Entity Details

Primary name CARL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ5VZK9
EntryNameCARL1_HUMAN
FullNameF-actin-uncapping protein LRRC16A
TaxID9606
Evidenceevidence at protein level
Length1371
SequenceStatuscomplete
DateCreated2008-03-18
DateModified2021-06-02

Ontological Relatives

GenesCARMIL1

GO terms

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GOName
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007015 actin filament organization
GO:0007596 blood coagulation
GO:0016477 cell migration
GO:0016607 nuclear speck
GO:0030027 lamellipodium
GO:0030032 lamellipodium assembly
GO:0030335 positive regulation of cell migration
GO:0030838 positive regulation of actin filament polymerization
GO:0031252 cell leading edge
GO:0031529 ruffle organization
GO:0031941 filamentous actin
GO:0044351 macropinocytosis
GO:0044354 macropinosome
GO:0044877 protein-containing complex binding
GO:0046415 urate metabolic process
GO:0051496 positive regulation of stress fiber assembly
GO:0051638 barbed-end actin filament uncapping
GO:0051639 actin filament network formation
GO:0070062 extracellular exosome
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1902745 positive regulation of lamellipodium organization
GO:2000813 negative regulation of barbed-end actin filament capping

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001611 Leucine-rich repeatRepeatRepeat
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR029764 Leucine-rich repeat-containing protein 16AFamilyFamily
IPR031943 CARMIL, C-terminal domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR041245 CARMIL, pleckstrin homology domainDomainDomain

Diseases

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Interactions

3 interactions