VWQ8
EntryNameDAB2P_HUMAN
FullNameDisabled homolog 2-interacting protein
TaxID9606
Evidenceevidence at protein level
Length1189
SequenceStatuscomplete
DateCreated2006-10-17
DateModified2021-06-02

Ontological Relatives

GenesDAB2IP

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000165 MAPK cascade
GO:0000185 obsolete activation of MAPKKK activity
GO:0001525 angiogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0005096 GTPase activator activity
GO:0005123 death receptor binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0007049 cell cycle
GO:0007252 I-kappaB phosphorylation
GO:0007257 obsolete activation of JUN kinase activity
GO:0008285 negative regulation of cell population proliferation
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0010596 negative regulation of endothelial cell migration
GO:0010633 negative regulation of epithelial cell migration
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010976 positive regulation of neuron projection development
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016525 negative regulation of angiogenesis
GO:0017124 SH3 domain binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0021814 cell motility involved in cerebral cortex radial glia guided migration
GO:0021819 layer formation in cerebral cortex
GO:0030139 endocytic vesicle
GO:0030424 axon
GO:0030425 dendrite
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0032809 neuronal cell body membrane
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0034260 negative regulation of GTPase activity
GO:0034620 cellular response to unfolded protein
GO:0035148 tube formation
GO:0035591 signaling adaptor activity
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway
GO:0038026 reelin-mediated signaling pathway
GO:0040008 regulation of growth
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0043254 regulation of protein-containing complex assembly
GO:0043407 negative regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043507 positive regulation of JUN kinase activity
GO:0043547 positive regulation of GTPase activity
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity
GO:0044257 cellular protein catabolic process
GO:0044300 cerebellar mossy fiber
GO:0044301 climbing fiber
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045296 cadherin binding
GO:0045732 positive regulation of protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048147 negative regulation of fibroblast proliferation
GO:0048812 neuron projection morphogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051721 protein phosphatase 2A binding
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0070317 negative regulation of G0 to G1 transition
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071889 14-3-3 protein binding
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072577 endothelial cell apoptotic process
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090129 positive regulation of synapse maturation
GO:1900006 positive regulation of dendrite development
GO:1900744 regulation of p38MAPK cascade
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1903363 negative regulation of cellular protein catabolic process
GO:1903896 positive regulation of IRE1-mediated unfolded protein response
GO:1990032 parallel fiber
GO:1990597 AIP1-IRE1 complex
GO:2001224 positive regulation of neuron migration
GO:2001235 positive regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR001936 Ras GTPase-activating domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR021887 Domain of unknown function DUF3498DomainDomain
IPR023152 Ras GTPase-activating protein, conserved siteSiteConserved site
IPR030403 Disabled homologue 2-interacting proteinFamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR039360 Ras GTPase-activating proteinFamilyFamily

Diseases

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