Entity Details

Primary name CTRO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14578
EntryNameCTRO_HUMAN
FullNameCitron Rho-interacting kinase
TaxID9606
Evidenceevidence at protein level
Length2027
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesCIT

GO terms

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GOName
GO:0000278 mitotic cell cycle
GO:0000281 mitotic cytokinesis
GO:0001223 transcription coactivator binding
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0017124 SH3 domain binding
GO:0018107 peptidyl-threonine phosphorylation
GO:0019901 protein kinase binding
GO:0030165 PDZ domain binding
GO:0030291 protein serine/threonine kinase inhibitor activity
GO:0031032 actomyosin structure organization
GO:0032467 positive regulation of cytokinesis
GO:0035331 negative regulation of hippo signaling
GO:0035556 intracellular signal transduction
GO:0046872 metal ion binding
GO:0048699 generation of neurons
GO:0051402 neuron apoptotic process
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR001180 Citron homology (CNH) domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR017405 Citron Rho-interacting kinaseFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR037708 Citron Rho-interacting kinase, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule