Entity Details

Primary name HCD2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99714
EntryNameHCD2_HUMAN
FullName3-hydroxyacyl-CoA dehydrogenase type-2
TaxID9606
Evidenceevidence at protein level
Length261
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesHSD17B10

GO terms

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GOName
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005886 plasma membrane
GO:0006550 isoleucine catabolic process
GO:0006629 lipid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006699 bile acid biosynthetic process
GO:0007005 mitochondrion organization
GO:0008207 C21-steroid hormone metabolic process
GO:0008209 androgen metabolic process
GO:0008210 estrogen metabolic process
GO:0008709 cholate 7-alpha-dehydrogenase activity
GO:0009083 branched-chain amino acid catabolic process
GO:0030283 testosterone dehydrogenase [NAD(P)] activity
GO:0030678 mitochondrial ribonuclease P complex
GO:0042645 mitochondrial nucleoid
GO:0044594 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
GO:0047015 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
GO:0047035 testosterone dehydrogenase (NAD+) activity
GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase activity
GO:0051289 protein homotetramerization
GO:0062173 brexanolone metabolic process
GO:0070901 mitochondrial tRNA methylation
GO:0097745 mitochondrial tRNA 5'-end processing
GO:0106281 chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
GO:0106282 isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
GO:0106283 ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
GO:1990180 mitochondrial tRNA 3'-end processing

Subcellular Location

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Subcellular Location
Mitochondrion
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR002347 Short-chain dehydrogenase/reductase SDRFamilyFamily
IPR020904 Short-chain dehydrogenase/reductase, conserved siteSiteConserved site
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
300438 OMIMHDS10 mitochondrial disease (HSD10MD)An X-linked multisystemic disorder with highly variable severity. Age at onset ranges from the neonatal period to early childhood. Features include progressive neurodegeneration, psychomotor retardation, loss of mental and motor skills, seizures, cardiomyopathy, and visual and hearing impairment. Some patients manifest lactic acidosis and metabolic acidosis. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB02820 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone AdductDrugbanksmall molecule
DB09568 Omega-3-carboxylic acidsDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
HCD2_HUMANA4_HUMANBioGRID, HPRD, IntAct10371197 15087549 32814053 9338779 details
HCD2_HUMANTM10C_HUMANBioGRID, IntAct, UniProt18984158 28514442 29880640 details
HCD2_HUMANCHD3_HUMANBioGRID, MINT21900206 details
HCD2_HUMANFAF1_HUMANBioGRID, MINT21900206 details
HCD2_HUMANUB2D1_HUMANBioGRID, MINT21900206 details
HCD2_HUMANHCD2_HUMANDIP15342248 details
HCD2_HUMANPCNA_HUMANUniProt26030842 details
HCD2_HUMANHTRA2_HUMANBioGRID17266347 details
HCD2_HUMANALDOA_HUMANBioGRID22496890 26344197 details
HCD2_HUMANTOM40_HUMANBioGRID25591737 26344197 details
HCD2_HUMANPRKN_HUMANBioGRID25591737 details
HCD2_HUMANTOM20_HUMANBioGRID25591737 details
HCD2_HUMANPINK1_HUMANBioGRID25591737 31300519 details
HCD2_HUMANTOM22_HUMANBioGRID25591737 details
HCD2_HUMANODO1_HUMANBioGRID22496890 details
HCD2_HUMANAL3B1_HUMANBioGRID22496890 details
HCD2_HUMANATPA_HUMANBioGRID22496890 details
HCD2_HUMANCPSM_HUMANBioGRID22496890 details
HCD2_HUMANCISY_HUMANBioGRID22496890 32877691 34079125 details
HCD2_HUMANETFD_HUMANBioGRID22496890 details
HCD2_HUMANDHE3_HUMANBioGRID22496890 details
HCD2_HUMANHMGCL_HUMANBioGRID22496890 details
HCD2_HUMANHMCS2_HUMANBioGRID22496890 details
HCD2_HUMANODPA_HUMANBioGRID22496890 34079125 details
HCD2_HUMANODPB_HUMANBioGRID22496890 details
HCD2_HUMANODPX_HUMANBioGRID22496890 details
HCD2_HUMANECHA_HUMANBioGRID22496890 details
HCD2_HUMANECHB_HUMANBioGRID22496890 details
HCD2_HUMANGLNA_HUMANBioGRID22496890 details
HCD2_HUMANMDHC_HUMANBioGRID22496890 details
HCD2_HUMANPYGL_HUMANBioGRID22496890 details
HCD2_HUMANCIKS_HUMANBioGRID22496890 details
HCD2_HUMANTRAF5_HUMANBioGRID22496890 details
HCD2_HUMANTRAF6_HUMANBioGRID22496890 details
HCD2_HUMANPTEN_HUMANBioGRID31685992 details
HCD2_HUMANCDC42_HUMANBioGRID31478661 details
HCD2_HUMANHDAC5_HUMANBioGRID21081666 details
HCD2_HUMANITA4_HUMANBioGRID22623428 details
HCD2_HUMANGRSF1_HUMANBioGRID23473034 29395067 32877691 details
HCD2_HUMANATG5_HUMANBioGRID33024031 details