Entity Details

Primary name NEIL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96FI4
EntryNameNEIL1_HUMAN
FullNameEndonuclease 8-like 1
TaxID9606
Evidenceevidence at protein level
Length390
SequenceStatuscomplete
DateCreated2004-12-07
DateModified2021-06-02

Ontological Relatives

GenesNEIL1

GO terms

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GOName
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006979 response to oxidative stress
GO:0008022 protein C-terminus binding
GO:0008270 zinc ion binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0019104 DNA N-glycosylase activity
GO:0032074 negative regulation of nuclease activity
GO:0045008 depyrimidination
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR010979 Ribosomal protein S13-like, H2THFamilyHomologous superfamily
IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domainDomainDomain
IPR015371 Endonuclease VIII-like 1, DNA bindingDomainDomain
IPR015886 DNA glycosylase/AP lyase, H2TH DNA-bindingDomainDomain
IPR035937 MutM-like, N-terminalFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01592 IronDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB14488 Ferrous gluconateDrugbanksmall molecule
DB14489 Ferrous succinateDrugbanksmall molecule
DB14490 Ferrous ascorbateDrugbanksmall molecule
DB14491 Ferrous fumarateDrugbanksmall molecule
DB14501 Ferrous glycine sulfateDrugbanksmall molecule