Entity Details

Primary name WNK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H4A3
EntryNameWNK1_HUMAN
FullNameSerine/threonine-protein kinase WNK1
TaxID9606
Evidenceevidence at protein level
Length2382
SequenceStatuscomplete
DateCreated2004-02-02
DateModified2021-06-02

Ontological Relatives

GenesWNK1

GO terms

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GOName
GO:0002028 regulation of sodium ion transport
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004860 protein kinase inhibitor activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006811 ion transport
GO:0007165 signal transduction
GO:0010766 negative regulation of sodium ion transport
GO:0010820 positive regulation of T cell chemotaxis
GO:0010923 negative regulation of phosphatase activity
GO:0016020 membrane
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019869 chloride channel inhibitor activity
GO:0019870 potassium channel inhibitor activity
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0030295 protein kinase activator activity
GO:0033633 negative regulation of cell-cell adhesion mediated by integrin
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0034260 negative regulation of GTPase activity
GO:0035556 intracellular signal transduction
GO:0038116 chemokine (C-C motif) ligand 21 signaling pathway
GO:0048666 neuron development
GO:0050794 regulation of cellular process
GO:0050801 ion homeostasis
GO:0050852 T cell receptor signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097022 lymphocyte migration into lymph node
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903288 positive regulation of potassium ion import across plasma membrane
GO:1904062 regulation of cation transmembrane transport
GO:1990869 cellular response to chemokine
GO:2000651 positive regulation of sodium ion transmembrane transporter activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domainDomainDomain

Diseases

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Disease IDSourceNameDescription
201300 OMIMNeuropathy, hereditary sensory and autonomic, 2A (HSAN2A)A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN2A is an autosomal recessive disorder characterized by impairment of pain, temperature and touch sensation, onset of symptoms in infancy or early childhood, occurrence of distal extremity pathologies (paronychia, whitlows, ulcers, and Charcot joints), frequent amputations, sensory loss that affects all modalities of sensation (lower and upper limbs and perhaps the trunk as well), absence or diminution of tendon reflexes (usually in all limbs), minimal autonomic dysfunction, absence of sensory nerve action potentials, and virtual absence of myelinated fibers with decreased numbers of unmyelinated fibers in sural nerves. The disease is caused by variants affecting the gene represented in this entry.
614492 OMIMPseudohypoaldosteronism 2C (PHA2C)An autosomal dominant disorder characterized by severe hypertension, hyperkalemia, hyperchloremia, mild hyperchloremic metabolic acidosis in some cases, and correction of physiologic abnormalities by thiazide diuretics. The disease is caused by variants affecting the gene represented in this entry.

Interactions

75 interactions

InteractorPartnerSourcesPublicationsLink
WNK1_HUMANATX1_HUMANBioGRID, HPRD, IntAct16713569 details
WNK1_HUMANGLIS2_HUMANBioGRID, MINT17289029 details
WNK1_HUMANOXSR1_HUMANDIP, MINT16832045 17721439 details
WNK1_HUMANMP2K1_HUMANBioGRID, IntAct20936779 details
WNK1_HUMAN1433E_HUMANBioGRID, IntAct20936779 details
WNK1_HUMAN1433G_HUMANBioGRID, HPRD, IntAct15324660 20936779 28514442 details
WNK1_HUMANCSN5_HUMANBioGRID, IntAct20936779 details
WNK1_HUMANNED4L_HUMANBioGRID, IntAct20525693 20936779 26241057 details
WNK1_HUMANWNK1_HUMANBioGRID, IntAct20936779 details
WNK1_HUMANWNK2_HUMANBioGRID, IntAct20936779 details
WNK1_HUMAN1433Z_HUMANBioGRID, IntAct20936779 details
WNK1_HUMANARAF_HUMANBioGRID, IntAct21988832 details
WNK1_HUMANPFKAP_HUMANBioGRID, IntAct21988832 details
WNK1_HUMANPVR_HUMANBioGRID, IntAct21988832 details
WNK1_HUMANPP1A_HUMANUniProt19389623 details
WNK1_HUMANTULP3_HUMANBioGRID, IntAct23414517 details
WNK1_HUMANE2F3_HUMANBioGRID12748276 details
WNK1_HUMANCLH1_HUMANBioGRID20936779 26496610 details
WNK1_HUMANFLNC_HUMANBioGRID20936779 details
WNK1_HUMANATP8_HUMANBioGRID20936779 details
WNK1_HUMANKAP0_HUMANBioGRID20936779 details
WNK1_HUMANKAP1_HUMANBioGRID20936779 details
WNK1_HUMANSL9A1_HUMANBioGRID20936779 details
WNK1_HUMANZYX_HUMANBioGRID20936779 34079125 details
WNK1_HUMANCSDE1_HUMANBioGRID20936779 details
WNK1_HUMANT22D1_HUMANBioGRID20936779 details
WNK1_HUMANBAG3_HUMANBioGRID20936779 details
WNK1_HUMANRANB9_HUMANBioGRID20936779 details
WNK1_HUMANTNR6A_HUMANBioGRID20936779 details
WNK1_HUMANZN106_HUMANBioGRID20936779 details
WNK1_HUMANKLHL3_HUMANBioGRID23387299 23576762 23838290 26286618 29904119 details
WNK1_HUMANKLHL2_HUMANBioGRID23838290 24641320 28514442 details
WNK1_HUMANRENT2_HUMANBioGRID15231747 details
WNK1_HUMANADRB2_HUMANBioGRID24561123 details
WNK1_HUMANFHL3_HUMANBioGRID25416956 32296183 details
WNK1_HUMANUBC9_HUMANBioGRID15561718 details
WNK1_HUMANMAOM_HUMANIntAct17353931 details
WNK1_HUMANBAD_HUMANIntAct20936779 details
WNK1_HUMANZN839_HUMANIntAct20936779 details
WNK1_HUMANFA13B_HUMANIntAct20936779 details
WNK1_HUMANRIPR2_HUMANIntAct20936779 details
WNK1_HUMANCENPJ_HUMANIntAct20936779 details
WNK1_HUMANCGNL1_HUMANIntAct20936779 details
WNK1_HUMANCAF1A_HUMANIntAct20936779 details
WNK1_HUMANE41L2_HUMANIntAct20936779 details
WNK1_HUMANEIF3A_HUMANIntAct20936779 details
WNK1_HUMANFHOD1_HUMANIntAct20936779 details
WNK1_HUMANRMD3_HUMANIntAct20936779 details
WNK1_HUMANHDAC9_HUMANIntAct20936779 details
WNK1_HUMANZEP2_HUMANIntAct20936779 details
WNK1_HUMANK0232_HUMANIntAct20936779 details
WNK1_HUMANLCP2_HUMANIntAct20936779 details
WNK1_HUMANIRAG2_HUMANIntAct20936779 details
WNK1_HUMANMADD_HUMANIntAct20936779 details
WNK1_HUMANMPP9_HUMANIntAct20936779 details
WNK1_HUMANMYH9_HUMANIntAct20936779 details
WNK1_HUMANMSL2_HUMANIntAct20936779 details
WNK1_HUMANITPI2_HUMANIntAct20936779 details
WNK1_HUMANSYNPO_HUMANIntAct20936779 details
WNK1_HUMANSYNP2_HUMANIntAct20936779 details
WNK1_HUMANTNAP3_HUMANIntAct20936779 details
WNK1_HUMANTENS1_HUMANIntAct20936779 details
WNK1_HUMANWWTR1_HUMANIntAct20936779 details
WNK1_HUMANRPGP2_HUMANIntAct20936779 details
WNK1_HUMANSIMC1_HUMANIntAct20936779 details
WNK1_HUMANFA53C_HUMANIntAct20936779 details
WNK1_HUMANRASL3_HUMANIntAct20936779 details
WNK1_HUMANPLEC_HUMANBioGRID, IntAct27173435 30021884 unassigned1312 details
WNK1_HUMANAAK1_HUMANBioGRID, IntAct27173435 unassigned1312 details
WNK1_HUMANSGK1_HUMANBioGRID16006511 20525693 details
WNK1_HUMAN1433T_HUMANBioGRID23444366 details
WNK1_HUMANSYT2_HUMANHPRD15350218 details
WNK1_HUMANAKT1_HUMANHPRD14611643 details
WNK1_HUMANM3K3_HUMANHPRD14681216 details
WNK1_HUMANM3K2_HUMANHPRD14681216 details